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EXOSC2 and UPF1
Number of citations of the paper that reports this interaction (PMID
14527413
)
102
Data Source:
BioGRID
(affinity chromatography technology, affinity chromatography technology)
HPRD
(in vivo)
EXOSC2
UPF1
Gene Name
exosome component 2
UPF1 regulator of nonsense transcripts homolog (yeast)
Image
Gene Ontology Annotations
Cellular Component
Nuclear Exosome (RNase Complex)
Cytoplasmic Exosome (RNase Complex)
Exosome (RNase Complex)
Nucleus
Nucleolus
Cytoplasm
Cytosol
Chromatin
Cytoplasmic MRNA Processing Body
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Exon-exon Junction Complex
Supraspliceosomal Complex
Molecular Function
3'-5'-exoribonuclease Activity
Exoribonuclease Activity
Protein Binding
7S RNA Binding
DNA Binding
Chromatin Binding
RNA Binding
ATP-dependent RNA Helicase Activity
Helicase Activity
Protein Binding
ATP Binding
Zinc Ion Binding
Poly(A) RNA Binding
Biological Process
Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA)
RRNA Processing
Gene Expression
Positive Regulation Of Cell Growth
Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5'
U4 SnRNA 3'-end Processing
Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
CUT Catabolic Process
Nuclear Polyadenylation-dependent RRNA Catabolic Process
Nuclear Polyadenylation-dependent TRNA Catabolic Process
Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription
Polyadenylation-dependent SnoRNA 3'-end Processing
Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
Nuclear-transcribed MRNA Catabolic Process
DNA Replication
DNA Repair
MRNA Export From Nucleus
Regulation Of Translational Termination
Dosage Compensation By Inactivation Of X Chromosome
Gene Expression
Histone MRNA Catabolic Process
Pathways
Regulation of mRNA stability by proteins that bind AU-rich elements
KSRP destabilizes mRNA
mRNA decay by 3' to 5' exoribonuclease
ATF4 activates genes
Tristetraprolin (TTP) destabilizes mRNA
PERK regulates gene expression
Unfolded Protein Response (UPR)
Deadenylation-dependent mRNA decay
Butyrate Response Factor 1 (BRF1) destabilizes mRNA
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Nonsense-Mediated Decay (NMD)
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS
Protein-Protein Interactions
16 interactors:
DIS3
EXOSC4
EXOSC5
EXOSC6
EXOSC7
EXOSC8
EXOSC9
GALNT13
KHSRP
MPP6
MRPL48
RNF8
SKIV2L2
ST6GALNAC1
UPF1
ZNF408
31 interactors:
ABHD16A
ACSS2
ATR
CSNK2B
DCP1A
DCP2
DXO
EIF3A
EIF3B
EIF4A3
EXOSC2
EXOSC4
GNPTG
GSPT2
HIRA
LSM8
NADSYN1
NDRG1
NDUFB10
PLEKHA5
PLEKHB2
POLR2A
RHOXF2
RPRD2
SMG1
SMG5
STAU1
UPF2
UPF3A
UPF3B
XRN1
Entrez ID
23404
5976
HPRD ID
03758
03254
Ensembl ID
ENSG00000130713
ENSG00000005007
Uniprot IDs
B3KQW2
Q13868
Q92900
PDB IDs
2NN6
2GJK
2GK6
2GK7
2IYK
2WJV
2WJY
2XZO
2XZP
Enriched GO Terms of Interacting Partners
?
Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic
RRNA Processing
RRNA Metabolic Process
MRNA Catabolic Process
RNA Catabolic Process
Ribosome Biogenesis
Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
Nuclear-transcribed MRNA Catabolic Process
Ribonucleoprotein Complex Biogenesis
MRNA Metabolic Process
Aromatic Compound Catabolic Process
NcRNA Metabolic Process
RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Cellular Macromolecule Catabolic Process
RNA Phosphodiester Bond Hydrolysis
DNA Deamination
Catabolic Process
RNA Metabolic Process
Gene Expression
Nucleobase-containing Compound Metabolic Process
Maturation Of 5.8S RRNA
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Cellular Metabolic Process
Nucleic Acid Phosphodiester Bond Hydrolysis
Nitrogen Compound Metabolic Process
Nuclear MRNA Surveillance
RNA Surveillance
Histone MRNA Catabolic Process
DNA Modification
RRNA Catabolic Process
Histone MRNA Metabolic Process
Isotype Switching
Metabolic Process
Somatic Recombination Of Immunoglobulin Gene Segments
Somatic Diversification Of Immunoglobulins
Immunoglobulin Production Involved In Immunoglobulin Mediated Immune Response
B Cell Activation Involved In Immune Response
DNA Metabolic Process
Immunoglobulin Production
Histone H2A K63-linked Ubiquitination
Nuclear Polyadenylation-dependent RRNA Catabolic Process
CUT Catabolic Process
Positive Regulation Of Cell Growth
MRNA Transport
RNA Transport
RNA Localization
Leukocyte Activation Involved In Immune Response
Nuclear-transcribed MRNA Catabolic Process
MRNA Catabolic Process
RNA Catabolic Process
MRNA Metabolic Process
Aromatic Compound Catabolic Process
Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
Cellular Macromolecule Catabolic Process
RNA Localization
Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
Nuclear MRNA Surveillance
Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic
RNA Surveillance
MRNA Transport
RNA Transport
Gene Expression
Catabolic Process
Nucleobase-containing Compound Metabolic Process
RNA Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Histone MRNA Catabolic Process
Cellular Nitrogen Compound Metabolic Process
Nuclear Export
Nucleocytoplasmic Transport
Nuclear Transport
Nitrogen Compound Metabolic Process
MRNA Export From Nucleus
RNA Export From Nucleus
Histone MRNA Metabolic Process
RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Cellular Metabolic Process
Cytoplasmic Transport
Posttranscriptional Regulation Of Gene Expression
Regulation Of Translation
RRNA Metabolic Process
Nucleic Acid Phosphodiester Bond Hydrolysis
Ribonucleoprotein Complex Biogenesis
Ribosome Biogenesis
Intracellular MRNA Localization
RRNA Catabolic Process
Positive Regulation Of Translation
MRNA Splicing, Via Spliceosome
RNA Splicing, Via Transesterification Reactions
Maturation Of 5.8S RRNA
NcRNA Metabolic Process
RNA 3'-end Processing
RNA Phosphodiester Bond Hydrolysis
Formation Of Translation Preinitiation Complex
RRNA Processing
Tagcloud
?
aav9
adeno
als
amyotrophic
cord
decay
empty
exerts
forelimb
green
helps
implicate
mycupf1
nmd
nonsense
otherwise
paralysis
quadriplegic
recapitulate
reproducible
respective
spinal
tdp
titrated
transactive
twofold
upframeshift
validate
vector
Tagcloud (Difference)
?
aav9
adeno
als
amyotrophic
cord
decay
empty
exerts
forelimb
green
helps
implicate
mycupf1
nmd
nonsense
otherwise
paralysis
quadriplegic
recapitulate
reproducible
respective
spinal
tdp
titrated
transactive
twofold
upframeshift
validate
vector
Tagcloud (Intersection)
?