IL18 and IL18BP

Number of citations of the paper that reports this interaction (PMID 11907126)
12

Data Source:
HPRD (in vitro, in vivo)

		IL18	IL18BP
Gene Name		interleukin 18	interleukin 18 binding protein
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Extracellular Vesicular Exosome
	Molecular Function	Cytokine Activity Protein Binding	Interleukin-18 Binding Receptor Antagonist Activity
	Biological Process	MAPK Cascade Angiogenesis Inflammatory Response Immune Response Cell-cell Signaling Positive Regulation Of Gene Expression Natural Killer Cell Activation Regulation Of Cell Adhesion Sleep Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Tissue Remodeling Chemokine Biosynthetic Process T-helper 1 Type Immune Response Type 2 Immune Response Interleukin-2 Biosynthetic Process Interferon-gamma Biosynthetic Process Positive Regulation Of Activated T Cell Proliferation Interleukin-13 Biosynthetic Process Granulocyte Macrophage Colony-stimulating Factor Biosynthetic Process Positive Regulation Of NF-kappaB Import Into Nucleus Negative Regulation Of Myoblast Differentiation Positive Regulation Of Inflammatory Response Positive Regulation Of NK T Cell Proliferation Cellular Response To Organic Cyclic Compound	Response To Lipopolysaccharide T-helper 1 Type Immune Response Cellular Response To Hydrogen Peroxide Cellular Response To Tumor Necrosis Factor Extracellular Negative Regulation Of Signal Transduction
Pathways		Signaling by Interleukins Interleukin-1 processing Cytokine Signaling in Immune system
Drugs
Diseases
GWAS		Protein quantitative trait loci ( 18464913)
Protein-Protein Interactions		8 interactors: CASK CASP1 CASP3 CASP4 IL18BP IL18R1 IL18RAP IL1RL2	2 interactors: IL18 IL37
Entrez ID		3606	10068
HPRD ID		02976	04984
Ensembl ID		ENSG00000150782	ENSG00000137496
Uniprot IDs		Q14116	G3V1C5 O95998
PDB IDs		1J0S 2VXT 3F62 4EEE 4EKX 4HJJ
Enriched GO Terms of Interacting Partners?		Execution Phase Of Apoptosis Immune System Process Immune Response T-helper 1 Type Immune Response Response To Cytokine Regulation Of Inflammatory Response Cellular Response To Organic Substance Positive Regulation Of Cytokine Production Interleukin-18-mediated Signaling Pathway Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Zymogen Activation Response To Organic Substance Regulation Of Cytokine Production Cellular Response To Interleukin-18 Mitochondrial Depolarization Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Response To Cytokine Stimulus Positive Regulation Of Cysteine-type Endopeptidase Activity Response To Tumor Necrosis Factor Positive Regulation Of Endopeptidase Activity Regulation Of Cell Adhesion Response To Interleukin-18 Positive Regulation Of Interleukin-1 Alpha Secretion Positive Regulation Of Peptidase Activity Positive Regulation Of Transport Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Interleukin-1 Alpha Production Pyroptosis Cellular Response To Oxidative Stress Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cell Adhesion Regulation Of Cysteine-type Endopeptidase Activity Glial Cell Apoptotic Process Response To Stress Regulation Of Apoptotic DNA Fragmentation Regulation Of I-kappaB Kinase/NF-kappaB Signaling Protein Processing Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Apoptotic Process Adaptive Immune Response Programmed Cell Death Negative Regulation Of Keratinocyte Proliferation Cell Death Regulation Of T Cell Activation Death Regulation Of Cellular Process Positive Regulation Of Proteolysis Negative Regulation Of Activated T Cell Proliferation Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C	Granulocyte Macrophage Colony-stimulating Factor Biosynthetic Process Chemokine Biosynthetic Process Interleukin-13 Biosynthetic Process Interferon-gamma Biosynthetic Process Positive Regulation Of NK T Cell Proliferation Inflammatory Response Interleukin-2 Biosynthetic Process Positive Regulation Of Natural Killer Cell Proliferation Regulation Of Natural Killer Cell Proliferation Chemokine Metabolic Process Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Interleukin-2 Production Chemokine Production Type 2 Immune Response Positive Regulation Of Interleukin-17 Production Positive Regulation Of Alpha-beta T Cell Proliferation Sleep Interferon-gamma Production Positive Regulation Of NF-kappaB Import Into Nucleus Negative Regulation Of Myoblast Differentiation Positive Regulation Of Activated T Cell Proliferation Cytokine Biosynthetic Process Positive Regulation Of Natural Killer Cell Activation T-helper 1 Type Immune Response Positive Regulation Of Tissue Remodeling Cytokine Metabolic Process Immune Response Regulation Of Activated T Cell Proliferation Defense Response Positive Regulation Of Transcription Factor Import Into Nucleus Lipopolysaccharide-mediated Signaling Pathway Regulation Of NF-kappaB Import Into Nucleus Regulation Of Myoblast Differentiation Negative Regulation Of Muscle Cell Differentiation Positive Regulation Of Interferon-gamma Production Natural Killer Cell Activation Regulation Of Tissue Remodeling Cellular Response To Organic Substance Positive Regulation Of T Cell Proliferation Regulation Of Interferon-gamma Production Regulation Of Transcription Factor Import Into Nucleus Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Inflammatory Response Immune System Process Positive Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Response To Organic Substance Cytokine Production
Tagcloud ?		advance comprehensively doi genotyped haplotype household il1b il4 influences kampala nod2 nominal online persistently publication resistors rstr rstrs slc6a3 snps suggestively tagging tb ticam2 tlr4 tlr6 tollip tuberculin uganda	12r 13r 17r a2m ablim actg2 canx fluorochromes fyb gatm hsp75 immunogenesis irf2 lcp1 lsp maoa peci pleurisy ppid scya14 tcralpha tcrbeta tcrdelta tcrgamma tgfb3 thbd trap1 ttid tubercle
Tagcloud (Difference) ?		advance comprehensively doi genotyped haplotype household il1b il4 influences kampala nod2 nominal online persistently publication resistors rstr rstrs slc6a3 snps suggestively tagging tb ticam2 tlr4 tlr6 tollip tuberculin uganda	12r 13r 17r a2m ablim actg2 canx fluorochromes fyb gatm hsp75 immunogenesis irf2 lcp1 lsp maoa peci pleurisy ppid scya14 tcralpha tcrbeta tcrdelta tcrgamma tgfb3 thbd trap1 ttid tubercle
Tagcloud (Intersection) ?