GLUD1 and GOT2

Number of citations of the paper that reports this interaction (PubMedID 3997814)
0

Data Source:
HPRD (in vivo)

		GLUD1	GOT2
Description		glutamate dehydrogenase 1	glutamic-oxaloacetic transaminase 2
Image
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix Endoplasmic Reticulum	Mitochondrion Mitochondrial Matrix Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	Nucleotide Binding Glutamate Dehydrogenase (NAD+) Activity Glutamate Dehydrogenase [NAD(P)+] Activity Glutamate Dehydrogenase (NADP+) Activity Protein Binding ATP Binding GTP Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-NH2 Group Of Donors, NAD Or NADP As Acceptor Protein Homodimerization Activity ADP Binding NAD+ Binding L-leucine Binding	RNA Binding Catalytic Activity L-aspartate:2-oxoglutarate Aminotransferase Activity Transaminase Activity Kynurenine-oxoglutarate Transaminase Activity Transferase Activity Pyridoxal Phosphate Binding
	Biological Process	Amino Acid Metabolic Process Glutamate Biosynthetic Process L-glutamate Catabolic Process Glutamine Metabolic Process Substantia Nigra Development Positive Regulation Of Insulin Secretion Tricarboxylic Acid Metabolic Process	2-oxoglutarate Metabolic Process Oxaloacetate Metabolic Process Amino Acid Metabolic Process Aspartate Metabolic Process Aspartate Biosynthetic Process L-aspartate Catabolic Process Glutamate Metabolic Process L-glutamate Catabolic Process Lipid Transport Fatty Acid Transport Trans-4-hydroxy-L-proline Catabolic Process L-glutamate Catabolic Process To Aspartate Malate-aspartate Shuttle Response To Ethanol
Pathways		Transcriptional activation of mitochondrial biogenesis Glutamate and glutamine metabolism Mitochondrial protein degradation	Degradation of cysteine and homocysteine Glyoxylate metabolism and glycine degradation Aspartate and asparagine metabolism Glutamate and glutamine metabolism Malate-aspartate shuttle
Drugs		Glutamic acid NADH Hexachlorophene Guanosine-5'-Triphosphate Aluminum chloride	Pyridoxal phosphate Aspartic acid Glutamic acid Cysteine 4'-Deoxy-4'-Acetylyamino-Pyridoxal-5'-Phosphate
Diseases
GWAS		Renal underexcretion gout ( 32238385)	Aortic root size ( 21223598) Aspartate aminotransferase levels ( 29403010 33339817 33547301) Automobile speeding propensity ( 30643258) High density lipoprotein cholesterol levels ( 33339817) Impulsivity (attentional) ( 30718321) Metabolite levels ( 23823483) QT interval ( 19305408) Serum metabolite levels ( 33031748) Triglyceride levels ( 32203549) Urinary metabolite levels in chronic kidney disease ( 31959995) Uterine fibroid number (single vs multiple) ( 30196971)
Interacting Genes		16 interacting genes: ASGR2 CRP CUL3 DYNLL1 GOT2 HPX HSD17B10 KLHL22 LSM1 NR4A1 OGT ORM1 RNF213 STAT5A TIAM1 VTN	10 interacting genes: APCS CCL21 GAPDH GLRX GLUD1 HSPA8 MDH2 PC THOC7 ZDHHC6
Entrez ID		2746	2806
HPRD ID		11748	00684
Ensembl ID		ENSG00000148672	ENSG00000125166
Uniprot IDs		E9KL48 P00367	P00505
PDB IDs		1L1F 1NR1 6DQG 7UZM 8KGY 8SK8 8W4J	5AX8 8SKR
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Gene Expression Non-canonical Inflammasome Complex Assembly Polar Microtubule Epithelial Cell Differentiation Involved In Prostate Gland Development Positive Regulation Of TORC1 Signaling Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Multicellular Organismal Process Positive Regulation Of TOR Signaling Regulation Of TORC1 Signaling Inflammatory Response Cell-matrix Adhesion Cellular Component Assembly Transcription By RNA Polymerase II Defense Response Response To Peptide Hormone Blood Microparticle Catabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Lymphocyte Mediated Immunity Mitotic Spindle Positive Regulation Of Biosynthetic Process Asialoglycoprotein Receptor Activity Cell Surface Receptor Signaling Pathway Immune System Process Regulation Of Cytokine Production Negative Regulation Of Developmental Process Positive Regulation Of Macromolecule Metabolic Process Acute-phase Response Regulation Of Multicellular Organismal Process Response To Stress Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Mononuclear Cell Proliferation Acute Inflammatory Response DNA-templated Transcription Mesenchymal Stem Cell Differentiation Nucleobase-containing Compound Metabolic Process Positive Regulation Of Determination Of Dorsal Identity Negative Regulation Of Mitotic Cell Cycle, Embryonic Beta-catenin-ICAT Complex Cellular Response To Oxygen-containing Compound Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Gastrulation Positive Regulation Of Cell Population Proliferation Regulation Of Protein Ubiquitination Positive Regulation Of Cell Communication Glial Cell Fate Determination Oligodendrocyte Differentiation	Glucose Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Nicotinamide Nucleotide Metabolic Process Purine Nucleotide Metabolic Process Nucleotide Metabolic Process Hexose Metabolic Process Small Molecule Metabolic Process Monosaccharide Metabolic Process Purine-containing Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Nucleoside Phosphate Metabolic Process Chaperone-mediated Autophagy Translocation Complex Disassembly NAD+ Metabolic Process L-malate Dehydrogenase (NADP+) Activity Hexose Biosynthetic Process Gluconeogenesis Pyruvate Carboxylase Activity Dendritic Cell Dendrite Assembly Negative Regulation Of Dendritic Cell Dendrite Assembly Host-mediated Perturbation Of Viral Process Negative Regulation By Host Of Viral Glycoprotein Metabolic Process Peptidyl-cysteine S-trans-nitrosylation Glyceraldehyde-3-phosphate Dehydrogenase (NAD+) (phosphorylating) Activity Glutathione Disulfide Oxidoreductase Activity Glutamate Dehydrogenase (NAD+) Activity Oxidoreductase Activity, Acting On The CH-NH2 Group Of Donors, NAD Or NADP As Acceptor Glutamate Dehydrogenase (NADP+) Activity Glutamate Dehydrogenase [NAD(P)+] Activity Lumenal Side Of Lysosomal Membrane Viral RNA Genome Packaging Positive Regulation Of Myeloid Dendritic Cell Chemotaxis Mesangial Cell-matrix Adhesion CCR7 Chemokine Receptor Binding CCL21-activated CCR7 Signaling Pathway Cerebral Cortex Development Dicarboxylic Acid Metabolic Process Protein Kinase CK2 Complex Peptidyl-cysteine S-nitrosylase Activity Regulation Of Protein Import L-malate Dehydrogenase (NAD+) Activity Malate Dehydrogenase Activity Regulation Of Dendritic Cell Dendrite Assembly Unfolded Protein Binding Host-mediated Perturbation Of Symbiont Process Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Carbohydrate Metabolic Process Peptidyl-cysteine S-nitrosylation GAIT Complex Mitochondrial Matrix Protein Targeting To Lysosome Involved In Chaperone-mediated Autophagy
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