IL18 and CASP4

Number of citations: 0 (PubMedID 12096920)
Data Source: BioGRID (enzymatic study), HPRD (in vivo)

		IL18	CASP4
Name		interleukin 18	caspase 4
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Cytosol	Extracellular Region Cytoplasm Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Protein-containing Complex Canonical Inflammasome Complex NLRP1 Inflammasome Complex Non-canonical Inflammasome Complex
	Molecular Function	Cytokine Activity Protein Binding Interleukin-18 Receptor Binding Receptor Ligand Activity	Lipopolysaccharide Binding Cysteine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Lipid Binding Hydrolase Activity CARD Domain Binding
	Biological Process	Angiogenesis Inflammatory Response Immune Response Cell Surface Receptor Signaling Pathway Cell-cell Signaling Cell Population Proliferation Positive Regulation Of Gene Expression Positive Regulation Of Macrophage Derived Foam Cell Differentiation Cytokine-mediated Signaling Pathway Natural Killer Cell Activation Regulation Of Cell Adhesion Sleep Positive Regulation Of Chemokine Production Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Tissue Remodeling Interleukin-18-mediated Signaling Pathway T-helper 1 Type Immune Response Type 2 Immune Response Positive Regulation Of Activated T Cell Proliferation Neutrophil Activation Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Cholesterol Homeostasis Positive Regulation Of T-helper 2 Cell Differentiation Negative Regulation Of Myoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Inflammatory Response Defense Response To Gram-positive Bacterium Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of NK T Cell Proliferation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Establishment Of Skin Barrier Triglyceride Homeostasis Cellular Response To Lipopolysaccharide Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Neuroinflammatory Response Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of T-helper 1 Cell Cytokine Production	Immune System Process Proteolysis Apoptotic Process Inflammatory Response Protein Secretion Programmed Cell Death Protein Autoprocessing Interleukin-18-mediated Signaling Pathway Defense Response To Bacterium Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process NLRP3 Inflammasome Complex Assembly Innate Immune Response Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Defense Response To Gram-positive Bacterium Protein Maturation Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Pyroptotic Inflammatory Response Intrinsic Apoptotic Signaling Pathway Pyroptotic Cell Death Non-canonical Inflammasome Complex Assembly Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Cellular Response To Amyloid-beta Positive Regulation Of Interleukin-18-mediated Signaling Pathway
Pathways		Interleukin-1 processing Pyroptosis Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Interleukin-18 signaling Purinergic signaling in leishmaniasis infection CASP4-mediated substrate cleavage CASP5-mediated substrate cleavage	NOD1/2 Signaling Pathway Pyroptosis CASP4 inflammasome assembly Microbial factors inhibit CASP4 activity CASP4-mediated substrate cleavage
Drugs		None	Incadronic acid
GWAS		Blood protein levels in cardiovascular risk ( 28369058 ) Inflammatory biomarkers ( 24182552 ) Interleukin-18 levels ( 27989323 31584380 ) Protein quantitative trait loci ( 18464913 )	Major depressive disorder ( 29317602 )
Novel Interactors		None recorded	1 novel interactors: NOMO1
Interacting Genes		9 interacting genes: ADIRF CASK CASP1 CASP3 CASP4 IL18BP IL18R1 IL18RAP IL1RL2	16 interacting genes: APAF1 APP CASP10 CASP14 CASP3 CASP8 DSP ELF4 IL18 IL1B IL37 MYH9 NOD1 PLA2G4A PSEN1 SERPINB9
Entrez ID		3606	837
HPRD ID		02976	04047
Ensembl ID		ENSG00000150782	ENSG00000196954
Uniprot IDs		Q14116	P49662
PDB IDs		1J0S 2VXT 3F62 3WO2 3WO3 3WO4 4EEE 4EKX 4HJJ 4R6U 4XFS 4XFT 4XFU 7AL7 8J6K 8SPB 8SV1 8URV	6KMZ 6NRY 7WR0 7WR1 7WR4 7WR5 7WR6 8J6K 8SPB
GO Terms Enriched among Interactors		Interleukin-18-mediated Signaling Pathway Cytokine-mediated Signaling Pathway NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating Inflammatory Response Interleukin-18 Receptor Complex Interleukin-18 Receptor Activity Interleukin-18 Binding Pyroptotic Inflammatory Response NLRP1 Inflammasome Complex Interleukin-1 Receptor Activity Cysteine-type Endopeptidase Activity Immune System Process Cellular Response To Chemical Stress Defense Response Response To Hydrogen Peroxide Canonical Inflammasome Complex Regulation Of Defense Response CARD Domain Binding Pyroptotic Cell Death Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Cysteine-type Peptidase Activity Protein Poly-ADP-ribosylation Regulation Of Inflammatory Response Hydrolase Activity Protein Autoprocessing Positive Regulation Of Defense Response Response To Reactive Oxygen Species Positive Regulation Of Inflammatory Response Interleukin-1-mediated Signaling Pathway Protein Processing Response To Cytokine Response To Peptide Cell Surface Receptor Signaling Pathway Immune Response Response To Stress Response To External Biotic Stimulus Cellular Response To Osmotic Stress Signaling Receptor Activity Adaptive Immune Response Response To Lipopolysaccharide Protein Maturation Positive Regulation Of Cytokine-mediated Signaling Pathway Regulation Of Cytokine Production Response To Molecule Of Bacterial Origin Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Response To Cytokine Stimulus Positive Regulation Of Neuron Apoptotic Process Non-canonical Inflammasome Complex Cellular Response To Interleukin-18 Cellular Response To Hydrogen Peroxide	Positive Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Process Regulation Of Defense Response Positive Regulation Of Neuron Apoptotic Process Regulation Of Cytokine Production Cell Death Programmed Cell Death Regulation Of Inflammatory Response Regulation Of Neuron Apoptotic Process Regulation Of Apoptotic Process Immune System Process Regulation Of Programmed Cell Death Regulation Of Interleukin-6 Production Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Cysteine-type Endopeptidase Activity Positive Regulation Of Inflammatory Response Regulation Of Tumor Necrosis Factor Production Astrocyte Activation Positive Regulation Of T-helper 1 Type Immune Response Apoptotic Process Regulation Of Proteolysis Positive Regulation Of Proteolysis Regulation Of Immune Response Execution Phase Of Apoptosis Regulation Of Interleukin-1 Beta Production Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Defense Response Regulation Of Interleukin-1 Production Defense Response To Gram-positive Bacterium Astrocyte Activation Involved In Immune Response Death Effector Domain Binding Regulation Of Immune System Process Positive Regulation Of Cytokine Production Positive Regulation Of Protein Metabolic Process Cysteine-type Peptidase Activity Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Response To Lipopolysaccharide Inflammatory Response Apoptotic Signaling Pathway Response To Anesthetic Response To Molecule Of Bacterial Origin Ripoptosome CD95 Death-inducing Signaling Complex Regulation Of Multicellular Organismal Process Death-inducing Signaling Complex Natural Killer Cell Activation Positive Regulation Of T-helper 1 Cell Cytokine Production Cell Activation Positive Regulation Of Immune System Process