RBX1 and CCND1

Number of citations of the paper that reports this interaction (PubMedID 11311237)
0

Data Source:
HPRD (in vivo)

		RBX1	CCND1
Description		ring-box 1	cyclin D1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol SCF Ubiquitin Ligase Complex VCB Complex Cullin-RING Ubiquitin Ligase Complex Cul2-RING Ubiquitin Ligase Complex Cul3-RING Ubiquitin Ligase Complex Cul4A-RING E3 Ubiquitin Ligase Complex Cul4B-RING E3 Ubiquitin Ligase Complex Cul5-RING Ubiquitin Ligase Complex Cul7-RING Ubiquitin Ligase Complex Cul4-RING E3 Ubiquitin Ligase Complex Site Of DNA Damage	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Nucleoplasm Cytoplasm Microtubule Organizing Center Cytosol Bicellular Tight Junction Membrane Transcription Repressor Complex Nuclear Membrane Cyclin D1-CDK4 Complex Cyclin D1-CDK6 Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity NEDD8 Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin-ubiquitin Ligase Activity Protein-containing Complex Binding Metal Ion Binding Molecular Adaptor Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Ubiquitin Protein Ligase Activity NEDD8 Ligase Activity Cullin Family Protein Binding	Transcription Corepressor Activity Protein Kinase Activity Protein Binding Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Enzyme Binding Protein Kinase Binding Histone Deacetylase Binding Protein Serine/threonine Kinase Activator Activity Protein-containing Complex Binding Cyclin-dependent Protein Serine/threonine Kinase Activator Activity Proline-rich Region Binding
	Biological Process	Autophagosome Assembly G1/S Transition Of Mitotic Cell Cycle MAPK Cascade Protein Polyubiquitination Mitophagy Epithelial To Mesenchymal Transition DNA Repair Transcription-coupled Nucleotide-excision Repair Transcription By RNA Polymerase II Transcription Elongation By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Apoptotic Process DNA Damage Response Response To Oxidative Stress Lysosome Organization Spermatogenesis Regulation Of Mitotic Cell Cycle Insulin Receptor Signaling Pathway Negative Regulation Of Autophagy Positive Regulation Of Autophagy Protein Ubiquitination Cytokine-mediated Signaling Pathway Protein Catabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Nutrient Levels Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Cellular Response To Insulin Stimulus Cellular Response To Amino Acid Starvation Cellular Response To Oxidative Stress Cellular Response To UV MiRNA-mediated Gene Silencing By MRNA Destabilization P38MAPK Cascade TORC1 Signaling T Cell Activation Signal Transduction In Response To DNA Damage Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Protein Neddylation Positive Regulation Of Translation Positive Regulation Of Protein Catabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Insulin Receptor Signaling Pathway Type I Interferon-mediated Signaling Pathway Cellular Response To Chemical Stress Renal Sodium Ion Absorption Protein K48-linked Ubiquitination Cellular Response To Amino Acid Stimulus Negative Regulation Of Canonical Wnt Signaling Pathway Base-excision Repair, AP Site Formation Via Deaminated Base Removal Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway RNA Polymerase II Transcription Initiation Surveillance Regulation Of Cellular Response To Insulin Stimulus Negative Regulation Of Mitophagy Negative Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Protein Autoubiquitination Negative Regulation Of Response To Oxidative Stress Positive Regulation Of Epithelial Cell Apoptotic Process Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process	G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Re-entry Into Mitotic Cell Cycle Liver Development DNA Damage Response Lactation Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Response To Iron Ion Response To X-ray Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Wnt Signaling Pathway Neuron Differentiation Negative Regulation Of Epithelial Cell Differentiation Endoplasmic Reticulum Unfolded Protein Response Animal Organ Regeneration Mitotic G1 DNA Damage Checkpoint Signaling Response To Magnesium Ion Response To