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PPFIBP2 and CRKL
Number of citations of the paper that reports this interaction (PubMedID
21988832
)
38
Data Source:
BioGRID
(two hybrid)
PPFIBP2
CRKL
Description
PPFIB scaffold protein 2
CRK like proto-oncogene, adaptor protein
Image
GO Annotations
Cellular Component
Extracellular Space
Cytosol
Presynaptic Active Zone
Presynapse
Nucleoplasm
Cytoplasm
Cytosol
Neuromuscular Junction
Protein-containing Complex
Synapse
Extrinsic Component Of Postsynaptic Membrane
Molecular Function
Protein Binding
Identical Protein Binding
Phosphotyrosine Residue Binding
RNA Binding
Protein Binding
Receptor Tyrosine Kinase Binding
Signaling Adaptor Activity
Identical Protein Binding
Cadherin Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Biological Process
Neuromuscular Junction Development
Regulation Of Cell Growth
Blood Vessel Development
Urogenital System Development
Neuron Migration
B Cell Apoptotic Process
Regulation Of Leukocyte Migration
Outflow Tract Morphogenesis
Lipid Metabolic Process
Enzyme-linked Receptor Protein Signaling Pathway
JNK Cascade
Ras Protein Signal Transduction
Spermatogenesis
Single Fertilization
Pattern Specification Process
Heart Development
Positive Regulation Of Cell Population Proliferation
Fibroblast Growth Factor Receptor Signaling Pathway
Male Gonad Development
Animal Organ Morphogenesis
Anterior/posterior Pattern Specification
Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Dendrite Development
Cell Migration
Hippocampus Development
Cerebral Cortex Development
Establishment Of Cell Polarity
Regulation Of Cell Migration
Regulation Of Cell Adhesion Mediated By Integrin
Positive Regulation Of Rac Protein Signal Transduction
Intracellular Signal Transduction
Helper T Cell Diapedesis
Reelin-mediated Signaling Pathway
Positive Regulation Of MAPK Cascade
Retinoic Acid Receptor Signaling Pathway
Thymus Development
Regulation Of Dendrite Development
T Cell Receptor Signaling Pathway
Parathyroid Gland Development
Cell Chemotaxis
Negative Regulation Of SMAD Protein Signal Transduction
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Growth Factor Stimulus
Cellular Response To Xenobiotic Stimulus
Cellular Response To Transforming Growth Factor Beta Stimulus
Response To Fibroblast Growth Factor
Endothelin Receptor Signaling Pathway
Acetylcholine Receptor Signaling Pathway
Postsynaptic Specialization Assembly
Cerebellar Neuron Development
Cellular Response To Interleukin-7
Chordate Pharynx Development
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Positive Regulation Of Glial Cell Migration
Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering
Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering
Cranial Skeletal System Development
Regulation Of T Cell Migration
Pathways
Receptor-type tyrosine-protein phosphatases
Frs2-mediated activation
Frs2-mediated activation
Downstream signal transduction
MET activates RAP1 and RAC1
MET receptor recycling
Erythropoietin activates RAS
Erythropoietin activates RAS
Regulation of signaling by CBL
Drugs
Diseases
GWAS
3-month functional outcome in ischaemic stroke (modified Rankin score) (
30796134
)
Blond vs. brown/black hair color (
30531825
)
Brown vs. black hair color (
30531825
)
Cutaneous melanoma or hair colour (
32341527
)
Fasting glucose (
34059833
)
Hair color (
29662168
)
Malaria (
31844061
)
Prostate cancer (
26443449
29892016
)
Prostate cancer (advanced) (
29892016
)
Mean platelet volume (
32888494
)
Platelet distribution width (
27863252
32888494
)
Interacting Genes
12 interacting genes:
APP
CLK1
CRK
CRKL
DTNB
HSF4
PPFIA1
PPFIA2
PPFIA3
PRNP
PTPRC
TSG101
78 interacting genes:
ABL1
AOX1
AREL1
ARHGAP32
BCAR1
BCR
BIK
BLK
BLNK
CBL
CBLB
CD34
CRK
DAB1
DOCK2
DOK1
DOK2
EPHB6
EPOR
ERBB2
ERBB3
ETV6
EVL
FCGR1A
GAB1
GAB2
GAREM1
GRB2
GRN
IFNAR1
IGF1R
INPP5D
INSR
IRS4
ITGB1
KHDRBS1
KIDINS220
KIT
LAMA5
LTBP4
LYN
MAP4K1
MAP4K5
MEGF6
MSL1
NEDD9
NOTCH2
PDGFRA
PHC2
PIK3R1
PIK3R2
PLEKHA1
PLSCR1
POLR1D
PPFIBP2
PSMC6
PTPDC1
PTPN11
PXN
RAPGEF1
RPL31
SASH1
SHANK3
SHC1
SOS1
SOS2
STAT5A
STAT5B
SYK
TGFB1I1
TMEM168
TYK2
USP53
WAC
WAS
WIPF1
YES1
YY1
Entrez ID
8495
1399
HPRD ID
04391
03596
Ensembl ID
ENSG00000166387
ENSG00000099942
Uniprot IDs
A0A804HJY3
A0A804HKA2
Q8ND30
P46109
PDB IDs
3QH9
2BZX
2BZY
2DBK
2EO3
2LQN
2LQW
Enriched GO Terms of Interacting Partners
?
