NOS1 and ADRA1B

Number of citations of the paper that reports this interaction (PMID 12184796)
3

Data Source:
HPRD (in vivo)

		NOS1	ADRA1B
Gene Name		nitric oxide synthase 1 (neuronal)	adrenoceptor alpha 1B
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Photoreceptor Inner Segment Cytoplasm Mitochondrion Cytosol Cytoskeleton Sarcoplasmic Reticulum Sarcolemma Dendritic Spine Protein Complex Membrane Raft Synapse Perinuclear Region Of Cytoplasm Ryanodine Receptor Complex	Nucleus Plasma Membrane Integral Component Of Plasma Membrane Nuclear Membrane
	Molecular Function	NADPH-hemoprotein Reductase Activity Nitric-oxide Synthase Activity Iron Ion Binding Protein Binding Calmodulin Binding FMN Binding Oxidoreductase Activity Sodium Channel Regulator Activity Heme Binding Tetrahydrobiopterin Binding Arginine Binding Ion Channel Binding Cadmium Ion Binding Flavin Adenine Dinucleotide Binding NADP Binding Scaffold Protein Binding	Alpha1-adrenergic Receptor Activity Protein Heterodimerization Activity
	Biological Process	Response To Hypoxia Regulation Of Sodium Ion Transport Arginine Catabolic Process Nitric Oxide Biosynthetic Process Striated Muscle Contraction Nitric Oxide Mediated Signal Transduction Myoblast Fusion Blood Coagulation Response To Heat Negative Regulation Of Calcium Ion Transport Into Cytosol Peptidyl-cysteine S-nitrosylation Positive Regulation Of Guanylate Cyclase Activity Multicellular Organismal Response To Stress Positive Regulation Of Histone Acetylation Neurotransmitter Biosynthetic Process Exogenous Drug Catabolic Process Negative Regulation Of Potassium Ion Transport Negative Regulation Of Blood Pressure Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Vasodilation Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Hydrolase Activity Negative Regulation Of Serotonin Uptake Interaction With Host Negative Regulation Of Calcium Ion Transport Oxidation-reduction Process Regulation Of Cardiac Muscle Contraction Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Cellular Response To Growth Factor Stimulus Phagosome Maturation Positive Regulation Of The Force Of Heart Contraction Negative Regulation Of Adrenergic Receptor Signaling Pathway Involved In Heart Process Positive Regulation Of Adrenergic Receptor Signaling Pathway Involved In Heart Process Positive Regulation Of Sodium Ion Transmembrane Transport Regulation Of Generation Of L-type Calcium Current	Blood Vessel Remodeling Response To Amphetamine Vasoconstriction Of Artery Involved In Baroreceptor Response To Lowering Of Systemic Arterial Blood Pressure Positive Regulation Of Heart Rate By Epinephrine-norepinephrine Positive Regulation Of The Force Of Heart Contraction By Epinephrine-norepinephrine G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Cell-cell Signaling Multicellular Organismal Development Adult Heart Development Locomotory Behavior Cell Proliferation Visual Learning Cell Growth Regulation Of Vasoconstriction Organ Growth Intracellular Signal Transduction Glucose Homeostasis Response To Morphine Positive Regulation Of MAPK Cascade Negative Regulation Of Glycogen Catabolic Process Positive Regulation Of Glycogen Catabolic Process Behavioral Response To Cocaine Regulation Of Cardiac Muscle Contraction Adrenergic Receptor Signaling Pathway
