EXOSC2 and EXOSC4

Number of citations of the paper that reports this interaction (PMID 11719186)
268

Data Source:
HPRD (in vitro, two hybrid, in vivo)

		EXOSC2	EXOSC4
Gene Name		exosome component 2	exosome component 4
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Gene Ontology Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleolus Cytoplasm Cytosol	Exosome (RNase Complex) Nucleus Nucleolus Cytoplasm Cytosol Transcriptionally Active Chromatin
	Molecular Function	3'-5'-exoribonuclease Activity Exoribonuclease Activity Protein Binding 7S RNA Binding	3'-5'-exoribonuclease Activity Exoribonuclease Activity Protein Binding AU-rich Element Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RRNA Processing Gene Expression Positive Regulation Of Cell Growth Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' U4 SnRNA 3'-end Processing Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay CUT Catabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process Nuclear Polyadenylation-dependent TRNA Catabolic Process Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription Polyadenylation-dependent SnoRNA 3'-end Processing	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Maturation Of 5.8S RRNA Nuclear-transcribed MRNA Catabolic Process RRNA Processing Gene Expression Positive Regulation Of Cell Growth Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay DNA Deamination Defense Response To Virus Nuclear MRNA Surveillance Histone MRNA Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Pathways		Regulation of mRNA stability by proteins that bind AU-rich elements KSRP destabilizes mRNA mRNA decay by 3' to 5' exoribonuclease ATF4 activates genes Tristetraprolin (TTP) destabilizes mRNA PERK regulates gene expression Unfolded Protein Response (UPR) Deadenylation-dependent mRNA decay Butyrate Response Factor 1 (BRF1) destabilizes mRNA	Regulation of mRNA stability by proteins that bind AU-rich elements KSRP destabilizes mRNA mRNA decay by 3' to 5' exoribonuclease ATF4 activates genes Tristetraprolin (TTP) destabilizes mRNA PERK regulates gene expression Unfolded Protein Response (UPR) Deadenylation-dependent mRNA decay Butyrate Response Factor 1 (BRF1) destabilizes mRNA
Drugs
Diseases
GWAS
Protein-Protein Interactions		16 interactors: DIS3 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 GALNT13 KHSRP MPP6 MRPL48 RNF8 SKIV2L2 ST6GALNAC1 UPF1 ZNF408	27 interactors: AKR1A1 DIS3 DXO EEF1A1 EXOSC1 EXOSC10 EXOSC2 EXOSC3 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FAHD1 GADD45GIP1 GTF2IRD1 HNRNPD LRRC8D MPP6 MPZL1 NEK1 SKIV2L SKIV2L2 SMPD4 TSEN15 UPF1 UPF2 UPF3B
Entrez ID		23404	54512
HPRD ID		03758	16221
Ensembl ID		ENSG00000130713	ENSG00000178896
Uniprot IDs		B3KQW2 Q13868	Q9NPD3
PDB IDs		2NN6	2NN6
Enriched GO Terms of Interacting Partners?		Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic RRNA Processing RRNA Metabolic Process MRNA Catabolic Process RNA Catabolic Process Ribosome Biogenesis Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process Ribonucleoprotein Complex Biogenesis MRNA Metabolic Process Aromatic Compound Catabolic Process NcRNA Metabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Cellular Macromolecule Catabolic Process RNA Phosphodiester Bond Hydrolysis DNA Deamination Catabolic Process RNA Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Maturation Of 5.8S RRNA Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Metabolic Process Nucleic Acid Phosphodiester Bond Hydrolysis Nitrogen Compound Metabolic Process Nuclear MRNA Surveillance RNA Surveillance Histone MRNA Catabolic Process DNA Modification RRNA Catabolic Process Histone MRNA Metabolic Process Isotype Switching Metabolic Process Somatic Recombination Of Immunoglobulin Gene Segments Somatic Diversification Of Immunoglobulins Immunoglobulin Production Involved In Immunoglobulin Mediated Immune Response B Cell Activation Involved In Immune Response DNA Metabolic Process Immunoglobulin Production Histone H2A K63-linked Ubiquitination Nuclear Polyadenylation-dependent RRNA Catabolic Process CUT Catabolic Process Positive Regulation Of Cell Growth MRNA Transport RNA Transport RNA Localization Leukocyte Activation Involved In Immune Response	RNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process MRNA Metabolic Process RRNA Processing Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay RRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Aromatic Compound Catabolic Process Ribosome Biogenesis Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear MRNA Surveillance Ribonucleoprotein Complex Biogenesis NcRNA Metabolic Process Cellular Macromolecule Catabolic Process RNA Surveillance RNA Phosphodiester Bond Hydrolysis, Exonucleolytic RRNA Catabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process CUT Catabolic Process Catabolic Process Maturation Of 5.8S RRNA RNA Metabolic Process RNA Phosphodiester Bond Hydrolysis Gene Expression Nucleic Acid Phosphodiester Bond Hydrolysis Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process RNA Localization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Intracellular MRNA Localization Nuclear Polyadenylation-dependent TRNA Catabolic Process Polyadenylation-dependent SnoRNA 3'-end Processing Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription U4 SnRNA 3'-end Processing RNA Processing TRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Cellular Metabolic Process Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) SnoRNA Metabolic Process RRNA 3'-end Processing DNA Deamination Histone MRNA Catabolic Process Dosage Compensation By Inactivation Of X Chromosome MRNA Export From Nucleus Metabolic Process
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