Estradiol Response To Vitamin E Leydig Cell Differentiation Mammary Gland Epithelial Cell Proliferation Positive Regulation Of Mammary Gland Epithelial Cell Proliferation Negative Regulation Of Neuron Apoptotic Process Response To Estrogen Response To Leptin Fat Cell Differentiation Response To Ethanol Response To Steroid Hormone Cell Division Response To Glucocorticoid Response To Corticosterone Response To Calcium Ion Regulation Of Cell Cycle Mammary Gland Alveolus Development Response To UV-A Liver Regeneration Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Recognition of DNA damage by PCNA-containing replication complex Prolactin receptor signaling Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Vif-mediated degradation of APOBEC3G Degradation of beta-catenin by the destruction complex NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Degradation of DVL Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Dual Incision in GG-NER Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Orc1 removal from chromatin Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A FBXL7 down-regulates AURKA during mitotic entry and in early mitosis Regulation of RUNX2 expression and activity Neddylation Regulation of expression of SLITs and ROBOs Interleukin-1 signaling Negative regulation of NOTCH4 signaling Potential therapeutics for SARS Regulation of BACH1 activity Nuclear events stimulated by ALK signaling in cancer KEAP1-NFE2L2 pathway GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 Antigen processing: Ubiquitination & Proteasome degradation Evasion by RSV of host interferon responses GSK3B-mediated proteasomal degradation of PD-L1(CD274) SPOP-mediated proteasomal degradation of PD-L1(CD274) Degradation of CRY and PER proteins Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	SCF(Skp2)-mediated degradation of p27/p21 Pre-NOTCH Transcription and Translation RMTs methylate histone arginines Interleukin-4 and Interleukin-13 signaling Cyclin D associated events in G1 Ubiquitin-dependent degradation of Cyclin D Ubiquitin-dependent degradation of Cyclin D PTK6 Regulates Cell Cycle Transcriptional Regulation by VENTX Transcriptional regulation by RUNX2 Regulation of RUNX1 Expression and Activity RUNX3 regulates WNT signaling RUNX3 regulates p14-ARF Estrogen-dependent gene expression Estrogen-dependent nuclear events downstream of ESR-membrane signaling Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) Drug-mediated inhibition of CDK4/CDK6 activity Regulation of MITF-M-dependent genes involved in cell cycle and proliferation SPOP-mediated proteasomal degradation of PD-L1(CD274)
Drugs			Acetylsalicylic acid Arsenic trioxide Encorafenib Bryostatin 1
Diseases			Breast cancer Hairy-cell leukemia Oral cancer Multiple myeloma Laryngeal cancer von Hippel-Lindau syndrome Esophageal cancer
GWAS		Alcohol use disorder (consumption score) ( 30940813) Allergic rhinitis ( 25085501) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Crohn's disease ( 22936669) LDL cholesterol levels ( 32203549) Neuroticism ( 29255261) Refractive error ( 32231278)	Adult body size ( 32376654) Birth weight ( 31043758) Blond vs. brown/black hair color ( 30531825) Body fat distribution (arm fat ratio) ( 30664634) Breast cancer ( 20453838 29059683) Breast cancer (early onset) ( 24493630) Breast size ( 22747683 27182965) Cerebral microbleeds ( 32913026) Craniofacial microsomia ( 26853712) Cutaneous malignant melanoma ( 26237428 32341527) Diastolic blood pressure ( 27841878) Height ( 25429064) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Idiopathic dilated cardiomyopathy ( 29495422) Immunoglobulin light chain (AL) amyloidosis ( 28025584) Melanoma ( 28212542) Multiple myeloma (IgH translocation) ( 23502783) Nevus count or cutaneous melanoma ( 30429480 32341527) Offspring birth weight ( 31043758) Refractive error ( 32231278) Total body bone mineral density ( 29304378) Type 2 diabetes ( 32499647 30718926 30297969) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 32888494)
