CUL4A and PAFAH1B1

Number of citations of the paper that reports this interaction (PubMedID 32235678)
115

Data Source:
BioGRID (affinity chromatography technology, pull down)

		CUL4A	PAFAH1B1
Description		cullin 4A	platelet activating factor acetylhydrolase 1b regulatory subunit 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cullin-RING Ubiquitin Ligase Complex Cul4A-RING E3 Ubiquitin Ligase Complex Cul4-RING E3 Ubiquitin Ligase Complex	Astral Microtubule Kinetochore Nucleus Nuclear Envelope Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Kinesin Complex Microtubule Microtubule Associated Complex Cytoplasmic Microtubule Cell Cortex 1-alkyl-2-acetylglycerophosphocholine Esterase Complex Microtubule Cytoskeleton Membrane Axon Growth Cone Cell Leading Edge Motile Cilium Nuclear Membrane Vesicle Stereocilium Neuron Projection Neuronal Cell Body Perinuclear Region Of Cytoplasm Extracellular Exosome Central Region Of Growth Cone Schaffer Collateral - CA1 Synapse Glutamatergic Synapse Axon Cytoplasm
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity Ubiquitin Ligase Complex Scaffold Activity	Protein Binding Microtubule Binding Heparin Binding Dynactin Binding Identical Protein Binding Phospholipase Binding Protein-containing Complex Binding Dynein Intermediate Chain Binding Protein Heterodimerization Activity Microtubule Plus-end Binding Phosphoprotein Binding Dynein Complex Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle In Utero Embryonic Development DNA Repair Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Spermatogenesis Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Protein Ubiquitination Hemopoiesis Negative Regulation Of Granulocyte Differentiation Developmental Process Cellular Response To UV Somatic Stem Cell Population Maintenance MiRNA-mediated Gene Silencing By MRNA Destabilization T Cell Activation Ribosome Biogenesis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Rhythmic Process Regulation Of Protein Metabolic Process Type I Interferon-mediated Signaling Pathway Intrinsic Apoptotic Signaling Pathway Base-excision Repair, AP Site Formation Via Deaminated Base Removal Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of DNA Damage Checkpoint Regulation Of Nucleotide-excision Repair	Establishment Of Mitotic Spindle Orientation Microtubule Cytoskeleton Organization Ameboidal-type Cell Migration Acrosome Assembly Neuron Migration Positive Regulation Of Cytokine-mediated Signaling Pathway Lipid Metabolic Process Microtubule-based Process Nuclear Migration JNK Cascade Chemical Synaptic Transmission Germ Cell Development Nervous System Development Neuroblast Proliferation Learning Or Memory Retrograde Axonal Transport Adult Locomotory Behavior Protein Secretion Negative Regulation Of Neuron Projection Development Lipid Catabolic Process Cell Migration Stem Cell Division Transmission Of Nerve Impulse Corpus Callosum Morphogenesis Hippocampus Development Layer Formation In Cerebral Cortex Cerebral Cortex Neuron Differentiation Cerebral Cortex Development Actin Cytoskeleton Organization Cell Differentiation Forebrain Development Microtubule Organizing Center Organization Osteoclast Development Reelin-mediated Signaling Pathway Positive Regulation Of Embryonic Development Establishment Of Planar Polarity Of Embryonic Epithelium Cortical Microtubule Organization Positive Regulation Of Axon Extension Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of JNK Cascade Platelet Activating Factor Metabolic Process Vesicle Transport Along Microtubule Brain Morphogenesis Modulation Of Chemical Synaptic Transmission Neuromuscular Process Controlling Balance Microtubule Sliding Nuclear Membrane Disassembly Positive Regulation Of Cellular Component Organization Cell Division Establishment Of Localization In Cell Establishment Of Organelle Localization Establishment Of Centrosome Localization Maintenance Of Centrosome Location Auditory Receptor Cell Development Positive Regulation Of Dendritic Spine Morphogenesis Regulation Of Microtubule Cytoskeleton Organization Cochlea Development Microtubule Cytoskeleton Organization Involved In Establishment Of Planar Polarity Myeloid Leukocyte Migration Regulation Of Postsynapse Organization Radial Glia-guided Pyramidal Neuron Migration Interneuron Migration
Pathways		Recognition of DNA damage by PCNA-containing replication complex DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Dual Incision in GG-NER Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Neddylation	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase AURKA Activation by TPX2 EML4 and NUDC in mitotic spindle formation
