SNX27 and PNPLA3

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		SNX27	PNPLA3
Gene Name		sorting nexin family member 27	patatin-like phospholipase domain containing 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Immunological Synapse Nucleoplasm Cytoplasm Early Endosome Cytosol Retromer Complex Early Endosome Membrane WASH Complex	Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding Phosphatidylinositol-3-phosphate Binding	Phospholipase A2 Activity Triglyceride Lipase Activity Mono-olein Transacylation Activity Diolein Transacylation Activity
	Biological Process	Establishment Of Natural Killer Cell Polarity Intracellular Protein Transport Signal Transduction Endosome To Lysosome Transport Endosomal Transport Retrograde Transport, Endosome To Plasma Membrane	Phospholipid Metabolic Process Triglyceride Biosynthetic Process Triglyceride Catabolic Process Acylglycerol Acyl-chain Remodeling Small Molecule Metabolic Process Glycerophospholipid Biosynthetic Process
Pathways			Metabolism of lipids and lipoproteins Acyl chain remodeling of DAG and TAG Phospholipid metabolism Glycerophospholipid biosynthesis
Drugs
Diseases
GWAS			Hematological and biochemical traits ( 20139978) Liver enzyme levels ( 18940312) Liver enzyme levels (alanine transaminase) ( 22001757) Metabolite levels ( 21909109) Non-alcoholic fatty liver disease ( 23535911) Nonalcoholic fatty liver disease ( 21423719 22719876)
Protein-Protein Interactions		6 interactors: AKT2 APP DGKZ HLCS PNPLA3 SELP	2 interactors: AKT2 SNX27
Entrez ID		81609	80339
HPRD ID		11591	12430
Ensembl ID		ENSG00000143376	ENSG00000100344
Uniprot IDs		Q96L92	Q9NST1
PDB IDs		4HAS
Enriched GO Terms of Interacting Partners?		Platelet Activation Blood Coagulation Hemostasis Platelet Degranulation Regulation Of Cell Cycle Process Protein Biotinylation Histone Biotinylation Regulation Of Body Fluid Levels Wound Healing Cell Activation Response To Wounding Synaptic Growth At Neuromuscular Junction Response To Biotin Selenium Compound Metabolic Process Collateral Sprouting In Absence Of Injury Activation Of Ral GTPase Activity Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport Regulation Of Cell Cycle Collateral Sprouting Axon Midline Choice Point Recognition Acylglycerol Acyl-chain Remodeling Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Glucose Import In Response To Insulin Stimulus Locomotory Behavior Axon Choice Point Recognition Positive Regulation Of Ral GTPase Activity Regulation Of Ral Protein Signal Transduction Positive Regulation Of Platelet Activation Regulation Of Translation Regulation Of Signal Transduction Neuron Remodeling Phosphate-containing Compound Metabolic Process Locomotion Regulation Of Glucose Import In Response To Insulin Stimulus Positive Regulation Of Fatty Acid Beta-oxidation Regulation Of Integrin Activation Lipid Metabolic Process Positive Regulation Of Cell Motility Exocytosis Positive Regulation Of Vesicle Fusion Biotin Metabolic Process Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Positive Regulation Of Glycogen Biosynthetic Process Peripheral Nervous System Myelin Maintenance Leukocyte Tethering Or Rolling Regulation Of Signaling Regulation Of Mitotic Cell Cycle	Establishment Of Natural Killer Cell Polarity Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport Activation Of Ral GTPase Activity Positive Regulation Of Glucose Import In Response To Insulin Stimulus Positive Regulation Of Ral GTPase Activity Regulation Of Ral Protein Signal Transduction Retrograde Transport, Endosome To Plasma Membrane Positive Regulation Of Fatty Acid Beta-oxidation Regulation Of Glucose Import In Response To Insulin Stimulus Positive Regulation Of Vesicle Fusion Positive Regulation Of Glycogen Biosynthetic Process Peripheral Nervous System Myelin Maintenance Positive Regulation Of Fatty Acid Oxidation Regulation Of Fatty Acid Beta-oxidation Intracellular Protein Transport Mammary Gland Epithelial Cell Differentiation Positive Regulation Of Protein Targeting To Membrane Myelin Maintenance Negative Regulation Of Lipid Transport Positive Regulation Of Lipid Catabolic Process Glycogen Biosynthetic Process Regulation Of Vesicle Fusion Endosome To Lysosome Transport Regulation Of Glycogen Biosynthetic Process Regulation Of Fatty Acid Oxidation Positive Regulation Of Fatty Acid Metabolic Process Regulation Of Fatty Acid Transport Positive Regulation Of Glucose Metabolic Process Positive Regulation Of Glucose Import Myelination In Peripheral Nervous System Regulation Of Glycogen Metabolic Process Cellular Polysaccharide Biosynthetic Process Cellular Protein Localization Positive Regulation Of Glucose Transport Schwann Cell Development Intracellular Protein Transmembrane Transport Protein Transport Polysaccharide Biosynthetic Process Lysosomal Transport Activation Of Ras GTPase Activity Establishment Of Protein Localization Negative Regulation Of Ion Transmembrane Transport Intracellular Transport Protein Transmembrane Transport Negative Regulation Of Transmembrane Transport Schwann Cell Differentiation Regulation Of Glucose Import Regulation Of Lipid Catabolic Process Glycogen Metabolic Process Natural Killer Cell Activation
Tagcloud ?		40s aav abeta adeno associates decreasing diminishing dissociates downregulation ds elevation encoded establishes glutamate hippocampal impairing invariably microrna modulating presenilin promoted proteolytic recycling reversed rnai secretase trafficking vector	clues depdc5 directions dp dq exome g1896a gwass hbv hepatocarcinogenesis hla hotspots htert integrations kif1b landscape mica mutational pose possibilities rtm204i rtm204v shall technologies threats throughput transitions underlined warrant
Tagcloud (Difference) ?		40s aav abeta adeno associates decreasing diminishing dissociates downregulation ds elevation encoded establishes glutamate hippocampal impairing invariably microrna modulating presenilin promoted proteolytic recycling reversed rnai secretase trafficking vector	clues depdc5 directions dp dq exome g1896a gwass hbv hepatocarcinogenesis hla hotspots htert integrations kif1b landscape mica mutational pose possibilities rtm204i rtm204v shall technologies threats throughput transitions underlined warrant
Tagcloud (Intersection) ?