CUL4A and HOXA9

Number of citations of the paper that reports this interaction (PubMedID 14609952)
33

Data Source:
BioGRID (affinity chromatography technology, pull down)

		CUL4A	HOXA9
Description		cullin 4A	homeobox A9
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cullin-RING Ubiquitin Ligase Complex Cul4A-RING E3 Ubiquitin Ligase Complex Cul4-RING E3 Ubiquitin Ligase Complex	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity Ubiquitin Ligase Complex Scaffold Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Enzyme Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle In Utero Embryonic Development DNA Repair Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Spermatogenesis Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Protein Ubiquitination Hemopoiesis Negative Regulation Of Granulocyte Differentiation Developmental Process Cellular Response To UV Somatic Stem Cell Population Maintenance MiRNA-mediated Gene Silencing By MRNA Destabilization T Cell Activation Ribosome Biogenesis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Rhythmic Process Regulation Of Protein Metabolic Process Type I Interferon-mediated Signaling Pathway Intrinsic Apoptotic Signaling Pathway Base-excision Repair, AP Site Formation Via Deaminated Base Removal Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of DNA Damage Checkpoint Regulation Of Nucleotide-excision Repair	DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Spermatogenesis Single Fertilization Male Gonad Development Anterior/posterior Pattern Specification Proximal/distal Pattern Formation Regulation Of Gene Expression Prostate Gland Development Mammary Gland Development Response To Testosterone Embryonic Forelimb Morphogenesis Endothelial Cell Activation Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Embryonic Skeletal System Morphogenesis Embryonic Skeletal System Development Uterus Development Definitive Hemopoiesis
Pathways		Recognition of DNA damage by PCNA-containing replication complex DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Dual Incision in GG-NER Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Neddylation
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Atrial fibrillation ( 30061737) Bipolar disorder ( 31043756 34002096) HDL cholesterol levels ( 32203549) Immature fraction of reticulocytes ( 32888494) Intracranial aneurysm ( 30823506) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Platelet distribution width ( 27863252 32888494) Red cell distribution width ( 32888494)	A body shape index ( 34021172) Hypertension ( 30487518) Mean arterial pressure ( 30487518) Mean corpuscular volume ( 32888494) Monocyte percentage of white cells ( 32888494) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Platelet count ( 32888494) Plateletcrit ( 32888494) Red blood cell count ( 32888494) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		25 interacting genes: CAND1 CDKN1B CENPA CHEK1 COMMD1 COPS2 DCUN1D4 DDB1 DDB2 H1-2 H3C1 HOXA9 LNCAROD PAFAH1B1 RBX1 SALL2 SENP8 SKP2 ST7 TP53 TUBG1 UBC UBE2D1 UBE2E3 UBE2M	18 interacting genes: CREBBP CUL4A EIF4E JUN KRTAP10-1 KRTAP9-3 MEIS1 MEIS2 NFKBIA PBX1 PBX2 PBX3 PLSCR1 RBPMS SMAD2 SMAD4 TMEM132D TRIP6
Entrez ID		8451	3205
HPRD ID		07218	00844
Ensembl ID		ENSG00000139842	ENSG00000078399
Uniprot IDs		A0A087WWN2 A0A0A0MR50 Q13619	P31269
PDB IDs		2HYE 4A0K 7OKQ 7OPC 7OPD 8B3G 8B3I
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Protein Modification By Small Protein Conjugation Cul4A-RING E3 Ubiquitin Ligase Complex Nucleotide-excision Repair Protein Neddylation Cul4B-RING E3 Ubiquitin Ligase Complex Protein Modification Process Nucleus Positive Regulation Of Post-translational Protein Modification Regulation Of Post-translational Protein Modification Protein Ubiquitination Nucleoplasm Cullin Family Protein Binding Cellular Response To UV Cul4-RING E3 Ubiquitin Ligase Complex Base-excision Repair, AP Site Formation Via Deaminated Base Removal Cellular Response To Light Stimulus Protein K48-linked Ubiquitination Positive Regulation Of Protein Ubiquitination Positive Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly NEDD8 Transferase Activity Regulation Of Protein Modification Process Ubiquitin-protein Transferase Activity DNA Damage Response, Signal Transduction By P53 Class Mediator Epigenetic Regulation Of Gene Expression Protein Polyubiquitination Mitotic Cell Cycle Phase Transition Signal Transduction In Response To DNA Damage Regulation Of Mitotic Cell Cycle DNA Metabolic Process Macromolecule Metabolic Process Response To UV Cellular Response To Antibiotic Cell Cycle Phase Transition DNA Repair Protein-containing Complex Protein Metabolic Process UV-damage Excision Repair Cellular Response To Radiation Protein Deneddylation DNA Damage Response Negative Regulation Of Mitophagy Chromosome Organization Positive Regulation Of Protein Metabolic Process Interferon-mediated Signaling Pathway Protein-containing Complex Binding Regulation Of Protein Ubiquitination Nuclear Membrane Disassembly Inner Cell Mass Cell Proliferation Replicative Senescence	Transcription Regulator Complex DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II SMAD Protein Signal Transduction Pattern Specification Process Eye Development Negative Regulation Of Cell Differentiation Chromatin Embryonic Pattern Specification Animal Organ Morphogenesis Positive Regulation Of Macromolecule Metabolic Process Sensory Organ Development Positive Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Binding Positive Regulation Of Biosynthetic Process Negative Regulation Of Developmental Process Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Myeloid Cell Differentiation R-SMAD Binding Activin Responsive Factor Complex Brain Development Anatomical Structure Morphogenesis Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Binding Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regionalization Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Mitotic Cell Cycle Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cell Cycle Regulation Of Primary Metabolic Process SMAD Protein Complex Anterior/posterior Pattern Specification Heteromeric SMAD Protein Complex RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Activity Animal Organ Development Negative Regulation Of Neuron Differentiation Embryonic Morphogenesis Regulation Of Myeloid Cell Differentiation Nucleus
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