PPFIBP2 and PPFIA3

Number of citations: 0 (PubMedID 9624153)
Data Source: HPRD (in vitro)

		PPFIBP2	PPFIA3
Name		PPFIB scaffold protein 2	PPFI scaffold protein A3
Structure			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytosol Presynaptic Active Zone Presynapse	Acrosomal Vesicle Cytoplasm Cytosol Cytoplasmic Vesicle Synapse Presynaptic Active Zone Presynaptic Active Zone Cytoplasmic Component Epididymosome Glutamatergic Synapse
	Molecular Function	Protein Binding Identical Protein Binding	Protein Binding
	Biological Process	Neuromuscular Junction Development	Neurotransmitter Secretion Synaptic Vesicle Exocytosis Synaptic Vesicle Docking Regulation Of Short-term Neuronal Synaptic Plasticity Synapse Organization
Pathways		Receptor-type tyrosine-protein phosphatases	Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Receptor-type tyrosine-protein phosphatases
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134 ) Blond vs. brown/black hair color ( 30531825 ) Brown vs. black hair color ( 30531825 ) Cutaneous melanoma or hair colour ( 32341527 ) Fasting glucose ( 34059833 ) Hair color ( 29662168 ) Malaria ( 31844061 ) Prostate cancer ( 26443449 29892016 ) Prostate cancer (advanced) ( 29892016 )	Adult body size ( 32376654 ) Leukoderma in response to rhododendrol ( 32558222 )
Novel Interactors		None recorded	1 novel interactors: ATP1A3
Interacting Genes		12 interacting genes: APP CLK1 CRK CRKL DTNB HSF4 PPFIA1 PPFIA2 PPFIA3 PRNP PTPRC TSG101	17 interacting genes: CAST CBY2 CNKSR1 DISC1 ERC2 GIT1 PPFIA1 PPFIA2 PPFIBP1 PPFIBP2 PPP1R13B PTPRD PTPRF PTPRS PTPRU SORBS3 TFIP11
Entrez ID		8495	8541
HPRD ID		04391	04393
Ensembl ID		ENSG00000166387	ENSG00000177380
Uniprot IDs		A0A804HJY3 A0A804HKA2 Q8ND30	O75145
PDB IDs		3QH9	Not available
GO Terms Enriched among Interactors		Helper T Cell Diapedesis Postsynaptic Specialization Organization Cerebellar Neuron Development Dendrite Development Regulation Of T Cell Migration Regulation Of Protein Localization To Membrane Presynaptic Active Zone Positive Regulation Of Calcium-mediated Signaling Positive Regulation Of Protein Localization Diapedesis Regulation Of Lymphocyte Migration Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Regulation Of Protein Localization Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Synapse Synapse Organization Negative Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Protein Localization To Membrane Positive Regulation Of Receptor Clustering Reelin-mediated Signaling Pathway Postsynaptic Specialization Assembly Neuron Projection Maintenance Regulation Of Dendritic Spine Maintenance Regulation Of Calcium-mediated Signaling Response To Yeast Regulation Of Cellular Component Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Intracellular Copper Ion Homeostasis Regulation Of Cell Projection Organization Regulation Of Receptor Clustering Heparan Sulfate Proteoglycan Binding Positive Regulation Of Rac Protein Signal Transduction Copper Ion Homeostasis Cellular Response To Copper Ion Regulation Of Postsynapse Organization Regulation Of Mononuclear Cell Migration Molecular Function Activator Activity Negative Regulation Of Interleukin-2 Production Ephrin Receptor Binding Positive Regulation Of Endocytosis Positive Regulation Of MAPK Cascade Cell Junction Organization Dendrite Regulation Of Rac Protein Signal Transduction Response To Copper Ion Positive Regulation Of ERK1 And ERK2 Cascade T Cell Migration Modulation Of Chemical Synaptic Transmission Regulation Of Immune Response Negative Regulation Of Transcription By RNA Polymerase II	Presynaptic Active Zone Synapse Organization Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Regulation Of Dendritic Spine Development Cell Junction Organization Transmembrane Receptor Protein Tyrosine Phosphatase Activity Cell Adhesion Synaptic Membrane Adhesion Protein Tyrosine Phosphatase Activity Maintenance Of Synapse Structure Presynaptic Membrane Phosphoprotein Phosphatase Activity Regulation Of Postsynapse Organization Glutamatergic Synapse Cell Junction Maintenance Cortical Microtubule Organization Axon Presynaptic Active Zone Organization Cellular Component Maintenance Maintenance Of Postsynaptic Specialization Structure Regulation Of Cellular Component Organization Regulation Of Neuron Projection Development Presynapse Protein Dephosphorylation Regulation Of Postsynaptic Density Assembly Modulation Of Chemical Synaptic Transmission Postsynaptic Density Schaffer Collateral - CA1 Synapse GABA-ergic Synapse Presynapse Organization Postsynaptic Density Organization Regulation Of Postsynaptic Specialization Assembly Regulation Of Excitatory Synapse Assembly Peptidyl-tyrosine Dephosphorylation Regulation Of Synapse Organization Synapse Postsynaptic Specialization Organization Dephosphorylation Regulation Of Axon Regeneration Growth Cone Regulation Of Neuron Projection Regeneration Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Cell-substrate Adhesion Neuromuscular Junction Development Regulation Of Response To Wounding Cell Cortex Focal Adhesion Regulation Of Dendritic Spine Morphogenesis