Pathways		Platelet homeostasis Phagosomal maturation (early endosomal stage) Latent infection of Homo sapiens with Mycobacterium tuberculosis Nitric oxide stimulates guanylate cyclase	G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Class A/1 (Rhodopsin-like receptors) Amine ligand-binding receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding G alpha (q) signalling events GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK Adrenoceptors G alpha (12/13) signalling events
Drugs		L-Citrulline L-N(Omega)-Nitroarginine-2,4-L-Diaminobutyric Amide Formic Acid 3-Bromo-7-Nitroindazole N-{(4s)-4-Amino-5-[(2-Aminoethyl)Amino]Pentyl}-N\'-Nitroguanidine N-(3-(Aminomethyl)Benzyl)Acetamidine L-N(Omega)-Nitroarginine-(4r)-Amino-L-Proline Amide N-Isopropyl-N\'-Hydroxyguanidine N-Omega-Propyl-L-Arginine (6r,1\'r,2\'s)-5,6,7,8 Tetrahydrobiopterin N-Butyl-N\'-Hydroxyguanidine Alpha-D-Mannose S-Ethyl-N-[4-(Trifluoromethyl)Phenyl]Isothiourea Heme N-Omega-Hydroxy-L-Arginine Flavin-Adenine Dinucleotide Riboflavin Monophosphate N-(4-(2-((3-Chlorophenylmethyl)Amino)Ethyl)Phenyl)-2-Thiophecarboxamidine 2\'-Monophosphoadenosine 5\'-Diphosphoribose S-Ethyl-N-Phenyl-Isothiourea N5-(1-Imino-3-Butenyl)-L-Ornithine 5-N-Allyl-Arginine Nitroarginine N-{(3S,4S)-4-[(6-AMINO-4-METHYLPYRIDIN-2-YL)METHYL]PYRROLIDIN-3-YL}-N\'-(4-CHLOROBENZYL)ETHANE-1,2-DIAMINE N-{(3R,4S)-4-[(6-amino-4-methylpyridin-2-yl)methyl]pyrrolidin-3-yl}-N\'-(3-chlorobenzyl)ethane-1,2-diamine	Midodrine Ziprasidone Dapiprazole Olanzapine Alfuzosin Clozapine Norepinephrine Phenylephrine Promazine Prazosin Chlorpromazine Doxazosin Labetalol Nicardipine Epinephrine Thioridazine Ergotamine Tamsulosin Methoxamine Trimipramine Risperidone Modafinil Propiomazine Doxepin Nefazodone Terazosin Pergolide Bromocriptine Quetiapine Aripiprazole Lisdexamfetamine Paliperidone Methotrimeprazine Dextroamphetamine Phendimetrazine Propericiazine Acepromazine Thioproperazine Dronedarone Sertindole Silodosin Droxidopa Xylometazoline
Diseases
GWAS
Protein-Protein Interactions		33 interactors: ADRA1A ADRA1B ADRA1D ADRB1 ADRB2 ARG1 ATP2B4 BDKRB2 CAMK1 CAMK2A CAMK4 CAV3 CTBP1 DLG2 DLG4 DLGAP2 DYNLL1 HMOX1 HSP90AA1 NOS1AP NOSIP PFKM PRKACA PRKCA PTPN6 PTPRN RASD1 SNTA1 STUB1 SUMO1 SYN1 VAC14 ZDHHC23	11 interactors: ADRA1A AP2M1 EZR FLNC GNA11 GNAQ NOS1 PPP1R9B PRKCA SAG STAT1
Entrez ID		4842	147
HPRD ID		01226	00080
Ensembl ID		ENSG00000089250
Uniprot IDs		A0PJJ7 B3VK56 B4DG68 P29475	P35368
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Heart Contraction Regulation Of The Force Of Heart Contraction Regulation Of Heart Rate Adrenergic Receptor Signaling Pathway Regulation Of Muscle Contraction Cell-cell Signaling Regulation Of Catalytic Activity Regulation Of Ion Transport Regulation Of Cardiac Muscle Hypertrophy Regulation Of Blood Vessel Size Regulation Of Tube Size Regulation Of Cardiac Muscle Contraction Regulation Of Signaling Regulation Of Striated Muscle Contraction Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of The Force Of Heart Contraction By Epinephrine-norepinephrine Regulation Of Phosphorus Metabolic Process Signaling Cell Communication Regulation Of Cellular Localization Positive Regulation Of The Force Of Heart Contraction By Chemical Signal Chemical Homeostasis Regulation Of Metabolic Process Negative Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Heart Rate By Epinephrine-norepinephrine Regulation Of Systemic Arterial Blood Pressure By Baroreceptor Feedback Signal Transduction Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Cellular Metabolic Process Cellular Metal Ion Homeostasis Synaptic Transmission Regulation Of Oxidoreductase Activity Regulation Of