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EXOSC2 and MRPL48
Number of citations of the paper that reports this interaction (PubMedID
15231747
)
47
Data Source:
BioGRID
(two hybrid)
EXOSC2
MRPL48
Description
exosome component 2
mitochondrial ribosomal protein L48
Image
GO Annotations
Cellular Component
Nuclear Exosome (RNase Complex)
Cytoplasmic Exosome (RNase Complex)
Exosome (RNase Complex)
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Nucleolar Exosome (RNase Complex)
Mitochondrion
Mitochondrial Inner Membrane
Mitochondrial Ribosome
Mitochondrial Large Ribosomal Subunit
Ribosome
Ribonucleoprotein Complex
Molecular Function
3'-5'-RNA Exonuclease Activity
RNA Binding
RNA Exonuclease Activity
Protein Binding
7S RNA Binding
Protein Binding
Biological Process
Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA)
Nuclear-transcribed MRNA Catabolic Process
RRNA Processing
RNA Processing
RNA Catabolic Process
Positive Regulation Of Cell Growth
U4 SnRNA 3'-end Processing
CUT Catabolic Process
Nuclear Polyadenylation-dependent RRNA Catabolic Process
TRAMP-dependent TRNA Surveillance Pathway
Poly(A)-dependent SnoRNA 3'-end Processing
Mitochondrial Translation
Pathways
ATF4 activates genes in response to endoplasmic reticulum stress
mRNA decay by 3' to 5' exoribonuclease
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
KSRP (KHSRP) binds and destabilizes mRNA
Major pathway of rRNA processing in the nucleolus and cytosol
Nuclear RNA decay
Mitochondrial translation initiation
Mitochondrial translation elongation
Mitochondrial translation elongation
Mitochondrial translation termination
Mitochondrial ribosome-associated quality control
Drugs
Diseases
GWAS
Dimensional psychopathology (Cognitive) (
29496196
)
Major depressive disorder (
29317602
)
Obesity-related traits (
23251661
)
Interacting Genes
18 interacting genes:
DIS3
EXOSC4
EXOSC5
EXOSC6
EXOSC7
EXOSC8
EXOSC9
GALNT13
KHSRP
MRPL48
MTREX
PALS2
PTEN
RNF8
SBK3
ST6GALNAC1
UPF1
ZNF408
4 interacting genes:
APP
EXOSC2
LSM8
OXA1L
Entrez ID
23404
51642
HPRD ID
03758
14767
Ensembl ID
ENSG00000130713
ENSG00000175581
Uniprot IDs
B3KQW2
Q13868
F5H702
F5H8D0
Q96GC5
PDB IDs
2NN6
6D6Q
6D6R
6H25
9G8M
9G8N
9G8O
9G8P
3J7Y
3J9M
5OOL
5OOM
6I9R
6NU2
6NU3
6VLZ
6VMI
6ZM5
6ZM6
6ZS9
6ZSA
6ZSB
6ZSC
6ZSD
6ZSE
6ZSG
7A5F
7A5G
7A5H
7A5I
7A5J
7A5K
7L08
7L20
7O9K
7O9M
7ODR
7ODS
7ODT
7OF0
7OF2
7OF3
7OF4
7OF5
7OF6
7OF7
7OG4
7OI7
7OI8
7OI9
7OIA
7OIB
7OIC
7OID
7OIE
7PD3
7PO4
7QH7
7QI4
7QI5
7QI6
8ANY
8K2A
8K2B
8OIR
8OIT
8PK0
8QSJ
8QU5
8RRI
8XT0
8XT1
8XT2
8XT3
Enriched GO Terms of Interacting Partners
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Exosome (RNase Complex)
Nuclear Exosome (RNase Complex)
Nuclear MRNA Surveillance
Cytoplasmic Exosome (RNase Complex)
RRNA Catabolic Process
U4 SnRNA 3'-end Processing
Nucleolar Exosome (RNase Complex)
RNA Exonuclease Activity
Exoribonuclease Complex
Nuclear RNA Surveillance
RNA Surveillance
SnRNA 3'-end Processing
SnRNA Metabolic Process
Nuclear-transcribed MRNA Catabolic Process
SnRNA Processing
RNA Catabolic Process
MRNA Catabolic Process
MRNA 3'-UTR AU-rich Region Binding
3'-5'-RNA Exonuclease Activity
RRNA Processing
Nucleobase-containing Compound Catabolic Process
U5 SnRNA 3'-end Processing
U1 SnRNA 3'-end Processing
RNA 3'-end Processing
RRNA Metabolic Process
MRNA Metabolic Process
Macromolecule Catabolic Process
Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA)
TRNA Surveillance
TRAMP-dependent TRNA Surveillance Pathway
Nuclear Polyadenylation-dependent RRNA Catabolic Process
Poly(A)-dependent SnoRNA 3'-end Processing
RRNA 3'-end Processing
TRNA Decay
DNA Deamination
Sno(s)RNA Metabolic Process
RNA Processing
DNA Modification
Nucleolus
RNA Binding
Catabolic Process
RNA Metabolic Process
Negative Regulation Of Gene Expression
Macromolecule Metabolic Process
Nucleic Acid Metabolic Process
Histone MRNA Catabolic Process
3'-UTR-mediated MRNA Destabilization
Maturation Of 5.8S RRNA
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Acetylcholine Receptor Activator Activity
Amyloid-beta Complex
PTB Domain Binding
Regulation Of Spontaneous Synaptic Transmission
Growth Cone Lamellipodium
Axon Choice Point Recognition
Collateral Sprouting In Absence Of Injury
Protein Complex Oligomerization
Regulation Of Protein Import
Response To Norepinephrine
Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Intermediate-density Lipoprotein Particle
Regulation Of Response To Calcium Ion
Axon Midline Choice Point Recognition
NMDA Selective Glutamate Receptor Signaling Pathway
Amylin Binding
Regulation Of Synapse Structure Or Activity
Endosome To Plasma Membrane Transport Vesicle
Protein Tetramerization
Positive Regulation Of Amyloid Fibril Formation
Positive Regulation Of Toll Signaling Pathway
Positive Regulation Of Endothelin Production
Growth Cone Filopodium
Cellular Response To Norepinephrine Stimulus
Regulation Of Toll Signaling Pathway
Lipoprotein Particle
Growth Factor Receptor Binding
Main Axon
Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Protein Import
Astrocyte Activation Involved In Immune Response
Microglia Development
Positive Regulation Of G Protein-coupled Receptor Internalization
Low-density Lipoprotein Particle Mediated Signaling
Proton-transporting ATP Synthase Complex Assembly
Mitochondrial Ribosome Binding
Mitochondrial Proton-transporting ATP Synthase Complex Assembly
Mitochondrial Protein Quality Control
Protein Insertion Into Mitochondrial Inner Membrane From Matrix
Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA)
7S RNA Binding
TRAMP-dependent TRNA Surveillance Pathway
TRNA Surveillance
Nuclear Polyadenylation-dependent RRNA Catabolic Process
CUT Catabolic Process
Lsm2-8 Complex
Heparan Sulfate Binding
Signaling Receptor Activator Activity
Negative Regulation Of Oxidoreductase Activity
U4 SnRNA 3'-end Processing
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Tagcloud (Intersection)
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