IL18 and IL18RAP

Number of citations of the paper that reports this interaction (PMID 9792649)
48

Data Source:
HPRD (in vivo)

		IL18	IL18RAP
Gene Name		interleukin 18	interleukin 18 receptor accessory protein
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol Extracellular Vesicular Exosome	Integral Component Of Membrane
	Molecular Function	Cytokine Activity Protein Binding	Receptor Activity
	Biological Process	MAPK Cascade Angiogenesis Inflammatory Response Immune Response Cell-cell Signaling Positive Regulation Of Gene Expression Natural Killer Cell Activation Regulation Of Cell Adhesion Sleep Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Tissue Remodeling Chemokine Biosynthetic Process T-helper 1 Type Immune Response Type 2 Immune Response Interleukin-2 Biosynthetic Process Interferon-gamma Biosynthetic Process Positive Regulation Of Activated T Cell Proliferation Interleukin-13 Biosynthetic Process Granulocyte Macrophage Colony-stimulating Factor Biosynthetic Process Positive Regulation Of NF-kappaB Import Into Nucleus Negative Regulation Of Myoblast Differentiation Positive Regulation Of Inflammatory Response Positive Regulation Of NK T Cell Proliferation Cellular Response To Organic Cyclic Compound	Inflammatory Response Immune Response Cell Surface Receptor Signaling Pathway
Pathways		Signaling by Interleukins Interleukin-1 processing Cytokine Signaling in Immune system
Drugs
Diseases
GWAS		Protein quantitative trait loci ( 18464913)	Atopic dermatitis ( 23042114) Celiac disease ( 20190752 18311140) Crohn's disease ( 21102463) Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		8 interactors: CASK CASP1 CASP3 CASP4 IL18BP IL18R1 IL18RAP IL1RL2	3 interactors: APP CD48 IL18
Entrez ID		3606	8807
HPRD ID		02976	05147
Ensembl ID		ENSG00000150782	ENSG00000115607
Uniprot IDs		Q14116	O95256 Q3KPE8
PDB IDs		1J0S 2VXT 3F62 4EEE 4EKX 4HJJ
Enriched GO Terms of Interacting Partners?		Execution Phase Of Apoptosis Immune System Process Immune Response T-helper 1 Type Immune Response Response To Cytokine Regulation Of Inflammatory Response Cellular Response To Organic Substance Positive Regulation Of Cytokine Production Interleukin-18-mediated Signaling Pathway Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Zymogen Activation Response To Organic Substance Regulation Of Cytokine Production Cellular Response To Interleukin-18 Mitochondrial Depolarization Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Response To Cytokine Stimulus Positive Regulation Of Cysteine-type Endopeptidase Activity Response To Tumor Necrosis Factor Positive Regulation Of Endopeptidase Activity Regulation Of Cell Adhesion Response To Interleukin-18 Positive Regulation Of Interleukin-1 Alpha Secretion Positive Regulation Of Peptidase Activity Positive Regulation Of Transport Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Interleukin-1 Alpha Production Pyroptosis Cellular Response To Oxidative Stress Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cell Adhesion Regulation Of Cysteine-type Endopeptidase Activity Glial Cell Apoptotic Process Response To Stress Regulation Of Apoptotic DNA Fragmentation Regulation Of I-kappaB Kinase/NF-kappaB Signaling Protein Processing Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Apoptotic Process Adaptive Immune Response Programmed Cell Death Negative Regulation Of Keratinocyte Proliferation Cell Death Regulation Of T Cell Activation Death Regulation Of Cellular Process Positive Regulation Of Proteolysis Negative Regulation Of Activated T Cell Proliferation Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C	Granulocyte Macrophage Colony-stimulating Factor Biosynthetic Process Chemokine Biosynthetic Process Interleukin-13 Biosynthetic Process Defense Response Synaptic Growth At Neuromuscular Junction Interferon-gamma Biosynthetic Process Collateral Sprouting In Absence Of Injury Positive Regulation Of NK T Cell Proliferation Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Interleukin-2 Biosynthetic Process Immune System Process Axon Choice Point Recognition Positive Regulation Of Natural Killer Cell Proliferation Regulation Of Natural Killer Cell Proliferation Chemokine Metabolic Process Blood Coagulation Hemostasis Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Neuron Remodeling Interleukin-2 Production Chemokine Production Type 2 Immune Response Positive Regulation Of Interleukin-17 Production Regulation Of Body Fluid Levels Positive Regulation Of Alpha-beta T Cell Proliferation Wound Healing Sleep Cellular Copper Ion Homeostasis Cell Activation Interferon-gamma Production Response To Wounding Positive Regulation Of NF-kappaB Import Into Nucleus Copper Ion Homeostasis Suckling Behavior Negative Regulation Of Cell Differentiation Negative Regulation Of Myoblast Differentiation Positive Regulation Of Activated T Cell Proliferation Cytokine Biosynthetic Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Response To Stress Positive Regulation Of Natural Killer Cell Activation T-helper 1 Type Immune Response Positive Regulation Of Tissue Remodeling Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Cytokine Metabolic Process Mating Behavior
Tagcloud ?		advance comprehensively doi genotyped haplotype household il1b il4 influences kampala nod2 nominal online persistently publication resistors rstr rstrs slc6a3 snps suggestively tagging tb ticam2 tlr4 tlr6 tollip tuberculin uganda	ahsa2 cd coeliac ddx59 egenes elmo1 eprobes eqtl eqtls esnps harbour implies nominal nsf overlapped park7 pbmc rs12727642 rs13003464 rs2074404 rs2298428 rs296547 rs6974491 rs842647 rs917997 snps thymic thymus ube2l3
Tagcloud (Difference) ?		advance comprehensively doi genotyped haplotype household il1b il4 influences kampala nod2 online persistently publication resistors rstr rstrs slc6a3 suggestively tagging tb ticam2 tlr4 tlr6 tollip tuberculin uganda	ahsa2 cd coeliac ddx59 egenes elmo1 eprobes eqtl eqtls esnps harbour implies nsf overlapped park7 pbmc rs12727642 rs13003464 rs2074404 rs2298428 rs296547 rs6974491 rs842647 rs917997 thymic thymus ube2l3
Tagcloud (Intersection) ?		nominal snps