Drugs
Diseases			Lissencephaly (LIS); Miller-Dieker syndrome (MDLS)
GWAS		Apolipoprotein A1 levels ( 32203549) Atrial fibrillation ( 30061737) Bipolar disorder ( 31043756 34002096) HDL cholesterol levels ( 32203549) Immature fraction of reticulocytes ( 32888494) Intracranial aneurysm ( 30823506) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Platelet distribution width ( 27863252 32888494) Red cell distribution width ( 32888494)	Adverse response to drug ( 30420678) Anxiety ( 33859377) Depression ( 33859377) Mean platelet volume ( 32888494) Neurociticism ( 29500382) Neuroticism ( 27089181) Self-reported tiredness ( 28194004)
Interacting Genes		25 interacting genes: CAND1 CDKN1B CENPA CHEK1 COMMD1 COPS2 DCUN1D4 DDB1 DDB2 H1-2 H3C1 HOXA9 LNCAROD PAFAH1B1 RBX1 SALL2 SENP8 SKP2 ST7 TP53 TUBG1 UBC UBE2D1 UBE2E3 UBE2M	26 interacting genes: CLIP1 CRYAA CSNK2A1 CUL4A CUL4B DAB1 DCTN1 DCTN2 DCX DNAI1 FBXO7 HSPH1 KARS1 KATNA1 KATNB1 MAP1B MAP2 NDE1 NDEL1 NUDC PAFAH1B2 PAFAH1B3 PDE4D SLC25A21-AS1 TNIK TUBA1A
Entrez ID		8451	5048
HPRD ID		07218	03329
Ensembl ID		ENSG00000139842	ENSG00000007168
Uniprot IDs		A0A087WWN2 A0A0A0MR50 Q13619	A0A6Q8PFT2 A0A6Q8PFU3 P43034
PDB IDs		2HYE 4A0K 7OKQ 7OPC 7OPD 8B3G 8B3I	7MT1 8DYU 8DYV 8FDT 8FDU 8PQW 8PQY 8PQZ 8PTK
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Protein Modification By Small Protein Conjugation Cul4A-RING E3 Ubiquitin Ligase Complex Nucleotide-excision Repair Protein Neddylation Cul4B-RING E3 Ubiquitin Ligase Complex Protein Modification Process Nucleus Positive Regulation Of Post-translational Protein Modification Regulation Of Post-translational Protein Modification Protein Ubiquitination Nucleoplasm Cullin Family Protein Binding Cellular Response To UV Cul4-RING E3 Ubiquitin Ligase Complex Base-excision Repair, AP Site Formation Via Deaminated Base Removal Cellular Response To Light Stimulus Protein K48-linked Ubiquitination Positive Regulation Of Protein Ubiquitination Positive Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly NEDD8 Transferase Activity Regulation Of Protein Modification Process Ubiquitin-protein Transferase Activity DNA Damage Response, Signal Transduction By P53 Class Mediator Epigenetic Regulation Of Gene Expression Protein Polyubiquitination Mitotic Cell Cycle Phase Transition Signal Transduction In Response To DNA Damage Regulation Of Mitotic Cell Cycle DNA Metabolic Process Macromolecule Metabolic Process Response To UV Cellular Response To Antibiotic Cell Cycle Phase Transition DNA Repair Protein-containing Complex Protein Metabolic Process UV-damage Excision Repair Cellular Response To Radiation Protein Deneddylation DNA Damage Response Negative Regulation Of Mitophagy Chromosome Organization Positive Regulation Of Protein Metabolic Process Interferon-mediated Signaling Pathway Protein-containing Complex Binding Regulation Of Protein Ubiquitination Nuclear Membrane Disassembly Inner Cell Mass Cell Proliferation Replicative Senescence	Microtubule Microtubule Cytoskeleton Organization Microtubule-based Process Microtubule Binding Cytoskeleton Cytoskeleton Organization Microtubule Associated Complex Organelle Localization Cytosol Cytoplasm Neuron Migration Establishment Of Organelle Localization Chromosome Localization Centrosome Regulation Of Microtubule Polymerization Or Depolymerization Organelle Organization Microtubule-based Transport Spindle Nervous System Development Microtubule-based Movement Microtubule Cytoskeleton Organization Involved In Mitosis Microtubule Cytoskeleton Neuron Projection Morphogenesis Regulation Of Neuron Projection Development Regulation Of Microtubule Polymerization Cell Projection Morphogenesis Regulation Of Microtubule Cytoskeleton Organization Kinetochore Transport Along Microtubule Platelet-activating Factor Acetyltransferase Activity 1-alkyl-2-acetylglycerophosphocholine Esterase Complex Organelle Transport Along Microtubule Cytoskeleton-dependent Intracellular Transport Protein Heterodimerization Activity Positive Regulation Of Microtubule Polymerization Establishment Of Vesicle Localization Dynein Complex Establishment Of Mitotic Spindle Orientation Basal Dendrite Katanin Complex Radial Glia-guided Pyramidal Neuron Migration Establishment Of Mitotic Spindle Localization Vesicle Localization Mitotic Centrosome Separation Regulation Of Plasma Membrane Bounded Cell Projection Organization Dendrite Development Establishment Of Spindle Orientation Negative Regulation Of Microtubule Polymerization Or Depolymerization Regulation Of Microtubule-based Process Axon Hillock
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