IL18 and ADIRF

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		IL18	ADIRF
Description		interleukin 18	adipogenesis regulatory factor
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Cytosol	Nucleus Nucleoplasm Cytosol Extracellular Exosome
	Molecular Function	Cytokine Activity Protein Binding Interleukin-18 Receptor Binding Receptor Ligand Activity	Protein Binding
	Biological Process	Angiogenesis Inflammatory Response Immune Response Cell Surface Receptor Signaling Pathway Cell-cell Signaling Cell Population Proliferation Positive Regulation Of Gene Expression Positive Regulation Of Macrophage Derived Foam Cell Differentiation Cytokine-mediated Signaling Pathway Natural Killer Cell Activation Regulation Of Cell Adhesion Sleep Positive Regulation Of Chemokine Production Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Tissue Remodeling Interleukin-18-mediated Signaling Pathway T-helper 1 Type Immune Response Type 2 Immune Response Positive Regulation Of Activated T Cell Proliferation Neutrophil Activation Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Cholesterol Homeostasis Positive Regulation Of T-helper 2 Cell Differentiation Negative Regulation Of Myoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Inflammatory Response Defense Response To Gram-positive Bacterium Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of NK T Cell Proliferation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Establishment Of Skin Barrier Triglyceride Homeostasis Cellular Response To Lipopolysaccharide Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Neuroinflammatory Response Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of T-helper 1 Cell Cytokine Production	Cell Differentiation Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Interleukin-1 processing Pyroptosis Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Interleukin-18 signaling Purinergic signaling in leishmaniasis infection CASP4-mediated substrate cleavage CASP5-mediated substrate cleavage	Transcriptional regulation of white adipocyte differentiation
Drugs
Diseases
GWAS		Blood protein levels in cardiovascular risk ( 28369058) Inflammatory biomarkers ( 24182552) Interleukin-18 levels ( 27989323 31584380) Protein quantitative trait loci ( 18464913)
Interacting Genes		9 interacting genes: ADIRF CASK CASP1 CASP3 CASP4 IL18BP IL18R1 IL18RAP IL1RL2	3 interacting genes: GSK3B IL18 RPS6KA6
Entrez ID		3606	10974
HPRD ID		02976	16575
Ensembl ID		ENSG00000150782	ENSG00000148671
Uniprot IDs		Q14116	Q15847
PDB IDs		1J0S 2VXT 3F62 3WO2 3WO3 3WO4 4EEE 4EKX 4HJJ 4R6U 4XFS 4XFT 4XFU 7AL7 8J6K 8SPB 8SV1 8URV
Enriched GO Terms of Interacting Partners?		Interleukin-18-mediated Signaling Pathway Cytokine-mediated Signaling Pathway NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating Inflammatory Response Interleukin-18 Receptor Complex Interleukin-18 Receptor Activity Interleukin-18 Binding Pyroptotic Inflammatory Response NLRP1 Inflammasome Complex Interleukin-1 Receptor Activity Cysteine-type Endopeptidase Activity Immune System Process Cellular Response To Chemical Stress Defense Response Response To Hydrogen Peroxide Canonical Inflammasome Complex Regulation Of Defense Response CARD Domain Binding Pyroptotic Cell Death Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Cysteine-type Peptidase Activity Protein Poly-ADP-ribosylation Regulation Of Inflammatory Response Hydrolase Activity Protein Autoprocessing Positive Regulation Of Defense Response Response To Reactive Oxygen Species Positive Regulation Of Inflammatory Response Interleukin-1-mediated Signaling Pathway Protein Processing Response To Cytokine Response To Peptide Cell Surface Receptor Signaling Pathway Immune Response Response To Stress Response To External Biotic Stimulus Cellular Response To Osmotic Stress Signaling Receptor Activity Adaptive Immune Response Response To Lipopolysaccharide Protein Maturation Positive Regulation Of Cytokine-mediated Signaling Pathway Regulation Of Cytokine Production Response To Molecule Of Bacterial Origin Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Response To Cytokine Stimulus Positive Regulation Of Neuron Apoptotic Process Non-canonical Inflammasome Complex Cellular Response To Interleukin-18 Cellular Response To Hydrogen Peroxide	TORC2 Signaling Negative Regulation Of Calcineurin-NFAT Signaling Cascade Beta-catenin Destruction Complex Negative Regulation Of Glycogen Biosynthetic Process Superior Temporal Gyrus Development TOR Signaling Wnt Signalosome Negative Regulation Of Type B Pancreatic Cell Development ER Overload Response Protein Serine Kinase Activity Regulation Of Protein Localization To Cilium Regulation Of Dopaminergic Neuron Differentiation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Type B Pancreatic Cell Development Regulation Of Protein Localization To Centrosome Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Protein Localization To Cilium Negative Regulation Of Developmental Process Regulation Of Cellular Response To Heat Positive Regulation Of Cell Adhesion Negative Regulation Of Mesenchymal Stem Cell Differentiation Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Protein Binding Negative Regulation Of TORC2 Signaling Maintenance Of Cell Polarity Negative Regulation Of Glycogen (starch) Synthase Activity Regulation Of Microtubule Anchoring At Centrosome Cellular Response To Lipid Regulation Of Mesenchymal Stem Cell Differentiation Negative Regulation Of Dopaminergic Neuron Differentiation Regulation Of TORC2 Signaling Cellular Response To Interleukin-3 Positive Regulation Of Protein Modification Process Regulation Of Glycogen (starch) Synthase Activity Protein Kinase A Catalytic Subunit Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Regulation Of Intracellular Signal Transduction Dynactin Binding Positive Regulation Of Protein Localization To Centrosome Interleukin-18-mediated Signaling Pathway Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Interleukin-13 Production Positive Regulation Of Natural Killer Cell Proliferation Regulation Of Natural Killer Cell Proliferation Positive Regulation Of NK T Cell Proliferation T-helper 1 Type Immune Response Type 2 Immune Response Positive Regulation Of T-helper 2 Cell Differentiation
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