RBX1 and CUL4B

Number of citations of the paper that reports this interaction (PMID 12609982)
24

Data Source:
HPRD (in vitro)

		RBX1	CUL4B
Gene Name		ring-box 1, E3 ubiquitin protein ligase	cullin 4B
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Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytosol SCF Ubiquitin Ligase Complex VCB Complex Cullin-RING Ubiquitin Ligase Complex Cul2-RING Ubiquitin Ligase Complex Cul3-RING Ubiquitin Ligase Complex Cul4A-RING E3 Ubiquitin Ligase Complex Cul4B-RING E3 Ubiquitin Ligase Complex Cul5-RING Ubiquitin Ligase Complex Cul7-RING Ubiquitin Ligase Complex	Nucleoplasm Cytoplasm Plasma Membrane Cul4B-RING E3 Ubiquitin Ligase Complex Extracellular Vesicular Exosome
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity NEDD8 Transferase Activity Ubiquitin Protein Ligase Binding Protein Complex Binding Ubiquitin-ubiquitin Ligase Activity Ubiquitin Protein Ligase Activity Cullin Family Protein Binding	Damaged DNA Binding Protein Binding Ubiquitin Protein Ligase Binding
	Biological Process	DNA Repair Protein Monoubiquitination Notch Signaling Pathway Viral Process Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Neddylation Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Hypoxia Negative Regulation Of Canonical Wnt Signaling Pathway	Ubiquitin-dependent Protein Catabolic Process Cell Cycle Histone H2A Monoubiquitination Positive Regulation Of Protein Catabolic Process UV-damage Excision Repair Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Vif-mediated degradation of APOBEC3G Signaling by NOTCH1 HD Domain Mutants in Cancer Hedgehog 'off' state misspliced GSK3beta mutants stabilize beta-catenin T41 mutants of beta-catenin aren't phosphorylated truncated APC mutants destabilize the destruction complex TCF7L2 mutants don't bind CTBP Signaling by Wnt Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Degradation of beta-catenin by the destruction complex RNF mutants show enhanced WNT signaling and proliferation AXIN mutants destabilize the destruction complex, activating WNT signaling S33 mutants of beta-catenin aren't phosphorylated Signaling by NOTCH1 in Cancer Prolactin receptor signaling truncations of AMER1 destabilize the destruction complex misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Signaling by NOTCH Host Interactions of HIV factors phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated Signaling by ERBB4 Signaling by Interleukins deletions in the AMER1 gene destabilize the destruction complex AMER1 mutants destabilize the destruction complex Signaling by NOTCH1 PEST Domain Mutants in Cancer Interleukin-1 signaling Constitutive Signaling by NOTCH1 PEST Domain Mutants Adaptive Immune System Cellular response to hypoxia Antigen processing: Ubiquitination & Proteasome degradation Regulation of Hypoxia-inducible Factor (HIF) by oxygen Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha HIV Infection APC truncation mutants have impaired AXIN binding APC truncation mutants are not K63 polyubiquitinated S37 mutants of beta-catenin aren't phosphorylated Hedgehog 'on' state Signaling by NOTCH1 XAV939 inhibits tankyrase, stabilizing AXIN Class I MHC mediated antigen processing & presentation Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling FBXW7 Mutants and NOTCH1 in Cancer Cytokine Signaling in Immune system Nuclear signaling by ERBB4 NOTCH1 Intracellular Domain Regulates Transcription TCF dependent signaling in response to WNT Signaling by Hedgehog deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Degradation of GLI1 by the proteasome degradation of DVL Signaling by WNT in cancer GLI3 is processed to GLI3R by the proteasome Degradation of GLI2 by the proteasome
Drugs
Diseases
GWAS		Crohn's disease ( 22936669)
Protein-Protein Interactions		58 interactors: APP BRCA1 CAND1 CCND1 CCNE1 CDC34 COPS6 CSNK1E CTNNB1 CUL1 CUL3 CUL4A CUL4B CUL5 CUL7 DDB1 FBXO18 FBXW8 FRZB GLMN GPS1 HAX1 HIST1H1C MAP3K7 MAPK8IP2 MKNK2 MYB NFKBIA OS9 PLK1 PML PRAME RHOBTB3 RNF126 RPS6KB1 SAMHD1 SERTAD1 SKP1 SMAD3 TAB1 TP73 TRIM27 TRIM74 UBE2D1 UBE2D2 UBE2D3 UBE2E3 UBE2G1 UBE2G2 UBE2L3 UBE2L6 UBE2M UBE2R2 VHL VPRBP VRK2 WNK1 ZAK	22 interactors: AHR APP AR CAND1 COMMD1 DCUN1D1 DCUN1D3 DCUN1D4 DCUN1D5 DDB1 DDB2 DTL ESR1 KPNA2 KPNA4 KPNB1 NEDD8 RBX1 RNF7 SALL2 SIN3A UBC
