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CUL4A and COPS2
Number of citations of the paper that reports this interaction (PMID
25349427
)
0
Data Source:
BioGRID
(pull down, affinity chromatography technology)
CUL4A
COPS2
Gene Name
cullin 4A
COP9 signalosome subunit 2
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Cul4A-RING E3 Ubiquitin Ligase Complex
Cul4-RING E3 Ubiquitin Ligase Complex
Cytoplasm
COP9 Signalosome
Molecular Function
Protein Binding
Ubiquitin Protein Ligase Binding
Transcription Corepressor Activity
Signal Transducer Activity
Protein Binding
Biological Process
G1/S Transition Of Mitotic Cell Cycle
DNA Repair
Cell Cycle Arrest
Positive Regulation Of Cell Proliferation
Negative Regulation Of Cell Proliferation
Viral Process
Protein Ubiquitination
Hemopoiesis
Negative Regulation Of Granulocyte Differentiation
Somatic Stem Cell Maintenance
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Regulation Of Protein Metabolic Process
Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Regulation Of DNA Damage Checkpoint
Regulation Of Nucleotide-excision Repair
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Transcription From RNA Polymerase II Promoter
Signal Transduction
Cell Proliferation
Cullin Deneddylation
Neuron Differentiation
Skeletal Muscle Cell Differentiation
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions
21 interactors:
CAND1
CDKN1B
CHEK1
COMMD1
COPS2
COPS5
DCUN1D1
DCUN1D3
DCUN1D4
DCUN1D5
DDB1
DDB2
HIST1H1C
HIST1H3A
HOXA9
RBX1
RNF7
SALL2
SENP8
SKP2
UBE2E3
39 interactors:
COPS3
COPS4
COPS5
COPS6
COPS7A
COPS8
CSNK2A1
CSNK2B
CUL1
CUL4A
CUL5
DDB1
EP300
GFER
GPS1
HIST1H3A
HIST1H4A
ING1
ING2
IP6K1
IRF8
JUN
MAP3K10
MAPK8
NCOR1
NIF3L1
NR0B1
NR2F1
PRKD1
PSMD4
RARA
RXRA
SENP8
SIN3A
SIN3B
THRA
THRB
TP53
VDR
Entrez ID
8451
9318
HPRD ID
07218
05146
Ensembl ID
ENSG00000139842
ENSG00000166200
Uniprot IDs
B2RBV7
Q13619
P61201
Q59EL2
PDB IDs
2HYE
4A0K
Enriched GO Terms of Interacting Partners
?
Protein Deneddylation
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Response To UV
Protein Monoubiquitination
UV-damage Excision Repair
Cellular Response To UV
Cullin Deneddylation
Cellular Protein Modification Process
Protein Neddylation
Histone H2A Monoubiquitination
Cellular Response To Light Stimulus
Histone H2A Ubiquitination
Nucleotide-excision Repair, DNA Damage Removal
Histone Monoubiquitination
Protein Modification By Small Protein Removal
Response To Light Stimulus
Cellular Response To Radiation
Response To Abiotic Stimulus
Chromatin Organization
Cellular Protein Metabolic Process
Protein Polyubiquitination
Histone Ubiquitination
Response To Radiation
Cellular Response To DNA Damage Stimulus
Protein Metabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of DNA-templated Transcription In Response To Stress
Regulation Of Cell Cycle Phase Transition
Regulation Of Cell Cycle
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Mitotic Cell Cycle Phase Transition
Proteasomal Protein Catabolic Process
Cell Cycle Phase Transition
Cellular Response To Stress
Chromosome Organization
DNA Repair
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
DNA Metabolic Process
Cellular Response To Cell-matrix Adhesion
Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage
SCF Complex Assembly
Histone H3-T11 Phosphorylation
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Positive Regulation By Virus Of Viral Protein Levels In Host Cell
Nucleotide-excision Repair
Positive Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly
Protein Deneddylation
Cullin Deneddylation
Negative Regulation Of Transcription, DNA-templated
Cellular Metabolic Process
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Positive Regulation Of Cellular Metabolic Process
Negative Regulation Of Gene Expression
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Cellular Metabolic Process
Positive Regulation Of Metabolic Process
Protein Modification By Small Protein Removal
Transcription From RNA Polymerase II Promoter
Cellular Protein Modification Process
Hormone-mediated Signaling Pathway
Positive Regulation Of Gene Expression
Positive Regulation Of Transcription, DNA-templated
Transcription Initiation From RNA Polymerase II Promoter
Steroid Hormone Mediated Signaling Pathway
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Nitrogen Compound Metabolic Process
Positive Regulation Of Cellular Biosynthetic Process
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Cellular Protein Metabolic Process
Signal Transduction
DNA-templated Transcription, Initiation
Regulation Of RNA Metabolic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Metabolic Process
Negative Regulation Of Cell Proliferation
Regulation Of Transcription From RNA Polymerase II Promoter
Cellular Response To Organic Substance
Signaling
Cellular Response To Steroid Hormone Stimulus
Regulation Of Protein Metabolic Process
Regulation Of Cell Cycle
Regulation Of Protein Deacetylation
Cellular Response To Lipid
Metabolic Process
Cell Communication
Intracellular Receptor Signaling Pathway
Regulation Of Cellular Protein Metabolic Process
Regulation Of Gene Expression
Transcription, DNA-templated
RNA Biosynthetic Process
Regulation Of Cell Death
Gene Expression
Tagcloud
?
aldrich
ambra1
arp2
associates
autophagy
becn1
ddb1
e3
elusive
endosomal
impairs
impede
interactor
k48
k63
ligase
linkage
pik3c3
potentiates
rnf2
scar
sorting
starvation
suppresses
ubiquitinate
ubiquitination
wash
wasp
wiskott
Tagcloud (Difference)
?
aldrich
ambra1
arp2
associates
autophagy
becn1
ddb1
e3
elusive
endosomal
impairs
impede
interactor
k48
k63
ligase
linkage
pik3c3
potentiates
rnf2
scar
sorting
starvation
suppresses
ubiquitinate
ubiquitination
wash
wasp
wiskott
Tagcloud (Intersection)
?