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RBX1 and CSNK1E
Number of citations of the paper that reports this interaction (PubMedID
21900206
)
0
Data Source:
BioGRID
(two hybrid)
RBX1
CSNK1E
Description
ring-box 1
casein kinase 1 epsilon
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
SCF Ubiquitin Ligase Complex
VCB Complex
Cullin-RING Ubiquitin Ligase Complex
Cul2-RING Ubiquitin Ligase Complex
Cul3-RING Ubiquitin Ligase Complex
Cul4A-RING E3 Ubiquitin Ligase Complex
Cul4B-RING E3 Ubiquitin Ligase Complex
Cul5-RING Ubiquitin Ligase Complex
Cul7-RING Ubiquitin Ligase Complex
Cul4-RING E3 Ubiquitin Ligase Complex
Site Of DNA Damage
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Growth Cone
Neuronal Cell Body
Ribonucleoprotein Complex
Molecular Function
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Transferase Activity
NEDD8 Transferase Activity
Ubiquitin Protein Ligase Binding
Ubiquitin-ubiquitin Ligase Activity
Protein-containing Complex Binding
Metal Ion Binding
Molecular Adaptor Activity
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Ubiquitin Protein Ligase Activity
NEDD8 Ligase Activity
Cullin Family Protein Binding
Nucleotide Binding
RNA Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Protein Serine Kinase Activity
Biological Process
Autophagosome Assembly
G1/S Transition Of Mitotic Cell Cycle
MAPK Cascade
Protein Polyubiquitination
Mitophagy
Epithelial To Mesenchymal Transition
DNA Repair
Transcription-coupled Nucleotide-excision Repair
Transcription By RNA Polymerase II
Transcription Elongation By RNA Polymerase II
Ubiquitin-dependent Protein Catabolic Process
Protein Monoubiquitination
Apoptotic Process
DNA Damage Response
Response To Oxidative Stress
Lysosome Organization
Spermatogenesis
Regulation Of Mitotic Cell Cycle
Insulin Receptor Signaling Pathway
Negative Regulation Of Autophagy
Positive Regulation Of Autophagy
Protein Ubiquitination
Cytokine-mediated Signaling Pathway
Protein Catabolic Process
DNA Damage Response, Signal Transduction By P53 Class Mediator
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Cellular Response To Nutrient Levels
Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Type I Interferon Production
Positive Regulation Of Type I Interferon Production
Cellular Response To Insulin Stimulus
Cellular Response To Amino Acid Starvation
Cellular Response To Oxidative Stress
Cellular Response To UV
MiRNA-mediated Gene Silencing By MRNA Destabilization
P38MAPK Cascade
TORC1 Signaling
T Cell Activation
Signal Transduction In Response To DNA Damage
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Post-translational Protein Modification
Protein Neddylation
Positive Regulation Of Translation
Positive Regulation Of Protein Catabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Insulin Receptor Signaling Pathway
Type I Interferon-mediated Signaling Pathway
Cellular Response To Chemical Stress
Renal Sodium Ion Absorption
Protein K48-linked Ubiquitination
Cellular Response To Amino Acid Stimulus
Negative Regulation Of Canonical Wnt Signaling Pathway
Base-excision Repair, AP Site Formation Via Deaminated Base Removal
Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway
RNA Polymerase II Transcription Initiation Surveillance
Regulation Of Cellular Response To Insulin Stimulus
Negative Regulation Of Mitophagy
Negative Regulation Of Signal Transduction By P53 Class Mediator
Positive Regulation Of Protein Autoubiquitination
Negative Regulation Of Response To Oxidative Stress
Positive Regulation Of Epithelial Cell Apoptotic Process
Negative Regulation Of TORC1 Signaling
Positive Regulation Of TORC1 Signaling
Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
DNA Repair
Protein Phosphorylation
Endocytosis
Signal Transduction
Intracellular Protein Localization
Regulation Of Wnt Signaling Pathway
Positive Regulation Of Wnt Signaling Pathway
Negative Regulation Of Wnt Signaling Pathway
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Protein Localization
Circadian Regulation Of Gene Expression
Non-canonical Wnt Signaling Pathway
Regulation Of Circadian Rhythm
Rhythmic Process
Circadian Behavior
Negative Regulation Of Small GTPase Mediated Signal Transduction
Canonical Wnt Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Amyloid-beta Formation
Cellular Response To Nerve Growth Factor Stimulus
Positive Regulation Of Non-canonical Wnt Signaling Pathway
Pathways
Recognition of DNA damage by PCNA-containing replication complex
Prolactin receptor signaling
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Vif-mediated degradation of APOBEC3G
Degradation of beta-catenin by the destruction complex
NOTCH1 Intracellular Domain Regulates Transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Degradation of DVL
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'on' state
Regulation of RAS by GAPs
DNA Damage Recognition in GG-NER
Formation of Incision Complex in GG-NER
Dual Incision in GG-NER
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Orc1 removal from chromatin
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
Regulation of RUNX2 expression and activity
Neddylation
Regulation of expression of SLITs and ROBOs
Interleukin-1 signaling
Negative regulation of NOTCH4 signaling
Potential therapeutics for SARS
Regulation of BACH1 activity
Nuclear events stimulated by ALK signaling in cancer
KEAP1-NFE2L2 pathway
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2
Antigen processing: Ubiquitination & Proteasome degradation
Evasion by RSV of host interferon responses
GSK3B-mediated proteasomal degradation of PD-L1(CD274)
SPOP-mediated proteasomal degradation of PD-L1(CD274)
Degradation of CRY and PER proteins
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
WNT mediated activation of DVL
Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
Major pathway of rRNA processing in the nucleolus and cytosol
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A
AURKA Activation by TPX2
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex
Drugs
Seliciclib
Umbralisib
Diseases
GWAS
Alcohol use disorder (consumption score) (
30940813
)
Allergic rhinitis (
25085501
)
Autism spectrum disorder or schizophrenia (
28540026
)
Bipolar disorder (
31043756
)
Bipolar I disorder (
31043756
)
Crohn's disease (
22936669
)
LDL cholesterol levels (
32203549
)
Neuroticism (
29255261
)
Refractive error (
32231278
)
Keratoconus (
31855235
)
Mastocytosis (
32752121
)
Interacting Genes
78 interacting genes:
APP
ARIH1
ARIH2
CAND1
CAND2
CCND1
CCNK
CDC34
CFLAR
COPS4
COPS6
CSNK1E
CUL1
CUL3
CUL4A
CUL4B
CUL5
CUL7
ELOB
ELOC
ERBIN
ERCC8
FBH1
FBXL2
FBXO45
FBXW8
FRZB
GHR
GLMN
GPS1
HAX1
KCTD17
KEAP1
KLHDC2
KLHL22
KLHL3
KPNB1
KRTAP12-2
MAGEC2
MAP3K20
MAP3K7
MAPK8IP2
MKNK2
MYB
NEURL2
OS9
PBX4
PML
PRAME
RHOBTB3
RNF126
RPS6KB1
SERTAD1
SKP1
SMAD3
SNAI1
TAB1
TRIM27
TRIM74
UBE2C
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E2
UBE2E3
UBE2F
UBE2G1
UBE2G2
UBE2H
UBE2L3
UBE2L6
UBE2M
UBE2N
UBE2R2
VHL
VRK2
61 interacting genes:
AKAP17A
AKAP9
ANKRD6
APC
APP
ARHGEF1
AXIN1
AXIN2
BBS10
BHLHE41
BID
BMAL1
CADM4
CCDC14
CLOCK
CRY1
CSNK2B
DELEC1
DVL1
DVL2
DVL3
ENTR1
FAM110A
FAM110C
FAM83D
FBP1
FBXO7
FBXW11
GTF3C1
HAUS7
HES1
KAT7
NCOA3
NR1D2
PER1
PER2
PER3
PPP1CA
PPP1CC
PPP1R14A
PPP2R5D
PPP2R5E
PTPRD
RAD17
