EXOSC2 and EXOSC9

Number of citations of the paper that reports this interaction (PMID 11719186)
268

Data Source:
BioGRID (biochemical)
HPRD (two hybrid, in vivo)

		EXOSC2	EXOSC9
Gene Name		exosome component 2	exosome component 9
Image
Gene Ontology Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleolus Cytoplasm Cytosol	Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Nuclear Chromosome Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Intermediate Filament Cytoskeleton Extracellular Vesicular Exosome
	Molecular Function	3'-5'-exoribonuclease Activity Exoribonuclease Activity Protein Binding 7S RNA Binding	3'-5'-exoribonuclease Activity RNA Binding Exoribonuclease Activity Protein Binding AU-rich Element Binding Poly(A) RNA Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RRNA Processing Gene Expression Positive Regulation Of Cell Growth Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' U4 SnRNA 3'-end Processing Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay CUT Catabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process Nuclear Polyadenylation-dependent TRNA Catabolic Process Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription Polyadenylation-dependent SnoRNA 3'-end Processing	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process RRNA Processing Immune Response Gene Expression Positive Regulation Of Cell Growth Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear MRNA Surveillance Nuclear Polyadenylation-dependent RRNA Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Pathways		Regulation of mRNA stability by proteins that bind AU-rich elements KSRP destabilizes mRNA mRNA decay by 3' to 5' exoribonuclease ATF4 activates genes Tristetraprolin (TTP) destabilizes mRNA PERK regulates gene expression Unfolded Protein Response (UPR) Deadenylation-dependent mRNA decay Butyrate Response Factor 1 (BRF1) destabilizes mRNA	Regulation of mRNA stability by proteins that bind AU-rich elements KSRP destabilizes mRNA mRNA decay by 3' to 5' exoribonuclease ATF4 activates genes Tristetraprolin (TTP) destabilizes mRNA PERK regulates gene expression Unfolded Protein Response (UPR) Deadenylation-dependent mRNA decay Butyrate Response Factor 1 (BRF1) destabilizes mRNA
Drugs
Diseases
GWAS
Protein-Protein Interactions		16 interactors: DIS3 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 GALNT13 KHSRP MPP6 MRPL48 RNF8 SKIV2L2 ST6GALNAC1 UPF1 ZNF408	17 interactors: CHMP4B CSNK2A1 DDX39A DDX39B DIS3 EXOSC1 EXOSC2 EXOSC3 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 MPP6 SKIV2L2 UBE2I ZDHHC17
Entrez ID		23404	5393
HPRD ID		03758	07315
Ensembl ID		ENSG00000130713	ENSG00000123737
Uniprot IDs		B3KQW2 Q13868	B4DXG8 Q06265
PDB IDs		2NN6	2NN6
Enriched GO Terms of Interacting Partners?		Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic RRNA Processing RRNA Metabolic Process MRNA Catabolic Process RNA Catabolic Process Ribosome Biogenesis Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process Ribonucleoprotein Complex Biogenesis MRNA Metabolic Process Aromatic Compound Catabolic Process NcRNA Metabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Cellular Macromolecule Catabolic Process RNA Phosphodiester Bond Hydrolysis DNA Deamination Catabolic Process RNA Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Maturation Of 5.8S RRNA Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Metabolic Process Nucleic Acid Phosphodiester Bond Hydrolysis Nitrogen Compound Metabolic Process Nuclear MRNA Surveillance RNA Surveillance Histone MRNA Catabolic Process DNA Modification RRNA Catabolic Process Histone MRNA Metabolic Process Isotype Switching Metabolic Process Somatic Recombination Of Immunoglobulin Gene Segments Somatic Diversification Of Immunoglobulins Immunoglobulin Production Involved In Immunoglobulin Mediated Immune Response B Cell Activation Involved In Immune Response DNA Metabolic Process Immunoglobulin Production Histone H2A K63-linked Ubiquitination Nuclear Polyadenylation-dependent RRNA Catabolic Process CUT Catabolic Process Positive Regulation Of Cell Growth MRNA Transport RNA Transport RNA Localization Leukocyte Activation Involved In Immune Response	Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic RRNA Processing RRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Ribosome Biogenesis Ribonucleoprotein Complex Biogenesis MRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Catabolic Process NcRNA Metabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Maturation Of 5.8S RRNA Cellular Macromolecule Catabolic Process Aromatic Compound Catabolic Process DNA Deamination RNA Phosphodiester Bond Hydrolysis RNA Metabolic Process CUT Catabolic Process Catabolic Process Nuclear MRNA Surveillance Gene Expression RNA Surveillance Nucleobase-containing Compound Metabolic Process Nucleic Acid Phosphodiester Bond Hydrolysis RRNA Catabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process DNA Modification Nitrogen Compound Metabolic Process Nuclear Polyadenylation-dependent TRNA Catabolic Process Polyadenylation-dependent SnoRNA 3'-end Processing Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription U4 SnRNA 3'-end Processing Cellular Metabolic Process TRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Nuclear Polyadenylation-dependent RRNA Catabolic Process RNA Localization SnoRNA Metabolic Process RRNA 3'-end Processing Intracellular MRNA Localization Maturation Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RNA Processing Positive Regulation Of Cell Growth Metabolic Process Isotype Switching
Tagcloud ?			balance compartment degradation differentiation done enriched epidermal exosome grhl3 loss maintain maintaining maintains maintenance mammalian necessary pm premature prevent prevents progenitor proliferative promotes regulating renewal reside retain transcript understood
Tagcloud (Difference) ?			balance compartment degradation differentiation done enriched epidermal exosome grhl3 loss maintain maintaining maintains maintenance mammalian necessary pm premature prevent prevents progenitor proliferative promotes regulating renewal reside retain transcript understood
Tagcloud (Intersection) ?