SNX27 and DGKZ

Number of citations of the paper that reports this interaction (PMID 17351151)
19

Data Source:
HPRD (in vivo, two hybrid)

		SNX27	DGKZ
Gene Name		sorting nexin family member 27	diacylglycerol kinase, zeta
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Immunological Synapse Nucleoplasm Cytoplasm Early Endosome Cytosol Retromer Complex Early Endosome Membrane WASH Complex	Nucleus Nucleoplasm Cytoplasm Plasma Membrane Lamellipodium
	Molecular Function	Protein Binding Phosphatidylinositol-3-phosphate Binding	Lipid Kinase Activity NAD+ Kinase Activity Diacylglycerol Kinase Activity Enzyme Inhibitor Activity Protein Binding ATP Binding Protein C-terminus Binding Metal Ion Binding
	Biological Process	Establishment Of Natural Killer Cell Polarity Intracellular Protein Transport Signal Transduction Endosome To Lysosome Transport Endosomal Transport Retrograde Transport, Endosome To Plasma Membrane	Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Blood Coagulation Phosphorylation Cell Migration Platelet Activation Mitotic G1 DNA Damage Checkpoint Intracellular Signal Transduction Negative Regulation Of Catalytic Activity Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Ras Protein Signal Transduction Lipid Phosphorylation
Pathways			G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK Platelet activation, signaling and aggregation Effects of PIP2 hydrolysis
Drugs
Diseases
GWAS			Immunoglobulin A ( 20694011)
Protein-Protein Interactions		6 interactors: AKT2 APP DGKZ HLCS PNPLA3 SELP	18 interactors: DMD HRAS LEPR MAPK6 PLCG1 POLR2M PRKCA RASGRP1 RB1 RBL1 RBL2 SAT1 SNTA1 SNTB1 SNTB2 SNTG1 SNX27 SRC
Entrez ID		81609	8525
HPRD ID		11591	03260
Ensembl ID		ENSG00000143376	ENSG00000149091
Uniprot IDs		Q96L92	B7Z6M3 F6UCU9 Q13574
PDB IDs		4HAS
Enriched GO Terms of Interacting Partners?		Platelet Activation Blood Coagulation Hemostasis Platelet Degranulation Regulation Of Cell Cycle Process Protein Biotinylation Histone Biotinylation Regulation Of Body Fluid Levels Wound Healing Cell Activation Response To Wounding Synaptic Growth At Neuromuscular Junction Response To Biotin Selenium Compound Metabolic Process Collateral Sprouting In Absence Of Injury Activation Of Ral GTPase Activity Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport Regulation Of Cell Cycle Collateral Sprouting Axon Midline Choice Point Recognition Acylglycerol Acyl-chain Remodeling Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Glucose Import In Response To Insulin Stimulus Locomotory Behavior Axon Choice Point Recognition Positive Regulation Of Ral GTPase Activity Regulation Of Ral Protein Signal Transduction Positive Regulation Of Platelet Activation Regulation Of Translation Regulation Of Signal Transduction Neuron Remodeling Phosphate-containing Compound Metabolic Process Locomotion Regulation Of Glucose Import In Response To Insulin Stimulus Positive Regulation Of Fatty Acid Beta-oxidation Regulation Of Integrin Activation Lipid Metabolic Process Positive Regulation Of Cell Motility Exocytosis Positive Regulation Of Vesicle Fusion Biotin Metabolic Process Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Positive Regulation Of Glycogen Biosynthetic Process Peripheral Nervous System Myelin Maintenance Leukocyte Tethering Or Rolling Regulation Of Signaling Regulation Of Mitotic Cell Cycle	Regulation Of Lipid Kinase Activity Regulation Of Kinase Activity Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Phosphorylation Negative Regulation Of Peptidyl-cysteine S-nitrosylation Regulation Of Phosphorus Metabolic Process Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cell Communication Cellular Response To Fibroblast Growth Factor Stimulus Blood Coagulation Response To Fibroblast Growth Factor Hemostasis Regulation Of Catalytic Activity Neurotrophin TRK Receptor Signaling Pathway Ras Protein Signal Transduction Neurotrophin Signaling Pathway Intracellular Signal Transduction Leukocyte Migration Cell Cycle Regulation Of Cell Cycle Positive Regulation Of Macrophage Differentiation Fc Receptor Signaling Pathway Regulation Of Body Fluid Levels Cellular Response To Growth Factor Stimulus Wound Healing Response To Growth Factor Regulation Of Lipid Metabolic Process Regulation Of Cellular Localization Signaling Regulation Of Protein Phosphorylation Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Cellular Component Movement Regulation Of Cellular Component Movement Response To Wounding Positive Regulation Of Locomotion Positive Regulation Of ERK1 And ERK2 Cascade Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Protein Kinase Activity Mitotic Cell Cycle Regulation Of Epithelial Cell Migration Negative Regulation Of Catalytic Activity Regulation Of Muscle Contraction Organelle Localization Signal Transduction Regulation Of Immune System Process Innate Immune Response
Tagcloud ?		40s aav abeta adeno associates decreasing diminishing dissociates downregulation ds elevation encoded establishes glutamate hippocampal impairing invariably microrna modulating presenilin promoted proteolytic recycling reversed rnai secretase trafficking vector
Tagcloud (Difference) ?		40s aav abeta adeno associates decreasing diminishing dissociates downregulation ds elevation encoded establishes glutamate hippocampal impairing invariably microrna modulating presenilin promoted proteolytic recycling reversed rnai secretase trafficking vector
Tagcloud (Intersection) ?