RAD54B
RBX1
RORA
RORC
SNCA
SOCS3
TAFAZZIN
TAOK1
TLE5
TNS2
TRIM2
TRIM3
WDCP
YAP1
ZMYND8
ZNF227
ZNF618
Entrez ID
9978
1454
HPRD ID
06794
02919
Ensembl ID
ENSG00000100387
ENSG00000213923
Uniprot IDs
P62877
P49674
Q5U045
PDB IDs
1LDJ
1LDK
1U6G
2HYE
2LGV
3DPL
3DQV
3RTR
4F52
4P5O
5N4W
6R6H
6R7F
6R7H
6R7I
6R7N
6TTU
7B5L
7B5M
7B5N
7B5S
7OKQ
7PLO
7Z8B
7Z8R
7Z8T
7Z8V
7ZBW
7ZBZ
8B3G
8B3I
8CDJ
8CDK
8GQ6
8H33
8H34
8H35
8H36
8H37
8H38
8H3A
8H3F
8H3Q
8H3R
8IJ1
8JAQ
8JAS
8JAV
8JE1
8K9I
8KHP
8OR0
8OR2
8OR3
8OR4
8PQL
8Q7E
8Q7H
8Q7R
8QU8
8R5H
8RHZ
8RWZ
8RX0
8UBU
8WDK
8WQA
8WQB
8WQC
8WQE
8WQF
8WQG
8WQH
9JKB
9KBD
4HNI
4HOK
Enriched GO Terms of Interacting Partners
?
Protein Modification By Small Protein Conjugation
Post-translational Protein Modification
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Protein Ubiquitination
Protein Modification Process
Proteolysis Involved In Protein Catabolic Process
Macromolecule Catabolic Process
Protein Metabolic Process
Proteasomal Protein Catabolic Process
Proteolysis
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Protein Polyubiquitination
Protein K48-linked Ubiquitination
Protein Catabolic Process
Ubiquitin Conjugating Enzyme Activity
Catabolic Process
Ubiquitin-protein Transferase Activity
Macromolecule Metabolic Process
Cullin-RING Ubiquitin Ligase Complex
Protein Monoubiquitination
Cytosol
Ubiquitin-like Ligase-substrate Adaptor Activity
Ubiquitin Protein Ligase Binding
Ubiquitin Ligase Complex Scaffold Activity
Nucleus
Protein K11-linked Ubiquitination
Regulation Of Protein Metabolic Process
Cul2-RING Ubiquitin Ligase Complex
G1/S Transition Of Mitotic Cell Cycle
Cellular Response To Stress
Ubiquitin-like Protein Transferase Activity
Cell Cycle G1/S Phase Transition
Cell Cycle Phase Transition
Transferase Activity
SCF Ubiquitin Ligase Complex
Nucleoplasm
Cytoplasm
Response To Stress
Protein K63-linked Ubiquitination
Mitotic Cell Cycle Phase Transition
Ubiquitin Ligase Complex
Cul4A-RING E3 Ubiquitin Ligase Complex
ATP Binding
Cul3-RING Ubiquitin Ligase Complex
Protein Binding
Regulation Of Intracellular Signal Transduction
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of TORC1 Signaling
Circadian Regulation Of Gene Expression
Regulation Of Circadian Rhythm
Circadian Rhythm
Regulation Of Signal Transduction
Rhythmic Process
Photoperiodism
Regulation Of Cell Communication
Regulation Of Signaling
Entrainment Of Circadian Clock By Photoperiod
Negative Regulation Of Signal Transduction
Entrainment Of Circadian Clock
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Response To Radiation
Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway
Positive Regulation Of Circadian Rhythm
Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Wnt Signaling Pathway
Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of RNA Metabolic Process
E-box Binding
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Regulation Of Cell Cycle
Response To Light Stimulus
Regulation Of Wnt Signaling Pathway
Regulation Of Primary Metabolic Process
Cytoplasm
Signal Transduction
Regulation Of Fat Cell Differentiation
Intracellular Signal Transduction
Negative Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Intracellular Signal Transduction
Transcription Corepressor Binding
Proteasomal Protein Catabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Cell Differentiation
Canonical Wnt Signaling Pathway
Beta-catenin Binding
Positive Regulation Of Neuron Projection Arborization
Negative Regulation Of Wnt Signaling Pathway
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of DNA-templated Transcription
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