RBX1 and RPS6KB1

Number of citations of the paper that reports this interaction (PMID 18279656)
4

Data Source:
BioGRID (pull down, affinity chromatography technology)

		RBX1	RPS6KB1
Gene Name		ring-box 1, E3 ubiquitin protein ligase	ribosomal protein S6 kinase, 70kDa, polypeptide 1
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Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytosol SCF Ubiquitin Ligase Complex VCB Complex Cullin-RING Ubiquitin Ligase Complex Cul2-RING Ubiquitin Ligase Complex Cul3-RING Ubiquitin Ligase Complex Cul4A-RING E3 Ubiquitin Ligase Complex Cul4B-RING E3 Ubiquitin Ligase Complex Cul5-RING Ubiquitin Ligase Complex Cul7-RING Ubiquitin Ligase Complex	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Cell Surface Cell Junction Neuron Projection Synapse Perinuclear Region Of Cytoplasm
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity NEDD8 Transferase Activity Ubiquitin Protein Ligase Binding Protein Complex Binding Ubiquitin-ubiquitin Ligase Activity Ubiquitin Protein Ligase Activity Cullin Family Protein Binding	Protein Kinase Activity Ribosomal Protein S6 Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Peptide Binding
	Biological Process	DNA Repair Protein Monoubiquitination Notch Signaling Pathway Viral Process Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Neddylation Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Hypoxia Negative Regulation Of Canonical Wnt Signaling Pathway	G1/S Transition Of Mitotic Cell Cycle Skeletal Muscle Contraction Protein Phosphorylation Apoptotic Process Signal Transduction Germ Cell Development Aging Response To Nutrient Long-term Memory Insulin Receptor Signaling Pathway Response To Heat Response To Wounding Response To Mechanical Stimulus Response To Toxic Substance Response To Glucose Skeletal Muscle Atrophy Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Positive Regulation Of Smooth Muscle Cell Migration Cell Migration TOR Signaling Response To Lipopolysaccharide Response To Testosterone Response To Glucagon Response To Tumor Necrosis Factor Response To Drug Negative Regulation Of Apoptotic Process Response To Leucine Protein Kinase B Signaling Response To Ethanol Positive Regulation Of Translation Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Translational Initiation Regulation Of Glucose Import Negative Regulation Of Insulin Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Skeletal Muscle Tissue Growth Positive Regulation Of Smooth Muscle Cell Proliferation Response To Glucocorticoid Cellular Response To Growth Factor Stimulus Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Vif-mediated degradation of APOBEC3G Signaling by NOTCH1 HD Domain Mutants in Cancer Hedgehog 'off' state misspliced GSK3beta mutants stabilize beta-catenin T41 mutants of beta-catenin aren't phosphorylated truncated APC mutants destabilize the destruction complex TCF7L2 mutants don't bind CTBP Signaling by Wnt Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Degradation of beta-catenin by the destruction complex RNF mutants show enhanced WNT signaling and proliferation AXIN mutants destabilize the destruction complex, activating WNT signaling S33 mutants of beta-catenin aren't phosphorylated Signaling by NOTCH1 in Cancer Prolactin receptor signaling truncations of AMER1 destabilize the destruction complex misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Signaling by NOTCH Host Interactions of HIV factors phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated Signaling by ERBB4 Signaling by Interleukins deletions in the AMER1 gene destabilize the destruction complex AMER1 mutants destabilize the destruction complex Signaling by NOTCH1 PEST Domain Mutants in Cancer Interleukin-1 signaling Constitutive Signaling by NOTCH1 PEST Domain Mutants Adaptive Immune System Cellular response to hypoxia Antigen processing: Ubiquitination & Proteasome degradation Regulation of Hypoxia-inducible Factor (HIF) by oxygen Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha HIV Infection APC truncation mutants have impaired AXIN binding APC truncation mutants are not K63 polyubiquitinated S37 mutants of beta-catenin aren't phosphorylated Hedgehog 'on' state Signaling by NOTCH1 XAV939 inhibits tankyrase, stabilizing AXIN Class I MHC mediated antigen processing & presentation Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling FBXW7 Mutants and NOTCH1 in Cancer Cytokine Signaling in Immune system Nuclear signaling by ERBB4 NOTCH1 Intracellular Domain Regulates Transcription TCF dependent signaling in response to WNT Signaling by Hedgehog deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Degradation of GLI1 by the proteasome degradation of DVL Signaling by WNT in cancer GLI3 is processed to GLI3R by the proteasome Degradation of GLI2 by the proteasome	Insulin receptor signalling cascade IRS-mediated signalling mTOR signalling S6K1 signalling S6K1-mediated signalling IRS-related events mTOR signalling mTORC1-mediated signalling IGF1R signaling cascade S6K1-mediated signalling mTORC1-mediated signalling IRS-related events triggered by IGF1R IRS-mediated signalling S6K1 signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PKB-mediated events PKB-mediated events PI3K Cascade PI3K Cascade Signaling by Insulin receptor
