PPFIBP2 and HSF4

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		PPFIBP2	HSF4
Name		PPFIB scaffold protein 2	heat shock transcription factor 4
Structure
GO Annotations	Cellular Component	Extracellular Space Cytosol Presynaptic Active Zone Presynapse	Chromatin Nucleus Nuclear Speck
	Molecular Function	Protein Binding Identical Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Phosphatase Binding Identical Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Neuromuscular Junction Development	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Lens Fiber Cell Differentiation
Pathways		Receptor-type tyrosine-protein phosphatases	None
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134 ) Blond vs. brown/black hair color ( 30531825 ) Brown vs. black hair color ( 30531825 ) Cutaneous melanoma or hair colour ( 32341527 ) Fasting glucose ( 34059833 ) Hair color ( 29662168 ) Malaria ( 31844061 ) Prostate cancer ( 26443449 29892016 ) Prostate cancer (advanced) ( 29892016 )	No GWAS studies recorded
Novel Interactors		None recorded	3 novel interactors: BBS2 CNOT1 STOML2
Interacting Genes		12 interacting genes: APP CLK1 CRK CRKL DTNB HSF4 PPFIA1 PPFIA2 PPFIA3 PRNP PTPRC TSG101	43 interacting genes: ACTMAP AKAP8L ALKBH4 C10orf55 CDK2AP2 DAXX DUSP26 FAM168B FAM200C FOXH1 FOXI1 GFOD1 HGS INTS11 KRT31 KRT37 KRT38 KRT40 KRTAP19-6 KRTAP19-7 KRTAP3-1 KRTAP6-2 MAPK1 MAPK14 MAPK3 MAPK8 MKRN3 NHLRC4 NUDT21 NUP62 OIP5 PIH1D2 PITX1 PLA2G10 PPFIBP2 SESTD1 SLC27A5 SMARCA4 SOX10 TPM3 UFSP1 YTHDF1 ZMYND12
Entrez ID		8495	3299
HPRD ID		04391	03896
Ensembl ID		ENSG00000166387	ENSG00000102878
Uniprot IDs		A0A804HJY3 A0A804HKA2 Q8ND30	Q9ULV5
PDB IDs		3QH9	6J6V 6J6W
GO Terms Enriched among Interactors		Helper T Cell Diapedesis Postsynaptic Specialization Organization Cerebellar Neuron Development Dendrite Development Regulation Of T Cell Migration Regulation Of Protein Localization To Membrane Presynaptic Active Zone Positive Regulation Of Calcium-mediated Signaling Positive Regulation Of Protein Localization Diapedesis Regulation Of Lymphocyte Migration Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Regulation Of Protein Localization Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Synapse Synapse Organization Negative Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Protein Localization To Membrane Positive Regulation Of Receptor Clustering Reelin-mediated Signaling Pathway Postsynaptic Specialization Assembly Neuron Projection Maintenance Regulation Of Dendritic Spine Maintenance Regulation Of Calcium-mediated Signaling Response To Yeast Regulation Of Cellular Component Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Intracellular Copper Ion Homeostasis Regulation Of Cell Projection Organization Regulation Of Receptor Clustering Heparan Sulfate Proteoglycan Binding Positive Regulation Of Rac Protein Signal Transduction Copper Ion Homeostasis Cellular Response To Copper Ion Regulation Of Postsynapse Organization Regulation Of Mononuclear Cell Migration Molecular Function Activator Activity Negative Regulation Of Interleukin-2 Production Ephrin Receptor Binding Positive Regulation Of Endocytosis Positive Regulation Of MAPK Cascade Cell Junction Organization Dendrite Regulation Of Rac Protein Signal Transduction Response To Copper Ion Positive Regulation Of ERK1 And ERK2 Cascade T Cell Migration Modulation Of Chemical Synaptic Transmission Regulation Of Immune Response Negative Regulation Of Transcription By RNA Polymerase II	Intermediate Filament MAP Kinase Activity Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Keratin Filament Protein Binding Structural Constituent Of Skin Epidermis Interleukin-34-mediated Signaling Pathway Positive Regulation Of Cyclase Activity Nuclear Androgen Receptor Binding Intermediate Filament Organization Regulation Of Golgi Inheritance Caveolin-mediated Endocytosis Positive Regulation Of Macrophage Proliferation Anatomical Structure Morphogenesis Intermediate Filament Cytoskeleton Organization Structural Molecule Activity Intermediate Filament-based Process Lipopolysaccharide-mediated Signaling Pathway Cardiac Neural Crest Cell Development Involved In Heart Development Trachea Formation Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Morphogenesis Of An Epithelium Outer Ear Morphogenesis ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Bergmann Glial Cell Differentiation MAPK Cascade Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Cellular Senescence Tissue Morphogenesis Cellular Response To Amino Acid Starvation Response To Amino Acid Starvation Glial Cell Development Negative Regulation Of Cholesterol Efflux Regulation Of Gene Expression P53 Binding Regulation Of Golgi Organization Pseudopodium Negative Regulation Of Androgen Receptor Signaling Pathway Positive Regulation Of Biosynthetic Process Regulation Of Early Endosome To Late Endosome Transport Schwann Cell Development Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Neuroinflammatory Response Positive Regulation Of Macrophage Chemotaxis Animal Organ Formation Negative Regulation Of Cholesterol Transport