KANK2 and EIF4E

Number of citations of the paper that reports this interaction (PMID 24722188)
1

Data Source:
BioGRID (two hybrid, two hybrid)

		KANK2	EIF4E
Gene Name		KN motif and ankyrin repeat domains 2	eukaryotic translation initiation factor 4E
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Mitochondrion	Cytoplasmic MRNA Processing Body Cytoplasm Cytosol MRNA Cap Binding Complex Cytoplasmic Stress Granule Eukaryotic Translation Initiation Factor 4F Complex RISC Complex Chromatoid Body Extracellular Vesicular Exosome
	Molecular Function	Protein Binding	RNA Cap Binding Translation Initiation Factor Activity Protein Binding Eukaryotic Initiation Factor 4G Binding Poly(A) RNA Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Apoptotic Process Negative Regulation Of Cell Proliferation Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Negative Regulation Of Programmed Cell Death Negative Regulation Of Vitamin D Receptor Signaling Pathway Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	G1/S Transition Of Mitotic Cell Cycle Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening MRNA Export From Nucleus Translation Translational Initiation Regulation Of Translation Insulin Receptor Signaling Pathway Gene Expression Viral Process Cytokine-mediated Signaling Pathway Lung Development Cellular Protein Metabolic Process Positive Regulation Of Mitotic Cell Cycle
Pathways			Translation initiation complex formation IRS-mediated signalling mTOR signalling Transport of the SLBP independent Mature mRNA mTOR signalling mTORC1-mediated signalling IGF1R signaling cascade Deadenylation-dependent mRNA decay IRS-related events triggered by IGF1R Eukaryotic Translation Initiation Release of eIF4E Transport of Mature Transcript to Cytoplasm Cap-dependent Translation Initiation PKB-mediated events PI3K Cascade Signaling by Insulin receptor Transport of Mature mRNA Derived from an Intronless Transcript Processing of Capped Intron-Containing Pre-mRNA Transport of the SLBP Dependant Mature mRNA Insulin receptor signalling cascade Deadenylation of mRNA Translation Transport of Mature mRNA derived from an Intron-Containing Transcript ISG15 antiviral mechanism Transport of Mature mRNAs Derived from Intronless Transcripts Interferon Signaling Cytokine Signaling in Immune system IRS-related events Release of eIF4E L13a-mediated translational silencing of Ceruloplasmin expression Antiviral mechanism by IFN-stimulated genes mTORC1-mediated signalling Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S PKB-mediated events PI3K Cascade
Drugs			7-Methyl-Gpppa 7n-Methyl-8-Hydroguanosine-5\'-Diphosphate 7-Methyl-Guanosine-5\'-Triphosphate 2,2,5,5-TETRAMETHYL-3-(SULFANYLMETHYL)-2,5-DIHYDRO-1H-PYRROL-1-OL
Diseases
GWAS		HDL cholesterol ( 23505323)
Protein-Protein Interactions		22 interactors: ABI3 AES CCDC33 CCDC36 CEP70 CSNK2A1 DYNLL1 EIF4E FHL2 GOLGA2 GPSM1 LMO1 LMO2 LMO4 MAGEB4 MOB1A NCOA1 NOS3 PSEN1 STAC TXLNA VPS52	25 interactors: APP CD83 EIF4B EIF4EBP1 EIF4EBP2 EIF4EBP3 EIF4ENIF1 EIF4G1 EIF4G2 EIF4G3 EMX2 GEMIN5 KANK2 MAPKAPK5 MKNK1 MKNK2 PML PRDM4 PRKCA PRKCB PRKCG RPS6KA5 TDO2 TRIM27 UBXN11
Entrez ID		25959	1977
HPRD ID		12463	00591
Ensembl ID		ENSG00000197256
Uniprot IDs		Q63ZY3	P06730 Q32Q75
PDB IDs		4HBD	1IPB 1IPC 1WKW 2GPQ 2V8W 2V8X 2V8Y 2W97 3AM7 3TF2 3U7X 4AZA 4DT6 4DUM
Enriched GO Terms of Interacting Partners?		System Development Organ Development Anatomical Structure Morphogenesis Multicellular Organismal Development Anatomical Structure Development Regulation Of Apoptotic Process Regulation Of Cell Death Tube Development Embryo Development Regulation Of Protein Binding Developmental Process Mitotic Cell Cycle Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Androgen Receptor Signaling Pathway Embryonic Organ Development Cellular Response To Extracellular Stimulus Gene Expression Negative Regulation Of Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Cajal-Retzius Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter By Galactose Beta-amyloid Formation Negative Regulation Of Protein Binding Thymus Development Macromolecule Biosynthetic Process Positive Regulation Of Apoptotic Process Regulation Of Binding Positive Regulation Of Programmed Cell Death Mitotic Cell Cycle Phase Transition Positive Regulation Of Cellular Biosynthetic Process Cell Cycle Phase Transition Positive Regulation Of Cell Death Transcription, DNA-templated Wnt Signaling Pathway Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Cellular Protein Catabolic Process Biosynthetic Process RNA Biosynthetic Process Smooth Muscle Hyperplasia Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Embryonic Ectodermal Digestive Tract Development Rhythmic Process Mitotic Cell Cycle Process RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Atrial Cardiac Muscle Cell Development Regulation Of Cellular Response To Drug	Regulation Of Translation Regulation Of Translational Initiation Posttranscriptional Regulation Of Gene Expression Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Organic Substance Response To Organic Substance Regulation Of Gene Expression Cell Surface Receptor Signaling Pathway Cellular Protein Metabolic Process Signal Transduction Protein Phosphorylation Signaling Cell Communication Regulation Of Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Translational Initiation Histone H3-T6 Phosphorylation Gene Expression Negative Regulation Of Translation Negative Regulation Of Protein Metabolic Process Protein Metabolic Process Translational Initiation Cellular Response To Stimulus Cell Death Death Phosphorylation Intracellular Signal Transduction Histone Phosphorylation Insulin Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Stimulus Negative Regulation Of Cellular Metabolic Process Cellular Metabolic Process Response To Growth Factor Regulation Of Cell Cycle Negative Regulation Of Biosynthetic Process Apoptotic Process Platelet Activation Translation Programmed Cell Death Regulation Of Mitotic Cell Cycle Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Insulin Stimulus Response To Cytokine Neurotrophin Signaling Pathway MRNA 3'-end Processing Cytokine-mediated Signaling Pathway
Tagcloud ?			4g amount bp1 corticosterone decreases deficiency diazoxide diminished dramatic efficiency eif4g epitrochlearis eukaryotic fractional gastrocnemius glucagon hormones initiation injection lowered modulating muscle postprandial ribosomal skeletal soleus synthesis translation
Tagcloud (Difference) ?			4g amount bp1 corticosterone decreases deficiency diazoxide diminished dramatic efficiency eif4g epitrochlearis eukaryotic fractional gastrocnemius glucagon hormones initiation injection lowered modulating muscle postprandial ribosomal skeletal soleus synthesis translation
Tagcloud (Intersection) ?