Drugs
Diseases
GWAS		Crohn's disease ( 22936669)	Inflammatory bowel disease ( 23128233) Multiple sclerosis ( 21833088) Obesity-related traits ( 23251661)
Protein-Protein Interactions		58 interactors: APP BRCA1 CAND1 CCND1 CCNE1 CDC34 COPS6 CSNK1E CTNNB1 CUL1 CUL3 CUL4A CUL4B CUL5 CUL7 DDB1 FBXO18 FBXW8 FRZB GLMN GPS1 HAX1 HIST1H1C MAP3K7 MAPK8IP2 MKNK2 MYB NFKBIA OS9 PLK1 PML PRAME RHOBTB3 RNF126 RPS6KB1 SAMHD1 SERTAD1 SKP1 SMAD3 TAB1 TP73 TRIM27 TRIM74 UBE2D1 UBE2D2 UBE2D3 UBE2E3 UBE2G1 UBE2G2 UBE2L3 UBE2L6 UBE2M UBE2R2 VHL VPRBP VRK2 WNK1 ZAK	54 interactors: ACTA1 AKT1 APP BTK CDC42 CDK1 CLEC3B COASY CSNK2A1 CSNK2B DPPA4 EEF2K EIF4B EIF4EBP1 EP300 GDI2P1 HTT IRS1 KAT2B KIR3DL1 LYN MAPK1 MAPK3 MAPK8 MAPK9 MAPT MLST8 MTOR MXD1 NCBP1 NEDD4 NEK6 NR1I2 PDK1 PDPK1 PIK3CA PIN1 POLDIP3 PPP1R9A PPP1R9B PPP2CA RAC1 RBX1 RHEB RICTOR RPS6 RPTOR SRC STK11 SYK TERT TRAF4 URI1 XPO1
Entrez ID		9978	6198
HPRD ID		06794	10202
Ensembl ID			ENSG00000108443
Uniprot IDs		P62877	B2R779 B4DLT4 B4DTG1 F6UYM1 P23443 Q7Z721
PDB IDs		1LDJ 1LDK 1U6G 2HYE 2LGV 3DPL 3DQV 3RTR 4F52	3A60 3A61 3A62 4L3J 4L3L 4L42 4L43 4L44 4L45 4L46
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Protein Modification By Small Protein Conjugation Cellular Protein Modification Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Regulation Of Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Cellular Protein Metabolic Process Cellular Macromolecule Catabolic Process Positive Regulation Of Cellular Protein Metabolic Process Protein Polyubiquitination Protein K48-linked Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Metabolic Process Proteasomal Protein Catabolic Process Cell Cycle Process Cellular Response To Stimulus Cell Cycle Regulation Of Cell Cycle Cell Cycle Phase Transition Positive Regulation Of Cellular Metabolic Process Regulation Of Phosphorylation Protein Monoubiquitination Cellular Response To Stress Cellular Metabolic Process Response To Stress Regulation Of Mitotic Cell Cycle Regulation Of Phosphorus Metabolic Process Mitotic Cell Cycle Phase Transition Positive Regulation Of Protein Modification Process Proteolysis Regulation Of Protein Phosphorylation Mitotic Cell Cycle Process G1/S Transition Of Mitotic Cell Cycle Catabolic Process Response To Stimulus Positive Regulation Of Metabolic Process Mitotic Cell Cycle Negative Regulation Of Cell Cycle Regulation Of Cell Cycle Process Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Protein Kinase Activity Signal Transduction Cell Death Regulation Of Cell Cycle Phase Transition Death	Cellular Response To Organic Substance Response To Organic Substance Regulation Of Protein Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Insulin Stimulus Response To Insulin Insulin Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Peptide Hormone Stimulus Regulation Of Cellular Protein Metabolic Process Cellular Response To Peptide Cellular Response To Organonitrogen Compound Fc Receptor Signaling Pathway Cellular Response To Hormone Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Response To Hormone Fc-epsilon Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Protein Phosphorylation Response To Peptide Hormone Positive Regulation Of Protein Metabolic Process Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Response To Peptide Regulation Of Signal Transduction Regulation Of Phosphorylation Cellular Response To Stimulus Positive Regulation Of Protein Phosphorylation Response To Organonitrogen Compound Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Phosphorylation Signal Transduction Regulation Of Signaling Innate Immune Response Intracellular Signal Transduction Signaling Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Signal Transduction Cell Communication Immune Response Positive Regulation Of Protein Modification Process Regulation Of Kinase Activity Regulation Of Metabolic Process Cellular Response To Growth Factor Stimulus Positive Regulation Of Metabolic Process T Cell Costimulation Response To Growth Factor Neurotrophin TRK Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway
Tagcloud ?		adrenal arise bc chromaffin cnl copy cul2 disrupting elongin enrichment harbored heterozygosity hif1 hif1a hippel hypoxic indeed inherited lindau merit normoxic pcc pheochromocytomas predisposing pseudohypoxic tceb1 tceb2 vhl von	70kda ablation amp ampk aortas apoe apolipoprotein arg2 arginase atherogenesis atherosclerosis atherosclerotic autophagy crosstalk h160f impairs interested mtorc1 mtorc2 nonsenescent polypeptide prkaa replicative rictor s6k1 senescent ureahydrolase wk
Tagcloud (Difference) ?		adrenal arise bc chromaffin cnl copy cul2 disrupting elongin enrichment harbored heterozygosity hif1 hif1a hippel hypoxic indeed inherited lindau merit normoxic pcc pheochromocytomas predisposing pseudohypoxic tceb1 tceb2 vhl von	70kda ablation amp ampk aortas apoe apolipoprotein arg2 arginase atherogenesis atherosclerosis atherosclerotic autophagy crosstalk h160f impairs interested mtorc1 mtorc2 nonsenescent polypeptide prkaa replicative rictor s6k1 senescent ureahydrolase wk
Tagcloud (Intersection) ?