PPFIBP2 and PTPRC

Number of citations of the paper that reports this interaction (PMID 9624153)
49

Data Source:
HPRD (in vitro)

		PPFIBP2	PTPRC
Gene Name		PTPRF interacting protein, binding protein 2 (liprin beta 2)	protein tyrosine phosphatase, receptor type, C
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Intracellular	Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Membrane Membrane Raft Extracellular Vesicular Exosome
	Molecular Function	Molecular_function	Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Protein Kinase Binding
	Biological Process		Negative Regulation Of T Cell Mediated Cytotoxicity Negative Regulation Of Cytokine-mediated Signaling Pathway Hematopoietic Progenitor Cell Differentiation Immunoglobulin Biosynthetic Process Negative Regulation Of Protein Kinase Activity Protein Dephosphorylation Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration Cell Surface Receptor Signaling Pathway Axon Guidance Dephosphorylation T Cell Differentiation Positive Regulation Of B Cell Proliferation Peptidyl-tyrosine Dephosphorylation B Cell Proliferation Positive Regulation Of T Cell Proliferation Cell Cycle Phase Transition Positive Regulation Of Protein Kinase Activity Bone Marrow Development Stem Cell Development T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Positive Regulation Of Antigen Receptor-mediated Signaling Pathway Release Of Sequestered Calcium Ion Into Cytosol Defense Response To Virus Regulation Of Cell Cycle Positive Regulation Of Hematopoietic Stem Cell Migration Positive Regulation Of Stem Cell Proliferation
Pathways			TCR signaling Axon guidance Semaphorin interactions Other semaphorin interactions Phosphorylation of CD3 and TCR zeta chains Adaptive Immune System
Drugs
Diseases
GWAS			Mean corpuscular hemoglobin ( 20139978)
Protein-Protein Interactions		10 interactors: APP CRK CRKL DTNB PPFIA1 PPFIA2 PPFIA3 PRNP PTPRC TSG101	43 interactors: ANP32A CD1D CD2 CD22 CD247 CD28 CD4 CD8A CSNK2A1 CSNK2A2 CXCR4 DPP4 EZR FCGR3A FYN GANAB GRB2 IFNAR1 INSR IRS1 ITGAL JAK1 JAK2 JAK3 LCK LCP2 LGALS1 LSM1 LYN MBL2 PAEP PPFIA1 PPFIBP2 PRKCSH PTPN6 PTPRCAP RASA1 RNF11 SEMA4D SKAP1 TYK2 UHRF2 ZAP70
Entrez ID		8495	5788
HPRD ID		04391	01050
Ensembl ID		ENSG00000166387	ENSG00000081237
Uniprot IDs		Q8ND30	M9MML4 P08575
PDB IDs		3QH9	1YGR 1YGU
Enriched GO Terms of Interacting Partners?		Glutamate Secretion Acid Secretion Dicarboxylic Acid Transport Neurotransmitter Secretion Regulation Of Neurotransmitter Levels Regulation Of Protein Phosphorylation Cellular Copper Ion Homeostasis Secretion By Cell Establishment Of Localization In Cell Amino Acid Transport Neurotransmitter Transport Copper Ion Homeostasis Regulation Of Phosphorylation Secretion Cellular Localization Regulation Of Phosphorus Metabolic Process Regulation Of Protein Kinase Activity Activation Of Protein Kinase Activity Regulation Of Kinase Activity Carboxylic Acid Transport Organic Acid Transport Regulation Of Cell Cycle Activation Of MAPKK Activity Regulation Of Signaling Axon Guidance Regulation Of Cellular Protein Metabolic Process Cellular Metal Ion Homeostasis Transport Organic Anion Transport Cellular Cation Homeostasis Positive Regulation Of MAPK Cascade Positive Regulation Of Cellular Protein Metabolic Process Cellular Ion Homeostasis Positive Regulation Of Protein Kinase Activity Metal Ion Homeostasis Regulation Of Protein Metabolic Process Cell Adhesion Positive Regulation Of Kinase Activity Positive Regulation Of Protein Metabolic Process Immunoglobulin Biosynthetic Process Synaptic Growth At Neuromuscular Junction Positive Regulation Of Hematopoietic Stem Cell Migration Axonogenesis Cellular Chemical Homeostasis Signaling Positive Regulation Of Transferase Activity Ion Homeostasis Axon Development Cell Communication Collateral Sprouting In Absence Of Injury	Regulation Of Immune System Process Regulation Of Immune Response Positive Regulation Of Cell Activation Immune Response Immune System Process Defense Response Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Innate Immune Response Regulation Of Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell-cell Adhesion Regulation Of Cell Adhesion Peptidyl-tyrosine Autophosphorylation Cell Activation Positive Regulation Of Cell Adhesion Regulation Of Cell Activation Leukocyte Activation Regulation Of Lymphocyte Activation T Cell Costimulation Leukocyte Cell-cell Adhesion Positive Regulation Of Immune System Process Homotypic Cell-cell Adhesion Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Leukocyte Aggregation Locomotion Lymphocyte Activation Single Organismal Cell-cell Adhesion Cell Surface Receptor Signaling Pathway T Cell Aggregation T Cell Activation Lymphocyte Aggregation Antigen Receptor-mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Signal Transduction Response To Stress Immune Response-regulating Signaling Pathway Signal Transduction Movement Of Cell Or Subcellular Component Positive Regulation Of Immune Response Cell Adhesion Signaling Response To Stimulus Regulation Of Signal Transduction Cell Communication T Cell Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Positive Regulation Of Intracellular Signal Transduction
Tagcloud ?		acaa1 analogous ap1m2 aspirates cgn combat dcn ddr1 deadly ec ecs efemp2 endometrial eps8l2 fastkd1 gmip ikbke minimally noncarcinoma p2rx4 p4hb phkg2 ppp1r16a rassf7 rnf183 sirt6 socs2 tjp3 uterine	abl adaptor bcr cd45 chemistry cief cml combines crkl describes detect example focusing isoelectric limit linking lysate nanocapillary nanogram nl pg protocol ptyr207 quantities reproducible screen throughput tkis uv
Tagcloud (Difference) ?		acaa1 analogous ap1m2 aspirates cgn combat dcn ddr1 deadly ec ecs efemp2 endometrial eps8l2 fastkd1 gmip ikbke minimally noncarcinoma p2rx4 p4hb phkg2 ppp1r16a rassf7 rnf183 sirt6 socs2 tjp3 uterine	abl adaptor bcr cd45 chemistry cief cml combines crkl describes detect example focusing isoelectric limit linking lysate nanocapillary nanogram nl pg protocol ptyr207 quantities reproducible screen throughput tkis uv
Tagcloud (Intersection) ?