Helper T Cell Diapedesis
Postsynaptic Specialization Organization
Cerebellar Neuron Development
Dendrite Development
Regulation Of T Cell Migration
Regulation Of Protein Localization To Membrane
Presynaptic Active Zone
Positive Regulation Of Calcium-mediated Signaling
Positive Regulation Of Protein Localization
Diapedesis
Regulation Of Lymphocyte Migration
Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering
Regulation Of Protein Localization
Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering
Synapse
Synapse Organization
Negative Regulation Of Long-term Synaptic Potentiation
Positive Regulation Of Protein Localization To Membrane
Positive Regulation Of Receptor Clustering
Reelin-mediated Signaling Pathway
Postsynaptic Specialization Assembly
Neuron Projection Maintenance
Regulation Of Dendritic Spine Maintenance
Regulation Of Calcium-mediated Signaling
Response To Yeast
Regulation Of Cellular Component Organization
Regulation Of Plasma Membrane Bounded Cell Projection Organization
Intracellular Copper Ion Homeostasis
Regulation Of Cell Projection Organization
Regulation Of Receptor Clustering
Heparan Sulfate Proteoglycan Binding
Positive Regulation Of Rac Protein Signal Transduction
Copper Ion Homeostasis
Cellular Response To Copper Ion
Regulation Of Postsynapse Organization
Regulation Of Mononuclear Cell Migration
Molecular Function Activator Activity
Negative Regulation Of Interleukin-2 Production
Ephrin Receptor Binding
Positive Regulation Of Endocytosis
Positive Regulation Of MAPK Cascade
Cell Junction Organization
Dendrite
Regulation Of Rac Protein Signal Transduction
Response To Copper Ion
Positive Regulation Of ERK1 And ERK2 Cascade
T Cell Migration
Modulation Of Chemical Synaptic Transmission
Regulation Of Immune Response
Negative Regulation Of Transcription By RNA Polymerase II
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Cell Surface Receptor Signaling Pathway
Signal Transduction
SH3 Domain Binding
Phosphotyrosine Residue Binding
Intracellular Signal Transduction
Protein Tyrosine Kinase Activity
Immune System Process
Insulin Receptor Signaling Pathway
Cell Activation
Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of Immune Response
Leukocyte Activation
Immune Effector Process
ERBB Signaling Pathway
B Cell Receptor Signaling Pathway
Lymphocyte Activation
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Intracellular Signaling Cassette
Cytosol
Regulation Of Immune System Process
B Cell Differentiation
Antigen Receptor-mediated Signaling Pathway
Positive Regulation Of Immune System Process
Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity
B Cell Activation
Immune Response-activating Cell Surface Receptor Signaling Pathway
Regulation Of Signal Transduction
Regulation Of Cellular Component Organization
Positive Regulation Of MAPK Cascade
Cell Migration
Cellular Response To Growth Factor Stimulus
Plasma Membrane
Regulation Of Cell Activation
Immune Response-regulating Signaling Pathway
Protein Tyrosine Kinase Binding
Positive Regulation Of Cellular Component Organization
Regulation Of MAPK Cascade
Protein Kinase Activity
Positive Regulation Of Immune Response
Regulation Of Multicellular Organismal Process
Growth Hormone Receptor Signaling Pathway
T Cell Activation
Regulation Of Signaling
Regulation Of Cell Communication
Response To Growth Factor
Regulation Of Multicellular Organismal Development
Ephrin Receptor Binding
Regulation Of Leukocyte Proliferation
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Tagcloud (Intersection)
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