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EXOSC2
Gene Name
exosome component 2
Image
Gene Ontology Annotations
Cellular Component
Nuclear Exosome (RNase Complex)
Cytoplasmic Exosome (RNase Complex)
Exosome (RNase Complex)
Nucleus
Nucleolus
Cytoplasm
Cytosol
Molecular Function
3'-5'-exoribonuclease Activity
Exoribonuclease Activity
Protein Binding
7S RNA Binding
Biological Process
Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA)
RRNA Processing
Gene Expression
Positive Regulation Of Cell Growth
Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5'
U4 SnRNA 3'-end Processing
Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
CUT Catabolic Process
Nuclear Polyadenylation-dependent RRNA Catabolic Process
Nuclear Polyadenylation-dependent TRNA Catabolic Process
Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription
Polyadenylation-dependent SnoRNA 3'-end Processing
Pathways
Regulation of mRNA stability by proteins that bind AU-rich elements
KSRP destabilizes mRNA
mRNA decay by 3' to 5' exoribonuclease
ATF4 activates genes
Tristetraprolin (TTP) destabilizes mRNA
PERK regulates gene expression
Unfolded Protein Response (UPR)
Deadenylation-dependent mRNA decay
Butyrate Response Factor 1 (BRF1) destabilizes mRNA
Drugs
Diseases
GWAS
Protein-protein Interactions
16 interactors:
DIS3
EXOSC4
EXOSC5
EXOSC6
EXOSC7
EXOSC8
EXOSC9
GALNT13
KHSRP
MPP6
MRPL48
RNF8
SKIV2L2
ST6GALNAC1
UPF1
ZNF408
Entrez ID
23404
HPRD ID
03758
Ensembl ID
ENSG00000130713
Uniprot IDs
B3KQW2
Q13868
PDB IDs
2NN6
Enriched GO Terms of Interacting Partners
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Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic
RRNA Processing
RRNA Metabolic Process
MRNA Catabolic Process
RNA Catabolic Process
Ribosome Biogenesis
Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
Nuclear-transcribed MRNA Catabolic Process
Ribonucleoprotein Complex Biogenesis
MRNA Metabolic Process
Aromatic Compound Catabolic Process
NcRNA Metabolic Process
RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Cellular Macromolecule Catabolic Process
RNA Phosphodiester Bond Hydrolysis
DNA Deamination
Catabolic Process
RNA Metabolic Process
Gene Expression
Nucleobase-containing Compound Metabolic Process
Maturation Of 5.8S RRNA
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Cellular Metabolic Process
Nucleic Acid Phosphodiester Bond Hydrolysis
Nitrogen Compound Metabolic Process
Nuclear MRNA Surveillance
RNA Surveillance
Histone MRNA Catabolic Process
DNA Modification
RRNA Catabolic Process
Histone MRNA Metabolic Process
Isotype Switching
Metabolic Process
Somatic Recombination Of Immunoglobulin Gene Segments
Somatic Diversification Of Immunoglobulins
Immunoglobulin Production Involved In Immunoglobulin Mediated Immune Response
B Cell Activation Involved In Immune Response
DNA Metabolic Process
Immunoglobulin Production
Histone H2A K63-linked Ubiquitination
Nuclear Polyadenylation-dependent RRNA Catabolic Process
CUT Catabolic Process
Positive Regulation Of Cell Growth
MRNA Transport
RNA Transport
RNA Localization
Leukocyte Activation Involved In Immune Response
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