EXOSC2 and ST6GALNAC1

Number of citations of the paper that reports this interaction (PMID 15231747)
44

Data Source:
BioGRID (two hybrid)

		EXOSC2	ST6GALNAC1
Gene Name		exosome component 2	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleolus Cytoplasm Cytosol	Golgi Membrane Integral Component Of Membrane
	Molecular Function	3'-5'-exoribonuclease Activity Exoribonuclease Activity Protein Binding 7S RNA Binding	Alpha-N-acetylgalactosaminide Alpha-2,6-sialyltransferase Activity Sialyltransferase Activity
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RRNA Processing Gene Expression Positive Regulation Of Cell Growth Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' U4 SnRNA 3'-end Processing Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay CUT Catabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process Nuclear Polyadenylation-dependent TRNA Catabolic Process Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription Polyadenylation-dependent SnoRNA 3'-end Processing	Protein Glycosylation Dolichol-linked Oligosaccharide Biosynthetic Process Oligosaccharide Biosynthetic Process Protein N-linked Glycosylation Via Asparagine Post-translational Protein Modification Cellular Protein Metabolic Process Sialylation
Pathways		Regulation of mRNA stability by proteins that bind AU-rich elements KSRP destabilizes mRNA mRNA decay by 3' to 5' exoribonuclease ATF4 activates genes Tristetraprolin (TTP) destabilizes mRNA PERK regulates gene expression Unfolded Protein Response (UPR) Deadenylation-dependent mRNA decay Butyrate Response Factor 1 (BRF1) destabilizes mRNA	Diseases of glycosylation Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective ALG1 causes ALG1-CDG (CDG-1k) Defective MOGS causes MOGS-CDG (CDG-2b) Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 Defective ALG11 causes ALG11-CDG (CDG-1p) Defective ALG2 causes ALG2-CDG (CDG-1i) Post-translational protein modification Defective ALG3 causes ALG3-CDG (CDG-1d) Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Synthesis of substrates in N-glycan biosythesis Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective ALG6 causes ALG6-CDG (CDG-1c) Defective RFT1 causes RFT1-CDG (CDG-1n) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Sialic acid metabolism Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Diseases associated with N-glycosylation of proteins
Drugs
Diseases
GWAS
Protein-Protein Interactions		16 interactors: DIS3 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 GALNT13 KHSRP MPP6 MRPL48 RNF8 SKIV2L2 ST6GALNAC1 UPF1 ZNF408	1 interactors: EXOSC2
Entrez ID		23404	55808
HPRD ID		03758	15340
Ensembl ID		ENSG00000130713	ENSG00000070526
Uniprot IDs		B3KQW2 Q13868	Q9NSC7 Q9NXQ7
PDB IDs		2NN6
Enriched GO Terms of Interacting Partners?		Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic RRNA Processing RRNA Metabolic Process MRNA Catabolic Process RNA Catabolic Process Ribosome Biogenesis Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process Ribonucleoprotein Complex Biogenesis MRNA Metabolic Process Aromatic Compound Catabolic Process NcRNA Metabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Cellular Macromolecule Catabolic Process RNA Phosphodiester Bond Hydrolysis DNA Deamination Catabolic Process RNA Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Maturation Of 5.8S RRNA Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Metabolic Process Nucleic Acid Phosphodiester Bond Hydrolysis Nitrogen Compound Metabolic Process Nuclear MRNA Surveillance RNA Surveillance Histone MRNA Catabolic Process DNA Modification RRNA Catabolic Process Histone MRNA Metabolic Process Isotype Switching Metabolic Process Somatic Recombination Of Immunoglobulin Gene Segments Somatic Diversification Of Immunoglobulins Immunoglobulin Production Involved In Immunoglobulin Mediated Immune Response B Cell Activation Involved In Immune Response DNA Metabolic Process Immunoglobulin Production Histone H2A K63-linked Ubiquitination Nuclear Polyadenylation-dependent RRNA Catabolic Process CUT Catabolic Process Positive Regulation Of Cell Growth MRNA Transport RNA Transport RNA Localization Leukocyte Activation Involved In Immune Response	Nuclear Polyadenylation-dependent TRNA Catabolic Process U4 SnRNA 3'-end Processing Polyadenylation-dependent SnoRNA 3'-end Processing Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' TRNA Catabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process CUT Catabolic Process Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) SnoRNA Metabolic Process Nuclear MRNA Surveillance RRNA 3'-end Processing RNA Surveillance Intracellular MRNA Localization RRNA Catabolic Process Maturation Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Maturation Of 5.8S RRNA Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic RNA Phosphodiester Bond Hydrolysis, Exonucleolytic SnRNA Processing SnRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay RNA 3'-end Processing RNA Phosphodiester Bond Hydrolysis Positive Regulation Of Cell Growth RRNA Processing RRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process RNA Localization MRNA Catabolic Process RNA Catabolic Process Ribosome Biogenesis Positive Regulation Of Growth TRNA Metabolic Process Nucleic Acid Phosphodiester Bond Hydrolysis Ribonucleoprotein Complex Biogenesis Regulation Of Cell Growth Aromatic Compound Catabolic Process NcRNA Metabolic Process MRNA Metabolic Process RNA Processing Regulation Of Growth Cellular Macromolecule Catabolic Process
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