Interacting Genes		78 interacting genes: APP ARIH1 ARIH2 CAND1 CAND2 CCND1 CCNK CDC34 CFLAR COPS4 COPS6 CSNK1E CUL1 CUL3 CUL4A CUL4B CUL5 CUL7 ELOB ELOC ERBIN ERCC8 FBH1 FBXL2 FBXO45 FBXW8 FRZB GHR GLMN GPS1 HAX1 KCTD17 KEAP1 KLHDC2 KLHL22 KLHL3 KPNB1 KRTAP12-2 MAGEC2 MAP3K20 MAP3K7 MAPK8IP2 MKNK2 MYB NEURL2 OS9 PBX4 PML PRAME RHOBTB3 RNF126 RPS6KB1 SERTAD1 SKP1 SMAD3 SNAI1 TAB1 TRIM27 TRIM74 UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2F UBE2G1 UBE2G2 UBE2H UBE2L3 UBE2L6 UBE2M UBE2N UBE2R2 VHL VRK2	82 interacting genes: AKAP8 AMBRA1 AR ARID4A ATF2 BCAS3 BRCA1 BRCA2 BRINP1 BTRC CALM1 CAMK1 CCNDBP1 CDC14B CDH13 CDK4 CDK6 CDK8 CDKN1A CDKN1B CRYAB CTNNB1 CUL3 DMTF1 DZIP3 EP300 ESR1 FANCC FBXO31 FBXO4 FOS GSK3B HDAC3 HERC5 IFI27 IGFBP3 INSM1 JUN JUND KAT2B KLK7 KLK9 LPL MAPK11 MCM10 MCM7 MYBL2 NCOA1 NCOA3 NPDC1 ORC4 PCNA POLR1B PPP3R2 PRKACA PRKN RABEP1 RAD51 RANBP9 RB1 RBL1 RBL2 RBX1 RFC1 RUNX1 SMAD1 SP1 STAT3 TAF1 TBC1D2 TDRD7 THRA THRB TP73 TRMO TSC2 TSTD2 UBTF UHRF2 USP13 XPO1 ZNF510
Entrez ID		9978	595
HPRD ID		06794	01346
Ensembl ID		ENSG00000100387	ENSG00000110092
Uniprot IDs		P62877	P24385 Q6FI00
PDB IDs		1LDJ 1LDK 1U6G 2HYE 2LGV 3DPL 3DQV 3RTR 4F52 4P5O 5N4W 6R6H 6R7F 6R7H 6R7I 6R7N 6TTU 7B5L 7B5M 7B5N 7B5S 7OKQ 7PLO 7Z8B 7Z8R 7Z8T 7Z8V 7ZBW 7ZBZ 8B3G 8B3I 8CDJ 8CDK 8GQ6 8H33 8H34 8H35 8H36 8H37 8H38 8H3A 8H3F 8H3Q 8H3R 8IJ1 8JAQ 8JAS 8JAV 8JE1 8K9I 8KHP 8OR0 8OR2 8OR3 8OR4 8PQL 8Q7E 8Q7H 8Q7R 8QU8 8R5H 8RHZ 8RWZ 8RX0 8UBU 8WDK 8WQA 8WQB 8WQC 8WQE 8WQF 8WQG 8WQH 9JKB 9KBD	2W96 2W99 2W9F 2W9Z 5VZU 6P8E 6P8F 6P8G 6P8H
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Conjugation Post-translational Protein Modification Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Ubiquitination Protein Modification Process Proteolysis Involved In Protein Catabolic Process Macromolecule Catabolic Process Protein Metabolic Process Proteasomal Protein Catabolic Process Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Polyubiquitination Protein K48-linked Ubiquitination Protein Catabolic Process Ubiquitin Conjugating Enzyme Activity Catabolic Process Ubiquitin-protein Transferase Activity Macromolecule Metabolic Process Cullin-RING Ubiquitin Ligase Complex Protein Monoubiquitination Cytosol Ubiquitin-like Ligase-substrate Adaptor Activity Ubiquitin Protein Ligase Binding Ubiquitin Ligase Complex Scaffold Activity Nucleus Protein K11-linked Ubiquitination Regulation Of Protein Metabolic Process Cul2-RING Ubiquitin Ligase Complex G1/S Transition Of Mitotic Cell Cycle Cellular Response To Stress Ubiquitin-like Protein Transferase Activity Cell Cycle G1/S Phase Transition Cell Cycle Phase Transition Transferase Activity SCF Ubiquitin Ligase Complex Nucleoplasm Cytoplasm Response To Stress Protein K63-linked Ubiquitination Mitotic Cell Cycle Phase Transition Ubiquitin Ligase Complex Cul4A-RING E3 Ubiquitin Ligase Complex ATP Binding Cul3-RING Ubiquitin Ligase Complex Protein Binding Regulation Of Intracellular Signal Transduction SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of TORC1 Signaling	Nucleoplasm Regulation Of Cell Cycle Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Primary Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Nucleus Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Intracellular Signal Transduction Positive Regulation Of Biosynthetic Process Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-templated Transcription RNA Polymerase II-specific DNA-binding Transcription Factor Binding Cell Population Proliferation Cellular Response To Stress Positive Regulation Of RNA Metabolic Process Regulation Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Chromatin Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Response To Hormone DNA Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Oxygen-containing Compound Negative Regulation Of Biosynthetic Process Cyclin Binding Macromolecule Metabolic Process Regulation Of Cell Cycle Process Negative Regulation Of RNA Metabolic Process Cellular Response To Hormone Stimulus G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Transcription Regulator Complex Nucleic Acid Metabolic Process Ubiquitin Protein Ligase Binding Negative Regulation Of Macromolecule Metabolic Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?