EXOSC2 and ADAMTS13

		EXOSC2	ADAMTS13
Description		exosome component 2	ADAM metallopeptidase with thrombospondin type 1 motif 13
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GO Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Nucleolar Exosome (RNase Complex)	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Cell Surface Extracellular Matrix
	Molecular Function	3'-5'-RNA Exonuclease Activity RNA Binding RNA Exonuclease Activity Protein Binding 7S RNA Binding	Endopeptidase Activity Metalloendopeptidase Activity Integrin Binding Calcium Ion Binding Protein Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Nuclear-transcribed MRNA Catabolic Process RRNA Processing RNA Processing RNA Catabolic Process Positive Regulation Of Cell Growth U4 SnRNA 3'-end Processing CUT Catabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process TRAMP-dependent TRNA Surveillance Pathway Poly(A)-dependent SnoRNA 3'-end Processing	Proteolysis Cell-matrix Adhesion Integrin-mediated Signaling Pathway Blood Coagulation Hemostasis Glycoprotein Metabolic Process Response To Toxic Substance Response To Amine Protein Processing Protein Catabolic Process Platelet Activation Extracellular Matrix Organization Response To Type II Interferon Response To Tumor Necrosis Factor Response To Potassium Ion Peptide Catabolic Process Response To Interleukin-4 Cellular Response To Lipopolysaccharide Cellular Response To Type II Interferon Cellular Response To Interleukin-4 Cellular Response To Tumor Necrosis Factor
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay	Defective B3GALTL causes PpS O-glycosylation of TSR domain-containing proteins Platelet Adhesion to exposed collagen Enhanced cleavage of VWF variant by ADAMTS13 Defective VWF cleavage by ADAMTS13 variant
Drugs
Diseases			Thrombotic thrombocytopenic purpura; Moschcowitz disease; Schulman-Upshaw syndrome
GWAS			Activated partial thromboplastin time ( 22703881) ADAMTS13 activity ( 25934476) ADAMTS13 levels ( 29296746) Circulating fibroblast growth factor 23 levels ( 30217807) Coagulation factor levels ( 23267103) Cobalt levels ( 26025379) Gut microbiota (functional units) ( 27694959) Liver enzyme levels ( 18940312) Lymphocyte percentage of white cells ( 32888494) Malaria ( 31844061) Pancreatic cancer ( 25086665) vWF levels in ischaemic stroke and hyperhomocysteinaemia ( 28495826)
Interacting Genes		18 interacting genes: DIS3 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 GALNT13 KHSRP MRPL48 MTREX PALS2 PTEN RNF8 SBK3 ST6GALNAC1 UPF1 ZNF408	1 interacting genes: VWF
Entrez ID		23404	11093
HPRD ID		03758	04994
Ensembl ID		ENSG00000130713	ENSG00000160323
Uniprot IDs		B3KQW2 Q13868	Q76LX8
PDB IDs		2NN6 6D6Q 6D6R 6H25 9G8M 9G8N 9G8O 9G8P	3GHM 3GHN 3VN4 6QIG 7B01
Enriched GO Terms of Interacting Partners?		Exosome (RNase Complex) Nuclear Exosome (RNase Complex) Nuclear MRNA Surveillance Cytoplasmic Exosome (RNase Complex) RRNA Catabolic Process U4 SnRNA 3'-end Processing Nucleolar Exosome (RNase Complex) RNA Exonuclease Activity Exoribonuclease Complex Nuclear RNA Surveillance RNA Surveillance SnRNA 3'-end Processing SnRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process SnRNA Processing RNA Catabolic Process MRNA Catabolic Process MRNA 3'-UTR AU-rich Region Binding 3'-5'-RNA Exonuclease Activity RRNA Processing Nucleobase-containing Compound Catabolic Process U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing RNA 3'-end Processing RRNA Metabolic Process MRNA Metabolic Process Macromolecule Catabolic Process Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance TRAMP-dependent TRNA Surveillance Pathway Nuclear Polyadenylation-dependent RRNA Catabolic Process Poly(A)-dependent SnoRNA 3'-end Processing RRNA 3'-end Processing TRNA Decay DNA Deamination Sno(s)RNA Metabolic Process RNA Processing DNA Modification Nucleolus RNA Binding Catabolic Process RNA Metabolic Process Negative Regulation Of Gene Expression Macromolecule Metabolic Process Nucleic Acid Metabolic Process Histone MRNA Catabolic Process 3'-UTR-mediated MRNA Destabilization Maturation Of 5.8S RRNA Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process	Immunoglobulin Binding Weibel-Palade Body Set1C/COMPASS Complex NSL Complex Histone H3Q5ser Reader Activity MLL3/4 Complex Histone H3K4 Methyltransferase Activity ATAC Complex MLL1/2 Complex Histone H3K4me1 Reader Activity Cytoplasmic Exosome (RNase Complex) Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) 7S RNA Binding TRAMP-dependent TRNA Surveillance Pathway TRNA Surveillance TRNA Decay RRNA 3'-end Processing Nucleolar Exosome (RNase Complex) Nuclear Polyadenylation-dependent RRNA Catabolic Process RNA Exonuclease Activity U4 SnRNA 3'-end Processing CUT Catabolic Process Poly(A)-dependent SnoRNA 3'-end Processing Sno(s)RNA Metabolic Process Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Platelet Alpha Granule SnRNA 3'-end Processing Positive Regulation Of Gluconeogenesis Histone Acetyltransferase Complex Histone Methyltransferase Complex 3'-5'-RNA Exonuclease Activity MLL1 Complex SnRNA Processing Nuclear RNA Surveillance RNA Surveillance Positive Regulation Of Glucose Metabolic Process Positive Regulation Of Gene Expression, Epigenetic Gluconeogenesis Regulation Of Gluconeogenesis Transcription Initiation-coupled Chromatin Remodeling SnRNA Metabolic Process Hexose Biosynthetic Process Platelet Alpha Granule Lumen Collagen Binding Platelet Activation
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