CUL4A and IRS2

		CUL4A	IRS2
Description		cullin 4A	insulin receptor substrate 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cullin-RING Ubiquitin Ligase Complex Cul4A-RING E3 Ubiquitin Ligase Complex Cul4-RING E3 Ubiquitin Ligase Complex	Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity Ubiquitin Ligase Complex Scaffold Activity	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Insulin Receptor Binding Protein Binding Protein Kinase Binding Protein Phosphatase Binding Protein Domain Specific Binding Protein-macromolecule Adaptor Activity Signaling Adaptor Activity Phosphatidylinositol 3-kinase Binding 14-3-3 Protein Binding Phosphatidylinositol 3-kinase Activator Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle In Utero Embryonic Development DNA Repair Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Spermatogenesis Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Protein Ubiquitination Hemopoiesis Negative Regulation Of Granulocyte Differentiation Developmental Process Cellular Response To UV Somatic Stem Cell Population Maintenance MiRNA-mediated Gene Silencing By MRNA Destabilization T Cell Activation Ribosome Biogenesis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Rhythmic Process Regulation Of Protein Metabolic Process Type I Interferon-mediated Signaling Pathway Intrinsic Apoptotic Signaling Pathway Base-excision Repair, AP Site Formation Via Deaminated Base Removal Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of DNA Damage Checkpoint Regulation Of Nucleotide-excision Repair	Positive Regulation Of Mesenchymal Cell Proliferation Negative Regulation Of B Cell Apoptotic Process Glucose Metabolic Process Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Brain Development Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Response To Glucose Epithelial Cell Migration Positive Regulation Of Epithelial Cell Migration Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Positive Regulation Of Glucose Metabolic Process Cell Migration Regulation Of Lipid Metabolic Process Mammary Gland Development Positive Regulation Of B Cell Proliferation Positive Regulation Of Fatty Acid Beta-oxidation Positive Regulation Of Insulin Secretion Cellular Response To Insulin Stimulus Type B Pancreatic Cell Proliferation Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of D-glucose Import Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Transport Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Lipid Homeostasis Cellular Response To Glucose Stimulus Positive Regulation Of Type B Pancreatic Cell Proliferation Cellular Response To Endothelin
Pathways		Recognition of DNA damage by PCNA-containing replication complex DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Dual Incision in GG-NER Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Neddylation	PI3K Cascade IRS-mediated signalling SOS-mediated signalling SOS-mediated signalling PIP3 activates AKT signaling Interleukin-7 signaling PI3K/AKT activation PI3K/AKT activation Constitutive Signaling by Aberrant PI3K in Cancer IRS-related events triggered by IGF1R Signaling by Leptin RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling IRS activation Signal attenuation RET signaling Signaling by Erythropoietin Signaling by Erythropoietin Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phospholipase C gamma (PLCG) Erythropoietin activates STAT5 Erythropoietin activates RAS Erythropoietin activates RAS Growth hormone receptor signaling
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Atrial fibrillation ( 30061737) Bipolar disorder ( 31043756 34002096) HDL cholesterol levels ( 32203549) Immature fraction of reticulocytes ( 32888494) Intracranial aneurysm ( 30823506) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Platelet distribution width ( 27863252 32888494) Red cell distribution width ( 32888494)	Alanine aminotransferase levels ( 34315874) Antipsychotic drug-induced weight gain in schizophrenia ( 31447353) Aspartate aminotransferase levels ( 34315874) Heel bone mineral density ( 28869591 30598549) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494) Insulin-related traits (multivariate analysis) ( 32002517) Mean corpuscular hemoglobin ( 27863252 29403010 32888494) Mean corpuscular volume ( 27863252 32888494 29403010) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Nose size ( 27182965) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Platelet count ( 29403010) Prostate cancer ( 29117387) Red cell distribution width ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494 27863252) Type 2 diabetes ( 30297969) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) White matter lesion progression ( 26451028) White matter lesion progression (adjusted for white matter lesion burden at baseline) ( 26451028)
