SNX27 and ACVR2B

Number of citations of the paper that reports this interaction (PubMedID 23722234)
86

Data Source:
BioGRID (two hybrid)

		SNX27	ACVR2B
Description		sorting nexin 27	activin A receptor type 2B
Image
GO Annotations	Cellular Component	Immunological Synapse Cytoplasm Endosome Early Endosome Cytosol Membrane Retromer Complex Early Endosome Membrane WASH Complex Schaffer Collateral - CA1 Synapse Postsynapse Postsynaptic Recycling Endosome Postsynaptic Early Endosome Glutamatergic Synapse	Cytoplasm Plasma Membrane Membrane Protein-containing Complex Receptor Complex Activin Receptor Complex
	Molecular Function	Protein Binding Lipid Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Activin Receptor Activity, Type II Transferase Activity Activin Receptor Activity Kinase Activator Activity Growth Factor Binding Metal Ion Binding Activin Binding
	Biological Process	Establishment Of Natural Killer Cell Polarity Intracellular Protein Transport Signal Transduction Endosome To Lysosome Transport Protein Transport Endosomal Transport Endocytic Recycling Regulation Of Synapse Maturation Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Gastrulation With Mouth Forming Second Kidney Development Lymphangiogenesis Blood Vessel Remodeling Regulation Of DNA-templated Transcription Intracellular Iron Ion Homeostasis Signal Transduction Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Determination Of Left/right Symmetry Pattern Specification Process Mesoderm Development Heart Development Response To Glucose Post-embryonic Development Anterior/posterior Pattern Specification Regulation Of Signal Transduction Insulin Secretion Negative Regulation Of Ossification Lung Development Positive Regulation Of Bone Mineralization BMP Signaling Pathway Pancreas Development Developmental Process Activin Receptor Signaling Pathway Positive Regulation Of Activin Receptor Signaling Pathway Organ Growth Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Osteoblast Differentiation Embryonic Foregut Morphogenesis Skeletal System Morphogenesis Roof Of Mouth Development Lymphatic Endothelial Cell Differentiation Artery Development Venous Blood Vessel Development Retina Vasculature Development In Camera-type Eye Trophoblast Cell Migration Cellular Response To Growth Factor Stimulus Negative Regulation Of Cold-induced Thermogenesis Negative Regulation Of Adipose Tissue Development
Pathways			Signaling by NODAL Regulation of signaling by NODAL Signaling by Activin Signaling by Activin Signaling by BMP
Drugs
Diseases			Heterotaxy; Situs ambiguus
GWAS		Body mass index ( 26426971)	Bitter beverage consumption ( 31046077) Body size at age 10 ( 32376654) Estimated glomerular filtration rate ( 31015462 31152163) P wave duration ( 24850809)
Interacting Genes		16 interacting genes: ACE2 ACVR2B APP BRSK2 CDK16 DGKZ ERBB4 HLCS PDGFRB PNPLA3 PTEN RPS6KA1 SELP SUMO2 UBC VANGL2	26 interacting genes: ACVR1B BMP10 BMP2 BMP7 CRIPTO DLG1 ERBIN FBXO7 GDF11 GDF2 GDF5 IGSF1 INHBA INHBB INHBC MSTN NHERF2 NODAL SCRIB SNTB1 SNX1 SNX2 SNX27 SNX6 SYNJ2BP TGFBRAP1
Entrez ID		81609	93
HPRD ID		11591	04106
Ensembl ID		ENSG00000143376	ENSG00000114739
Uniprot IDs		A0A2R8Y8A7 Q96L92	Q13705
PDB IDs		4HAS 5ZN9 6SAK 7CT1 7E0B 7P72 7PCB 8TTT 8TTU 8TTV	2H62 2QLU 4FAO 5NGV 5NHR 7MRZ 7OLY
Enriched GO Terms of Interacting Partners?		Kinase Activity Protein Metabolic Process Phosphorylation Regulation Of Cell Communication Protein Kinase Activity Regulation Of Signaling Protein Modification Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Migration Phosphate-containing Compound Metabolic Process Protein Phosphorylation Regulation Of Synaptic Vesicle Clustering ATP Binding Cell Motility Receptor Complex Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Nucleotide Binding Transferase Activity Regulation Of Signal Transduction Retina Vasculature Development In Camera-type Eye Protein Tag Activity Cellular Response To Growth Factor Stimulus Regulation Of ERK1 And ERK2 Cascade Macromolecule Metabolic Process Response To Growth Factor Anatomical Structure Morphogenesis Establishment Of Planar Polarity System Development Regulation Of Reactive Oxygen Species Metabolic Process Phosphatidic Acid Biosynthetic Process Protein Serine/threonine/tyrosine Kinase Activity Apical Plasma Membrane Regulation Of Smooth Muscle Cell Proliferation Axonogenesis Protein Serine/threonine Kinase Activity Enzyme Binding Positive Regulation Of Excitatory Postsynaptic Potential Reproductive Behavior Phosphatidic Acid Metabolic Process Plasma Membrane Glycerophospholipid Biosynthetic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Proteolysis Amyloid-beta Complex Regulation Of Cellular Component Organization Growth Cone Lamellipodium Neuron Projection Organization Regulation Of Response To Calcium Ion	Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Growth Factor Activity Activin Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cytokine Activity Positive Regulation Of SMAD Protein Signal Transduction Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of SMAD Protein Signal Transduction Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Cell Population Proliferation Positive Regulation Of Cartilage Development Regulation Of Signaling Regulation Of Signal Transduction BMP Signaling Pathway Cell Surface Receptor Signaling Pathway Negative Regulation Of Developmental Process Anatomical Structure Morphogenesis Retromer, Tubulation Complex Regulation Of Cell Communication Retromer Complex Regulation Of Cell Population Proliferation Negative Regulation Of Cell Differentiation Regulation Of Intracellular Signal Transduction Regulation Of Developmental Process Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Extracellular Space Regulation Of Cartilage Development Negative Regulation Of Signaling Negative Regulation Of Cell Communication Signal Transduction Signaling Receptor Binding Regulation Of Multicellular Organismal Process Tissue Morphogenesis Regulation Of Cell Differentiation Morphogenesis Of A Branching Structure Cellular Response To Growth Factor Stimulus Regulation Of Locomotion Tube Morphogenesis Regulation Of Reproductive Process Response To Growth Factor Animal Organ Development Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Multicellular Organismal Development Cartilage Development Morphogenesis Of An Epithelium Extracellular Region Nodal Signaling Pathway Mesoderm Formation
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?