SNX27 and BRSK2

Number of citations of the paper that reports this interaction (PubMedID 23722234)
86

Data Source:
BioGRID (two hybrid)

		SNX27	BRSK2
Description		sorting nexin 27	BR serine/threonine kinase 2
Image			No pdb structure
GO Annotations	Cellular Component	Immunological Synapse Cytoplasm Endosome Early Endosome Cytosol Membrane Retromer Complex Early Endosome Membrane WASH Complex Schaffer Collateral - CA1 Synapse Postsynapse Postsynaptic Recycling Endosome Postsynaptic Early Endosome Glutamatergic Synapse	Cytoplasm Endoplasmic Reticulum Centrosome Cytoskeleton Perinuclear Region Of Cytoplasm Distal Axon
	Molecular Function	Protein Binding Lipid Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol Binding	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Metal Ion Binding Tau Protein Binding Tau-protein Kinase Activity ATPase Binding ATPase Regulator Activity Protein Serine Kinase Activity
	Biological Process	Establishment Of Natural Killer Cell Polarity Intracellular Protein Transport Signal Transduction Endosome To Lysosome Transport Protein Transport Endosomal Transport Endocytic Recycling Regulation Of Synapse Maturation Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels	G2/M Transition Of Mitotic Cell Cycle Protein Phosphorylation Exocytosis Apoptotic Process Nervous System Development Axonogenesis Regulation Of Neuron Projection Development Central Nervous System Neuron Differentiation Establishment Of Cell Polarity Actin Cytoskeleton Organization Neuron Differentiation ERAD Pathway Neuron Projection Morphogenesis Regulation Of Axonogenesis Cell Division Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Microtubule Cytoskeleton Organization Involved In Establishment Of Planar Polarity Regulation Of Retrograde Protein Transport, ER To Cytosol Regulation Of Synaptic Vesicle Clustering
Pathways
Drugs
Diseases
GWAS		Body mass index ( 26426971)	Brain morphology (MOSTest) ( 32665545) Gout ( 32238385) Heroin dependence ( 27936112) Idiopathic pulmonary fibrosis ( 24429156)
Interacting Genes		16 interacting genes: ACE2 ACVR2B APP BRSK2 CDK16 DGKZ ERBB4 HLCS PDGFRB PNPLA3 PTEN RPS6KA1 SELP SUMO2 UBC VANGL2	12 interacting genes: CDC25B CDC25C COPS5 MAGI3 MAPT NHERF1 NHERF2 SCRIB SNX27 TRAF6 VCP WEE1
Entrez ID		81609	9024
HPRD ID		11591	11611
Ensembl ID		ENSG00000143376	ENSG00000174672
Uniprot IDs		A0A2R8Y8A7 Q96L92	A0A140VJF6 B4DLY3 Q8IWQ3
PDB IDs		4HAS 5ZN9 6SAK 7CT1 7E0B 7P72 7PCB 8TTT 8TTU 8TTV
Enriched GO Terms of Interacting Partners?		Kinase Activity Protein Metabolic Process Phosphorylation Regulation Of Cell Communication Protein Kinase Activity Regulation Of Signaling Protein Modification Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Migration Phosphate-containing Compound Metabolic Process Protein Phosphorylation Regulation Of Synaptic Vesicle Clustering ATP Binding Cell Motility Receptor Complex Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Nucleotide Binding Transferase Activity Regulation Of Signal Transduction Retina Vasculature Development In Camera-type Eye Protein Tag Activity Cellular Response To Growth Factor Stimulus Regulation Of ERK1 And ERK2 Cascade Macromolecule Metabolic Process Response To Growth Factor Anatomical Structure Morphogenesis Establishment Of Planar Polarity System Development Regulation Of Reactive Oxygen Species Metabolic Process Phosphatidic Acid Biosynthetic Process Protein Serine/threonine/tyrosine Kinase Activity Apical Plasma Membrane Regulation Of Smooth Muscle Cell Proliferation Axonogenesis Protein Serine/threonine Kinase Activity Enzyme Binding Positive Regulation Of Excitatory Postsynaptic Potential Reproductive Behavior Phosphatidic Acid Metabolic Process Plasma Membrane Glycerophospholipid Biosynthetic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Proteolysis Amyloid-beta Complex Regulation Of Cellular Component Organization Growth Cone Lamellipodium Neuron Projection Organization Regulation Of Response To Calcium Ion	Positive Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of G2/MI Transition Of Meiotic Cell Cycle Establishment Of Cell Polarity Type 3 Metabotropic Glutamate Receptor Binding Type 2 Metabotropic Glutamate Receptor Binding Regulation Of Protein Modification Process Establishment Or Maintenance Of Cell Polarity G2/M Transition Of Mitotic Cell Cycle Cell Cycle G2/M Phase Transition Regulation Of G2/MI Transition Of Meiotic Cell Cycle Regulation Of Mitotic Cell Cycle Inclusion Body Assembly Regulation Of Protein Metabolic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Regulation Of G2/M Transition Of Mitotic Cell Cycle Auditory Receptor Cell Stereocilium Organization Positive Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Mitotic Cell Cycle Establishment Of Apical/basal Cell Polarity Positive Regulation Of Meiotic Cell Cycle Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Polarized Epithelial Cell Differentiation Mitotic Cell Cycle Phase Transition Regulation Of Protein Localization To Synapse Cell Cycle Phase Transition Protein Kinase Binding Protein-membrane Adaptor Activity Inner Ear Receptor Cell Stereocilium Organization Cellular Localization Protein Localization To Plasma Membrane Establishment Of Localization In Cell Localization Within Membrane Negative Regulation Of Mitotic Cell Cycle Cytoplasm Regulation Of Catalytic Activity Glutamatergic Synapse Protein Localization To Cell Periphery Immunological Synapse Regulation Of Phosphorus Metabolic Process Regulation Of Protein Kinase Activity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Cell Cycle Process Regulation Of Kinase Activity Histone-dependent DNA Binding Tubulin Complex Microtubule Lateral Binding
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