Interacting Genes		25 interacting genes: CAND1 CDKN1B CENPA CHEK1 COMMD1 COPS2 DCUN1D4 DDB1 DDB2 H1-2 H3C1 HOXA9 LNCAROD PAFAH1B1 RBX1 SALL2 SENP8 SKP2 ST7 TP53 TUBG1 UBC UBE2D1 UBE2E3 UBE2M	40 interacting genes: AP2M1 ATP2A1 ATP2A2 BCL2L1 CRK EPOR FES GRB2 IGF1R IL4R INSR JAK1 JAK2 JAK3 MPL MTDH NEDD4 NTRK1 PIK3CA PIK3CD PIK3R1 PIK3R2 PIK3R3 PLCG1 PTPN11 PTPN6 PTPRF RPTOR SHC1 SOCS1 SOCS3 SOCS6 SOCS7 SRPK2 TYK2 UBTF YWHAB YWHAE YWHAG YWHAZ
Entrez ID		8451	8660
HPRD ID		07218	02878
Ensembl ID		ENSG00000139842	ENSG00000185950
Uniprot IDs		A0A087WWN2 A0A0A0MR50 Q13619	Q9P084 Q9Y4H2
PDB IDs		2HYE 4A0K 7OKQ 7OPC 7OPD 8B3G 8B3I	3FQW 3FQX
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Protein Modification By Small Protein Conjugation Cul4A-RING E3 Ubiquitin Ligase Complex Nucleotide-excision Repair Protein Neddylation Cul4B-RING E3 Ubiquitin Ligase Complex Protein Modification Process Nucleus Positive Regulation Of Post-translational Protein Modification Regulation Of Post-translational Protein Modification Protein Ubiquitination Nucleoplasm Cullin Family Protein Binding Cellular Response To UV Cul4-RING E3 Ubiquitin Ligase Complex Base-excision Repair, AP Site Formation Via Deaminated Base Removal Cellular Response To Light Stimulus Protein K48-linked Ubiquitination Positive Regulation Of Protein Ubiquitination Positive Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly NEDD8 Transferase Activity Regulation Of Protein Modification Process Ubiquitin-protein Transferase Activity DNA Damage Response, Signal Transduction By P53 Class Mediator Epigenetic Regulation Of Gene Expression Protein Polyubiquitination Mitotic Cell Cycle Phase Transition Signal Transduction In Response To DNA Damage Regulation Of Mitotic Cell Cycle DNA Metabolic Process Macromolecule Metabolic Process Response To UV Cellular Response To Antibiotic Cell Cycle Phase Transition DNA Repair Protein-containing Complex Protein Metabolic Process UV-damage Excision Repair Cellular Response To Radiation Protein Deneddylation DNA Damage Response Negative Regulation Of Mitophagy Chromosome Organization Positive Regulation Of Protein Metabolic Process Interferon-mediated Signaling Pathway Protein-containing Complex Binding Regulation Of Protein Ubiquitination Nuclear Membrane Disassembly Inner Cell Mass Cell Proliferation Replicative Senescence	Signal Transduction Intracellular Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Phosphotyrosine Residue Binding Protein Modification Process Insulin Receptor Substrate Binding Insulin Receptor Signaling Pathway Insulin-like Growth Factor Receptor Binding Protein Phosphorylation Phosphatidylinositol 3-kinase Complex, Class IA Regulation Of Signal Transduction Regulation Of Developmental Process Regulation Of Cell Adhesion Phosphorylation Regulation Of Immune System Process Regulation Of Cell Communication Regulation Of Signaling Cytokine-mediated Signaling Pathway Regulation Of Cellular Localization Negative Regulation Of Immune System Process Immune System Process Phosphate-containing Compound Metabolic Process Protein Metabolic Process Regulation Of Multicellular Organismal Process Cell Surface Receptor Signaling Pathway Via JAK-STAT Neurotrophin TRKA Receptor Binding Phosphoserine Residue Binding Regulation Of Cell-cell Adhesion Positive Regulation Of Immune System Process Response To Stress Cell Surface Receptor Signaling Pathway Via STAT Positive Regulation Of Cell Population Proliferation Cell Activation Protein Tyrosine Kinase Activity Regulation Of Intracellular Transport Phosphatidylinositol 3-kinase Complex Leukocyte Activation Lymphocyte Activation Regulation Of Immune Response Peptidyl-tyrosine Phosphorylation Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Growth Hormone Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Phosphatase Binding Regulation Of Leukocyte Cell-cell Adhesion Intracellular Signaling Cassette Regulation Of T Cell Activation
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