GLUD1 and KLHL22

Number of citations of the paper that reports this interaction (PubMedID 37788672)
0

Data Source:
BioGRID (enzymatic study)

		GLUD1	KLHL22
Description		glutamate dehydrogenase 1	kelch like family member 22
Image
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix Endoplasmic Reticulum	Nucleus Cytoplasm Lysosome Centrosome Spindle Polar Microtubule Cytosol Cytoskeleton Microtubule Cytoskeleton Cul3-RING Ubiquitin Ligase Complex Intercellular Bridge Mitotic Spindle
	Molecular Function	Nucleotide Binding Glutamate Dehydrogenase (NAD+) Activity Glutamate Dehydrogenase [NAD(P)+] Activity Glutamate Dehydrogenase (NADP+) Activity Protein Binding ATP Binding GTP Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-NH2 Group Of Donors, NAD Or NADP As Acceptor Protein Homodimerization Activity ADP Binding NAD+ Binding L-leucine Binding	Protein Binding 14-3-3 Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Amino Acid Metabolic Process Glutamate Biosynthetic Process L-glutamate Catabolic Process Glutamine Metabolic Process Substantia Nigra Development Positive Regulation Of Insulin Secretion Tricarboxylic Acid Metabolic Process	Mitotic Sister Chromatid Segregation Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of Autophagy Protein Ubiquitination Positive Regulation Of Cell Growth Cellular Response To Nutrient Levels Negative Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Cellular Response To Amino Acid Starvation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of T Cell Activation Positive Regulation Of T Cell Activation Cell Division Cellular Response To Amino Acid Stimulus Cellular Response To L-leucine Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling
Pathways		Transcriptional activation of mitochondrial biogenesis Glutamate and glutamine metabolism Mitochondrial protein degradation	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Glutamic acid NADH Hexachlorophene Guanosine-5'-Triphosphate Aluminum chloride
Diseases
GWAS		Renal underexcretion gout ( 32238385)	Lung function (FEV1/FVC) ( 30061609) Retinopathy in non-diabetics ( 23393555)
Interacting Genes		16 interacting genes: ASGR2 CRP CUL3 DYNLL1 GOT2 HPX HSD17B10 KLHL22 LSM1 NR4A1 OGT ORM1 RNF213 STAT5A TIAM1 VTN	6 interacting genes: ADRA1A CUL3 DEPDC5 GLUD1 PLK1 RBX1
Entrez ID		2746	84861
HPRD ID		11748	07858
Ensembl ID		ENSG00000148672	ENSG00000099910
Uniprot IDs		E9KL48 P00367	Q53GT1
PDB IDs		1L1F 1NR1 6DQG 7UZM 8KGY 8SK8 8W4J	8K8T 8K9I 8KHP 8W4J
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Gene Expression Non-canonical Inflammasome Complex Assembly Polar Microtubule Epithelial Cell Differentiation Involved In Prostate Gland Development Positive Regulation Of TORC1 Signaling Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Multicellular Organismal Process Positive Regulation Of TOR Signaling Regulation Of TORC1 Signaling Inflammatory Response Cell-matrix Adhesion Cellular Component Assembly Transcription By RNA Polymerase II Defense Response Response To Peptide Hormone Blood Microparticle Catabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Lymphocyte Mediated Immunity Mitotic Spindle Positive Regulation Of Biosynthetic Process Asialoglycoprotein Receptor Activity Cell Surface Receptor Signaling Pathway Immune System Process Regulation Of Cytokine Production Negative Regulation Of Developmental Process Positive Regulation Of Macromolecule Metabolic Process Acute-phase Response Regulation Of Multicellular Organismal Process Response To Stress Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Mononuclear Cell Proliferation Acute Inflammatory Response DNA-templated Transcription Mesenchymal Stem Cell Differentiation Nucleobase-containing Compound Metabolic Process Positive Regulation Of Determination Of Dorsal Identity Negative Regulation Of Mitotic Cell Cycle, Embryonic Beta-catenin-ICAT Complex Cellular Response To Oxygen-containing Compound Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Gastrulation Positive Regulation Of Cell Population Proliferation Regulation Of Protein Ubiquitination Positive Regulation Of Cell Communication Glial Cell Fate Determination Oligodendrocyte Differentiation	Cellular Response To Amino Acid Starvation Cul3-RING Ubiquitin Ligase Complex Negative Regulation Of TORC1 Signaling Response To Amino Acid Starvation Positive Regulation Of TORC1 Signaling Negative Regulation Of TOR Signaling Positive Regulation Of TOR Signaling Regulation Of TORC1 Signaling Positive Regulation Of Protein Ubiquitination Positive Regulation Of Post-translational Protein Modification Cullin-RING Ubiquitin Ligase Complex Mitotic Cell Cycle Phase Transition Regulation Of TOR Signaling Cell Cycle Phase Transition RNA Polymerase II Transcription Initiation Surveillance Renal Sodium Ion Absorption Cellular Response To Starvation Renal Sodium Ion Transport Regulation Of Protein Ubiquitination Response To Starvation Regulation Of Post-translational Protein Modification Positive Regulation Of Cell Communication Intracellular Signal Transduction Positive Regulation Of Signaling Positive Regulation Of Protein Metabolic Process Nuclear RNA Surveillance Cellular Response To Nutrient Levels RNA Surveillance Renal Absorption Negative Regulation Of Type I Interferon Production Transcription Elongation By RNA Polymerase II Type I Interferon-mediated Signaling Pathway DNA-templated Transcription Elongation Protein Monoubiquitination Protein Destabilization Regulation Of Mitotic Sister Chromatid Separation Regulation Of Autophagy Positive Regulation Of Protein Modification Process TORC1 Signaling Interferon-mediated Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Regulation Of Chromosome Separation Regulation Of Cellular Response To Insulin Stimulus Negative Regulation Of Heart Rate Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Cellular Response To Amino Acid Stimulus TOR Signaling Regulation Of Cytokinesis
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