SNX27 and VANGL2

Number of citations of the paper that reports this interaction (PubMedID 23722234)
86

Data Source:
BioGRID (two hybrid, affinity chromatography technology, imaging technique, affinity chromatography technology)

		SNX27	VANGL2
Description		sorting nexin 27	VANGL planar cell polarity protein 2
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GO Annotations	Cellular Component	Immunological Synapse Cytoplasm Endosome Early Endosome Cytosol Membrane Retromer Complex Early Endosome Membrane WASH Complex Schaffer Collateral - CA1 Synapse Postsynapse Postsynaptic Recycling Endosome Postsynaptic Early Endosome Glutamatergic Synapse	Stress Fiber Plasma Membrane Cell-cell Junction Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane COPII-coated ER To Golgi Transport Vesicle Cell Pole Cell Periphery Apical Cytoplasm Postsynaptic Density Membrane Glutamatergic Synapse
	Molecular Function	Protein Binding Lipid Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol Binding	Protein Binding
	Biological Process	Establishment Of Natural Killer Cell Polarity Intracellular Protein Transport Signal Transduction Endosome To Lysosome Transport Protein Transport Endosomal Transport Endocytic Recycling Regulation Of Synapse Maturation Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels	Establishment Of Planar Polarity Neural Tube Closure Hair Follicle Development Heart Looping Membranous Septum Morphogenesis Muscular Septum Morphogenesis Rho Protein Signal Transduction Anterior/posterior Pattern Specification Heparan Sulfate Proteoglycan Biosynthetic Process Convergent Extension Involved In Neural Plate Elongation Regulation Of Wnt Signaling Pathway Glomerulus Development Regulation Of Actin Cytoskeleton Organization Somatic Stem Cell Population Maintenance Non-canonical Wnt Signaling Pathway Cell Migration Involved In Kidney Development Post-anal Tail Morphogenesis Dopaminergic Neuron Axon Guidance Serotonergic Neuron Axon Guidance Wound Healing Apical Protein Localization Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Somatic Stem Cell Division Establishment Of Body Hair Planar Orientation Digestive Tract Morphogenesis Convergent Extension Involved In Axis Elongation Convergent Extension Involved In Organogenesis Wnt Signaling Pathway, Planar Cell Polarity Pathway Inner Ear Receptor Cell Development Inner Ear Receptor Cell Stereocilium Organization Orthogonal Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Morphogenesis Planar Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Morphogenesis Lateral Sprouting Involved In Lung Morphogenesis Kidney Morphogenesis Cochlea Development Cochlea Morphogenesis Regulation Of Establishment Of Planar Polarity Establishment Of Planar Polarity Involved In Neural Tube Closure Non-motile Cilium Assembly Regulation Of Synapse Pruning
Pathways			PCP/CE pathway Asymmetric localization of PCP proteins RND3 GTPase cycle RND2 GTPase cycle RND1 GTPase cycle
Drugs
Diseases
GWAS		Body mass index ( 26426971)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cognitive performance ( 19734545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Left-handedness ( 32989287) Multiple sclerosis ( 24076602 31604244) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Systemic lupus erythematosus ( 28714469)
Interacting Genes		16 interacting genes: ACE2 ACVR2B APP BRSK2 CDK16 DGKZ ERBB4 HLCS PDGFRB PNPLA3 PTEN RPS6KA1 SELP SUMO2 UBC VANGL2	27 interacting genes: AP1M1 ARFRP1 ARHGEF12 DLG2 DLG4 DVL1 GIPC1 KBTBD7 LIN7A LRRC7 MAGI2 MAGI3 MAST1 MAST2 MPDZ PDZRN3 PTPN13 PTPN4 SCRIB SNTA1 SNTB1 SNTG1 SNTG2 SNX27 SQSTM1 SYNJ2BP VCP
Entrez ID		81609	57216
HPRD ID		11591	02758
Ensembl ID		ENSG00000143376	ENSG00000162738
Uniprot IDs		A0A2R8Y8A7 Q96L92	A8K4L6 Q9ULK5
PDB IDs		4HAS 5ZN9 6SAK 7CT1 7E0B 7P72 7PCB 8TTT 8TTU 8TTV	6XA6 6XA7 6XA8 7R2M 7R2T 9JK7 9JKA
Enriched GO Terms of Interacting Partners?		Kinase Activity Protein Metabolic Process Phosphorylation Regulation Of Cell Communication Protein Kinase Activity Regulation Of Signaling Protein Modification Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Migration Phosphate-containing Compound Metabolic Process Protein Phosphorylation Regulation Of Synaptic Vesicle Clustering ATP Binding Cell Motility Receptor Complex Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Nucleotide Binding Transferase Activity Regulation Of Signal Transduction Retina Vasculature Development In Camera-type Eye Protein Tag Activity Cellular Response To Growth Factor Stimulus Regulation Of ERK1 And ERK2 Cascade Macromolecule Metabolic Process Response To Growth Factor Anatomical Structure Morphogenesis Establishment Of Planar Polarity System Development Regulation Of Reactive Oxygen Species Metabolic Process Phosphatidic Acid Biosynthetic Process Protein Serine/threonine/tyrosine Kinase Activity Apical Plasma Membrane Regulation Of Smooth Muscle Cell Proliferation Axonogenesis Protein Serine/threonine Kinase Activity Enzyme Binding Positive Regulation Of Excitatory Postsynaptic Potential Reproductive Behavior Phosphatidic Acid Metabolic Process Plasma Membrane Glycerophospholipid Biosynthetic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Proteolysis Amyloid-beta Complex Regulation Of Cellular Component Organization Growth Cone Lamellipodium Neuron Projection Organization Regulation Of Response To Calcium Ion	Receptor Clustering Synapse Dystrophin-associated Glycoprotein Complex Syntrophin Complex Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Postsynaptic Density Establishment Of Protein Localization Protein Localization To Membrane Localization Within Membrane Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Receptor Localization To Synapse Intracellular Protein Transport Establishment Or Maintenance Of Apical/basal Cell Polarity Protein Localization To Synapse Endosomal Transport Establishment Or Maintenance Of Cell Polarity Intracellular Protein Localization Vesicle-mediated Transport Neuromuscular Junction Beta-1 Adrenergic Receptor Binding PDZ Domain Binding Cellular Localization Protein Localization To Cell Junction Neuron Projection Ionotropic Glutamate Receptor Binding Protein Localization To Postsynaptic Membrane Protein Localization To Postsynapse Cytoplasm Glutamatergic Synapse Neuroligin Family Protein Binding Protein Transport Anchoring Junction Bicellular Tight Junction Vesicle-mediated Transport To The Plasma Membrane Protein Kinase Binding Establishment Of Localization In Cell Positive Regulation Of Neuron Projection Arborization GMP Kinase Activity Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Neurotransmitter Receptor Transport, Endosome To Plasma Membrane Establishment Of Protein Localization To Plasma Membrane Regulation Of Synapse Organization Ubiquitin-modified Protein Reader Activity Neurotransmitter Receptor Transport To Postsynaptic Membrane GDP Metabolic Process Establishment Of Protein Localization To Postsynaptic Membrane Neurotransmitter Receptor Transport To Plasma Membrane Juxtaparanode Region Of Axon Protein-containing Complex Localization Structural Molecule Activity
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