KANK2 and CDKL3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KANK2	CDKL3
Description		KN motif and ankyrin repeat domains 2	cyclin dependent kinase like 3
Image
GO Annotations	Cellular Component	Cytoplasm Mitochondrion	Nucleus Cytoplasm
	Molecular Function	Protein Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Apoptotic Process Negative Regulation Of Cell Population Proliferation Negative Regulation Of Actin Filament Polymerization Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Regulation Of Rho Protein Signal Transduction Negative Regulation Of Programmed Cell Death Negative Regulation Of Vitamin D Receptor Signaling Pathway Kidney Epithelium Development Podocyte Cell Migration Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Negative Regulation Of Axon Extension Protein Modification Process Positive Regulation Of Dendrite Morphogenesis Regulation Of Cell Cycle Dendrite Extension
Pathways
Drugs
Diseases
GWAS		Apolipoprotein B levels ( 32203549) Cholesterol, total ( 26780889) Coronary artery disease ( 29212778) HDL cholesterol ( 23505323) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 27863252 32888494) Intraocular pressure ( 31959993) Low density lipoprotein cholesterol levels ( 32154731 32902719) Mean spheric corpuscular volume ( 32888494) Non-HDL cholesterol levels ( 32902719) Red cell distribution width ( 28957414 32888494 27863252) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Triglyceride levels ( 32203549)	Eosinophil count ( 27863252) Moderate-to-late spontaneous preterm birth ( 31194736)
Interacting Genes		187 interacting genes: ABI3 AEN ANKRD11 AP2B1 ARL14EP ASB15 BEND7 BIRC7 BLZF1 BORCS6 C2orf68 CADPS CAMK2G CAPN3 CARD10 CARD9 CBX8 CCDC33 CCDC57 CCDC88B CDC20B CDC5L CDKL3 CEACAM6 CEP55 CEP63 CEP70 CFAP68 CHCHD3 CHIC2 CINP COG6 CRX CSNK2A1 CUTC CWF19L2 CYTH4 DDIT4L DLGAP3 DPEP2NB DTX2 DYNLL1 EFHC2 EIF4E ELOA EXOSC8 FAM161A FAM90A1 FHL2 FHL3 FKBP6 GADD45GIP1 GATA1 GEMIN4 GKAP1 GMCL1 GMNN GOLGA2 GOLGA6A GOLGA6L9 GPANK1 GPKOW GPSM1 GRB10 HAND2 HOMER3 HSF2BP HSPB2 HSPB2-C11orf52 IHO1 IKZF3 IL16 KIF9 KIFAP3 KIFC3 KRT27 KRT31 KRT34 KRT40 KRT75 KRT86 KRTAP6-3 L3MBTL3 LBX1 LENG1 LHX1 LHX3 LMO1 LMO2 LMO3 LMO4 LZTS1 MAGEB4 MCCD1 MCRS1 MED19 MEOX1 MEOX2 MID2 MITD1 MKRN3 MOB1A MOB3C MORN3 MSS51 MTUS2 MYOZ3 NCOA1 NCOA5 NECAB2 NOS3 NRIP1 NUTM1 OIP5 PAX6 PCBD1 PDE9A PDLIM7 PFDN6 PIBF1 PLAGL2 PLEKHA2 PNKP PPP1CB PRDM14 PRDM6 PRKAR1B PRMT5 PRPF18 PRPF31 PRR5L PSEN1 PSMB4 PSTPIP1 RAB11FIP2 RALBP1 RBCK1 RHOH SCARA5 SCNM1 SERTAD3 SNAPIN SNW1 SORBS3 SRPK2 STAC SYT6 TAX1BP1 TEX11 TFIP11 TGM5 THAP1 THAP6 TIFA TLE5 TOP3B TRAF1 TRAF2 TRAF4 TRIB3 TRIM35 TRIM54 TSGA10 TSGA10IP TSPYL6 TXLNA UBAP2 UBC USHBP1 UTP14C VMAC VPS52 VWC2 WASF3 WASHC1 ZBTB42 ZFP57 ZMAT2 ZMYND12 ZNF212 ZNF414 ZNF512 ZNF648 ZNF774 ZNF784 ZNHIT1 ZRANB1	31 interacting genes: APP ATG4A CYSRT1 DISC1 DNAAF6 FXR1 FXR2 GGA1 GOLGA2 IKZF1 KANK2 KASH5 KRTAP10-9 LRP2BP LRRK2 LZTS2 MCC MDFI MTUS2 PICK1 PIH1D2 RABEP1 SNRNP70 SRPK1 TRIM27 TRIM37 TTF2 ZBTB14 ZBTB43 ZBTB8A ZRANB1
Entrez ID		25959	51265
HPRD ID		12463	09766
Ensembl ID		ENSG00000197256	ENSG00000006837
Uniprot IDs		Q63ZY3	B4DX41 Q8IVW4
PDB IDs		4HBD 5YBV 6TMD	3ZDU
Enriched GO Terms of Interacting Partners?		Protein Binding Identical Protein Binding Nucleus Structural Constituent Of Skin Epidermis	Regulation Of Wnt Signaling Pathway Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Regulation Of Long-term Neuronal Synaptic Plasticity Negative Regulation Of Autophagy Positive Regulation Of Catabolic Process Protein Localization To Ciliary Membrane Cellular Response To Manganese Ion Positive Regulation Of Long-term Neuronal Synaptic Plasticity Wnt Signaling Pathway Regulation Of Neuronal Synaptic Plasticity Cellular Component Assembly Negative Regulation Of Long-term Synaptic Potentiation Identical Protein Binding Negative Regulation Of Wnt Signaling Pathway Modulation Of Chemical Synaptic Transmission Protein Homodimerization Activity Cellular Localization Response To Manganese Ion Neuron Projection Regulation Of Receptor Internalization Cytoplasm Regulation Of Synaptic Transmission, Glutamatergic Golgi-associated Vesicle Cellular Response To Catecholamine Stimulus Translation Regulator Activity Regulation Of Synaptic Plasticity Positive Regulation Of Protein Metabolic Process Response To Catecholamine Negative Regulation Of Catabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Postsynapse Presynapse Regulation Of Primary Metabolic Process Dentate Gyrus Development Regulation Of Canonical Wnt Signaling Pathway Intracellular Transport Positive Regulation Of Receptor Internalization Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Negative Regulation Of Transcription By RNA Polymerase II Amylin Binding Positive Regulation Of Toll Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Receptor-mediated Endocytosis Negative Regulation Of Macromolecule Metabolic Process Organelle Assembly Aggresome
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