Phosphorylation Activation Of Adenylate Cyclase Activity Cellular Response To Stimulus Cellular Cation Homeostasis Homeostatic Process Cellular Calcium Ion Homeostasis Vasoconstriction Cellular Ion Homeostasis Regulation Of Blood Pressure Calcium Ion Homeostasis Regulation Of The Force Of Heart Contraction By Chemical Signal Regulation Of Signal Transduction Cytosolic Calcium Ion Homeostasis Cellular Localization Metal Ion Homeostasis Blood Circulation Positive Regulation Of Adenylate Cyclase Activity Regulation Of Calcium Ion Transport	Regulation Of The Force Of Heart Contraction Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Anatomical Structure Development Activation Of Phospholipase C Activity Positive Regulation Of Phospholipase C Activity Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Response To External Stimulus Developmental Process Positive Regulation Of Phospholipase Activity Phospholipase C-activating Dopamine Receptor Signaling Pathway Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Regulation Of Melanocyte Differentiation Negative Regulation Of Catalytic Activity Cell Differentiation Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Blood Coagulation Hemostasis Filopodium Assembly Regulation Of Epithelial Cell Differentiation G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Signal Transduction Regulation Of Muscle Contraction Regulation Of Developmental Pigmentation Regulation Of Heart Contraction Regulation Of Rhodopsin Mediated Signaling Pathway Regulation Of Signal Transduction Negative Regulation Of Signal Transduction Response To Abiotic Stimulus Intracellular Signal Transduction Signaling Platelet Activation Rhodopsin Mediated Signaling Pathway System Development Cell Communication G-protein Coupled Receptor Signaling Pathway Regulation Of Body Fluid Levels Negative Regulation Of Signaling Wound Healing Dopamine Receptor Signaling Pathway Regulation Of Signaling Cell Surface Receptor Signaling Pathway Locomotion Response To Stimulus Response To Wounding Positive Regulation Of Lyase Activity Negative Regulation Of Blood Pressure Multicellular Organismal Development Regulation Of Catalytic Activity Cellular Response To Stimulus
Tagcloud ?		adenine afterload arrhythmias arrhythmogenic camkii cardiomyocyte cardiomyocytes cardiomyopathy contract contractility contraction counter diastole dinucleotide heartbeat hypertrophic imposes mechanochemotransduction mechanotransduction nicotinamide nnos nos3 nox2 ryanodine ryr sarcoplasmic sparks super transducing	adrenergic agonists angiogenesis biodistribution chemokine cognate cxcr1 distributed gpcr gpcrs hemostasis intractable lipidated loops par1 pathophysiological penetrating pepducins pharmacodynamic pharmacokinetic pharmacology possess protease s1p3 sepsis sphingosine superfamily thrombosis vital
Tagcloud (Difference) ?		adenine afterload arrhythmias arrhythmogenic camkii cardiomyocyte cardiomyocytes cardiomyopathy contract contractility contraction counter diastole dinucleotide heartbeat hypertrophic imposes mechanochemotransduction mechanotransduction nicotinamide nnos nos3 nox2 ryanodine ryr sarcoplasmic sparks super transducing	adrenergic agonists angiogenesis biodistribution chemokine cognate cxcr1 distributed gpcr gpcrs hemostasis intractable lipidated loops par1 pathophysiological penetrating pepducins pharmacodynamic pharmacokinetic pharmacology possess protease s1p3 sepsis sphingosine superfamily thrombosis vital
Tagcloud (Intersection) ?