GLUD1 and NR4A1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		GLUD1	NR4A1
Description		glutamate dehydrogenase 1	nuclear receptor subfamily 4 group A member 1
Image
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix Endoplasmic Reticulum	Chromatin Fibrillar Center Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Mitochondrion Cytosol Nuclear Speck Nuclear Membrane
	Molecular Function	Nucleotide Binding Glutamate Dehydrogenase (NAD+) Activity Glutamate Dehydrogenase [NAD(P)+] Activity Glutamate Dehydrogenase (NADP+) Activity Protein Binding ATP Binding GTP Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-NH2 Group Of Donors, NAD Or NADP As Acceptor Protein Homodimerization Activity ADP Binding NAD+ Binding L-leucine Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Lipopolysaccharide Binding DNA Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Nuclear Glucocorticoid Receptor Binding Identical Protein Binding Sequence-specific DNA Binding Metal Ion Binding Protein Heterodimerization Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Amino Acid Metabolic Process Glutamate Biosynthetic Process L-glutamate Catabolic Process Glutamine Metabolic Process Substantia Nigra Development Positive Regulation Of Insulin Secretion Tricarboxylic Acid Metabolic Process	Positive Regulation Of Endothelial Cell Proliferation Cell Migration Involved In Sprouting Angiogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Protein Import Into Nucleus Apoptotic Process Inflammatory Response Signal Transduction Intracellular Receptor Signaling Pathway Detection Of Lipopolysaccharide Endothelial Cell Chemotaxis Skeletal Muscle Cell Differentiation Cellular Response To Vascular Endothelial Growth Factor Stimulus Macrophage Activation Positive Regulation Of Apoptotic Process Cellular Response To Fibroblast Growth Factor Stimulus Fat Cell Differentiation Negative Regulation Of Cell Cycle Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Type B Pancreatic Cell Proliferation Cellular Response To Corticotropin-releasing Hormone Stimulus Non-canonical Inflammasome Complex Assembly
Pathways		Transcriptional activation of mitochondrial biogenesis Glutamate and glutamine metabolism Mitochondrial protein degradation	AKT phosphorylates targets in the nucleus Nuclear Receptor transcription pathway Constitutive Signaling by AKT1 E17K in Cancer
Drugs		Glutamic acid NADH Hexachlorophene Guanosine-5'-Triphosphate Aluminum chloride
Diseases
GWAS		Renal underexcretion gout ( 32238385)
Interacting Genes		16 interacting genes: ASGR2 CRP CUL3 DYNLL1 GOT2 HPX HSD17B10 KLHL22 LSM1 NR4A1 OGT ORM1 RNF213 STAT5A TIAM1 VTN	86 interacting genes: ABCA5 ABCB11 ABCC13 ABCC6 ABCG8 AKT1 ANKIB1 ARHGEF10L ARHGEF5 ATM ATXN1 BBS10 BCL2 BCL2A1 BCL2L10 CD2AP CDKN2D CHD1L CHD3 CHEK2 CPT1A CUTA DIABLO EP300 FAF1 FXYD3 GADD45GIP1 GK GLOD4 GLUD1 HADHA HES1 HIF1A HNRNPA2B1 HSP90AB1 KAT2B KRTAP10-1 KRTAP10-5 LONRF1 LSS MAP3K1 MAPK1 MAPK8 MED1 MED31 NACAD NCOA1 NCOA2 NCOA3 NCOR2 NDRG1 NFKB1 NR3C1 PGBD1 PML POLA2 PPARG PPBP PPM1A PRDX4 PRDX6 RBL1 ROBO2 RPL7 RPS6KA1 RPS6KA3 RPS6KA5 RPS6KA6 RTN4 RXRA RXRG SERPINA4 SERPING1 SOCS4 STAT3 SUGT1 TCF4 TP53 TRAF2 TRIM28 TUBB4A VASP VHL YWHAZ ZNF331 ZNF579
Entrez ID		2746	3164
HPRD ID		11748	00744
Ensembl ID		ENSG00000148672	ENSG00000123358
Uniprot IDs		E9KL48 P00367	F5GXF0 P22736 Q6ZMM6
PDB IDs		1L1F 1NR1 6DQG 7UZM 8KGY 8SK8 8W4J	2QW4 3V3E 3V3Q 4JGV 4KZI 4KZJ 4KZM 4RE8 4REE 4REF 4RZE 4RZF 4RZG 4WHF 4WHG 6KZ5 6LC1 8WUY 8Y7L
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Gene Expression Non-canonical Inflammasome Complex Assembly Polar Microtubule Epithelial Cell Differentiation Involved In Prostate Gland Development Positive Regulation Of TORC1 Signaling Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Multicellular Organismal Process Positive Regulation Of TOR Signaling Regulation Of TORC1 Signaling Inflammatory Response Cell-matrix Adhesion Cellular Component Assembly Transcription By RNA Polymerase II Defense Response Response To Peptide Hormone Blood Microparticle Catabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Lymphocyte Mediated Immunity Mitotic Spindle Positive Regulation Of Biosynthetic Process Asialoglycoprotein Receptor Activity Cell Surface Receptor Signaling Pathway Immune System Process Regulation Of Cytokine Production Negative Regulation Of Developmental Process Positive Regulation Of Macromolecule Metabolic Process Acute-phase Response Regulation Of Multicellular Organismal Process Response To Stress Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Mononuclear Cell Proliferation Acute Inflammatory Response DNA-templated Transcription Mesenchymal Stem Cell Differentiation Nucleobase-containing Compound Metabolic Process Positive Regulation Of Determination Of Dorsal Identity Negative Regulation Of Mitotic Cell Cycle, Embryonic Beta-catenin-ICAT Complex Cellular Response To Oxygen-containing Compound Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Gastrulation Positive Regulation Of Cell Population Proliferation Regulation Of Protein Ubiquitination Positive Regulation Of Cell Communication Glial Cell Fate Determination Oligodendrocyte Differentiation	Intracellular Signal Transduction Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Programmed Cell Death Regulation Of Apoptotic Process TOR Signaling Positive Regulation Of RNA Metabolic Process TORC1 Signaling Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Intracellular Receptor Signaling Pathway Response To Lipid Peroxisome Proliferator Activated Receptor Signaling Pathway Nuclear Receptor-mediated Signaling Pathway Nuclear Receptor Binding Ubiquitin Protein Ligase Binding Programmed Cell Death Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Cell Death Positive Regulation Of Biosynthetic Process Protein-containing Complex Cellular Response To Stress Positive Regulation Of Macromolecule Metabolic Process Regulation Of Small Molecule Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Metabolic Process Apoptotic Process Negative Regulation Of Programmed Cell Death Nucleoplasm Intrinsic Apoptotic Signaling Pathway Response To Nutrient Levels Identical Protein Binding MRNA Transcription Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Biosynthetic Process Negative Regulation Of Apoptotic Process Regulation Of Protein Stability Response To Decreased Oxygen Levels Negative Regulation Of RNA Metabolic Process Response To Hormone Negative Regulation Of Nucleobase-containing Compound Metabolic Process Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Developmental Process Response To Oxygen Levels MRNA Transcription By RNA Polymerase II DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Primary Metabolic Process
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