CUL4A and UBE2E3

Number of citations of the paper that reports this interaction (PMID 19256485)
6

Data Source:
BioGRID (pull down)

		CUL4A	UBE2E3
Gene Name		cullin 4A	ubiquitin-conjugating enzyme E2E 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cul4A-RING E3 Ubiquitin Ligase Complex Cul4-RING E3 Ubiquitin Ligase Complex	Nucleus Cytoplasm
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding	Ubiquitin-protein Transferase Activity ATP Binding Ligase Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle DNA Repair Cell Cycle Arrest Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Viral Process Protein Ubiquitination Hemopoiesis Negative Regulation Of Granulocyte Differentiation Somatic Stem Cell Maintenance Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Metabolic Process Intrinsic Apoptotic Signaling Pathway Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of DNA Damage Checkpoint Regulation Of Nucleotide-excision Repair	Regulation Of Growth Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination
Pathways			Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS			Celiac disease ( 20190752) Obesity ( 21552555)
Protein-Protein Interactions		21 interactors: CAND1 CDKN1B CHEK1 COMMD1 COPS2 COPS5 DCUN1D1 DCUN1D3 DCUN1D4 DCUN1D5 DDB1 DDB2 HIST1H1C HIST1H3A HOXA9 RBX1 RNF7 SALL2 SENP8 SKP2 UBE2E3	75 interactors: ACVR1 ARID3A ARIH2 ATXN1 BARD1 BRCA1 CADPS2 CHFR CHUK CNOT4 CUL1 CUL3 CUL4A DTX3 DTX3L DZIP3 HERC4 HTT IPO11 ITCH KLHL42 MARCH5 MDM2 MID1 MID2 MKRN3 MUL1 NEDD4L NFKBIA RBX1 RCBTB1 RCBTB2 RFWD3 RING1 RMND5B RNF10 RNF11 RNF111 RNF114 RNF115 RNF13 RNF130 RNF14 RNF150 RNF165 RNF166 RNF167 RNF181 RNF185 RNF2 RNF25 RNF4 RNF43 RNF5 RNF8 SAE1 SIAH1 SPOP STUB1 TGFBR1 TRIM2 TRIM27 TRIM32 TRIM37 TRIM38 TRIM39 TRIM45 TRIM50 UBA1 UBC UBOX5 UFM1 WWP2 ZNRF1 ZNRF4
Entrez ID		8451	10477
HPRD ID		07218	05000
Ensembl ID		ENSG00000139842	ENSG00000170035
Uniprot IDs		B2RBV7 Q13619	Q969T4
PDB IDs		2HYE 4A0K
Enriched GO Terms of Interacting Partners?		Protein Deneddylation Protein Ubiquitination Protein Modification By Small Protein Conjugation Response To UV Protein Monoubiquitination UV-damage Excision Repair Cellular Response To UV Cullin Deneddylation Cellular Protein Modification Process Protein Neddylation Histone H2A Monoubiquitination Cellular Response To Light Stimulus Histone H2A Ubiquitination Nucleotide-excision Repair, DNA Damage Removal Histone Monoubiquitination Protein Modification By Small Protein Removal Response To Light Stimulus Cellular Response To Radiation Response To Abiotic Stimulus Chromatin Organization Cellular Protein Metabolic Process Protein Polyubiquitination Histone Ubiquitination Response To Radiation Cellular Response To DNA Damage Stimulus Protein Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of DNA-templated Transcription In Response To Stress Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Mitotic Cell Cycle Phase Transition Proteasomal Protein Catabolic Process Cell Cycle Phase Transition Cellular Response To Stress Chromosome Organization DNA Repair Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription DNA Metabolic Process Cellular Response To Cell-matrix Adhesion Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage SCF Complex Assembly Histone H3-T11 Phosphorylation Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation By Virus Of Viral Protein Levels In Host Cell Nucleotide-excision Repair Positive Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly	Protein Modification By Small Protein Conjugation Protein Ubiquitination Cellular Protein Modification Process Protein Polyubiquitination Cellular Protein Metabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Metabolic Process Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Protein Autoubiquitination Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Cellular Metabolic Process Catabolic Process Protein K63-linked Ubiquitination Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein K48-linked Ubiquitination Protein Monoubiquitination Metabolic Process Regulation Of Signal Transduction Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Cell Cycle Regulation Of Cell Cycle Negative Regulation Of Signal Transduction Regulation Of Signaling Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Protein Catabolic Process Negative Regulation Of Signaling Histone Ubiquitination Histone H2A Ubiquitination Regulation Of Protein Catabolic Process Cell Cycle Histone Monoubiquitination Response To Stress Apoptotic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Type I Interferon Production Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Programmed Cell Death Cellular Response To Stress Protein K6-linked Ubiquitination Cell Cycle Process Regulation Of Gene Expression Positive Regulation Of Metabolic Process Mitotic Cell Cycle
Tagcloud ?		aldrich ambra1 arp2 associates autophagy becn1 ddb1 e3 elusive endosomal impairs impede interactor k48 k63 ligase linkage pik3c3 potentiates rnf2 scar sorting starvation suppresses ubiquitinate ubiquitination wash wasp wiskott	conjugating cytoprotective degraded extracting govern homeostasis imp import importin keap1 locales localizes mitochondria nrf2 outer p45 partitioning perinuclear prematurely relocalizes repressive restore restrict restricting subcellular tightly transcriptionally unresolved
Tagcloud (Difference) ?		aldrich ambra1 arp2 associates autophagy becn1 ddb1 e3 elusive endosomal impairs impede interactor k48 k63 ligase linkage pik3c3 potentiates rnf2 scar sorting starvation suppresses ubiquitinate ubiquitination wash wasp wiskott	conjugating cytoprotective degraded extracting govern homeostasis imp import importin keap1 locales localizes mitochondria nrf2 outer p45 partitioning perinuclear prematurely relocalizes repressive restore restrict restricting subcellular tightly transcriptionally unresolved
Tagcloud (Intersection) ?