Entrez ID		9978	8450
HPRD ID		06794	02251
Ensembl ID			ENSG00000158290
Uniprot IDs		P62877	Q13620
PDB IDs		1LDJ 1LDK 1U6G 2HYE 2LGV 3DPL 3DQV 3RTR 4F52	2DO7 4A0C 4A0L 4A64
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Protein Modification By Small Protein Conjugation Cellular Protein Modification Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Regulation Of Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Cellular Protein Metabolic Process Cellular Macromolecule Catabolic Process Positive Regulation Of Cellular Protein Metabolic Process Protein Polyubiquitination Protein K48-linked Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Metabolic Process Proteasomal Protein Catabolic Process Cell Cycle Process Cellular Response To Stimulus Cell Cycle Regulation Of Cell Cycle Cell Cycle Phase Transition Positive Regulation Of Cellular Metabolic Process Regulation Of Phosphorylation Protein Monoubiquitination Cellular Response To Stress Cellular Metabolic Process Response To Stress Regulation Of Mitotic Cell Cycle Regulation Of Phosphorus Metabolic Process Mitotic Cell Cycle Phase Transition Positive Regulation Of Protein Modification Process Proteolysis Regulation Of Protein Phosphorylation Mitotic Cell Cycle Process G1/S Transition Of Mitotic Cell Cycle Catabolic Process Response To Stimulus Positive Regulation Of Metabolic Process Mitotic Cell Cycle Negative Regulation Of Cell Cycle Regulation Of Cell Cycle Process Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Protein Kinase Activity Signal Transduction Cell Death Regulation Of Cell Cycle Phase Transition Death	Protein Modification By Small Protein Conjugation Protein Monoubiquitination Protein Neddylation Protein Ubiquitination Intracellular Receptor Signaling Pathway NLS-bearing Protein Import Into Nucleus Regulation Of Transcription From RNA Polymerase II Promoter DNA Metabolic Process Positive Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Response To UV Cellular Macromolecule Catabolic Process Response To Light Stimulus Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly UV-damage Excision Repair Positive Regulation Of Transcription From RNA Polymerase II Promoter Prostate Gland Development Response To Abiotic Stimulus Nucleobase-containing Compound Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Response To Radiation Regulation Of Cell Cycle Phase Transition Histone H2A Monoubiquitination Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter Modification-dependent Protein Catabolic Process Cellular Response To Stimulus Histone H2A Ubiquitination Cellular Nitrogen Compound Metabolic Process Positive Regulation Of DNA-templated Transcription, Initiation Viral Process Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Transcription, DNA-templated Cellular Protein Catabolic Process Nucleotide-excision Repair, DNA Damage Removal Cellular Response To Organic Substance Rhythmic Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Import Into Nucleus Histone Monoubiquitination DNA Repair Nuclear Import Regulation Of DNA-templated Transcription, Initiation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein Catabolic Process Copper Ion Homeostasis Regulation Of Apoptotic Process
Tagcloud ?		adrenal arise bc chromaffin cnl copy cul2 disrupting elongin enrichment harbored heterozygosity hif1 hif1a hippel hypoxic indeed inherited lindau merit normoxic pcc pheochromocytomas predisposing pseudohypoxic tceb1 tceb2 vhl von	absent alleviate assemble augmented blunted dampening depleted downregulated drives driving e3 ectopic exacerbate feedback greatly h2o2 ligases loop mildly negatively nhfs oxidative proteosomal replicative ros senescence senescent stressed ubiquitination
Tagcloud (Difference) ?		adrenal arise bc chromaffin cnl copy cul2 disrupting elongin enrichment harbored heterozygosity hif1 hif1a hippel hypoxic indeed inherited lindau merit normoxic pcc pheochromocytomas predisposing pseudohypoxic tceb1 tceb2 vhl von	absent alleviate assemble augmented blunted dampening depleted downregulated drives driving e3 ectopic exacerbate feedback greatly h2o2 ligases loop mildly negatively nhfs oxidative proteosomal replicative ros senescence senescent stressed ubiquitination
Tagcloud (Intersection) ?