CUL4A and CAND1

Number of citations of the paper that reports this interaction (PMID 12504025)
93

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo)

		CUL4A	CAND1
Gene Name		cullin 4A	cullin-associated and neddylation-dissociated 1
Image
Gene Ontology Annotations	Cellular Component	Cul4A-RING E3 Ubiquitin Ligase Complex Cul4-RING E3 Ubiquitin Ligase Complex	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Membrane Cullin-RING Ubiquitin Ligase Complex Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding	Protein Binding TBP-class Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle DNA Repair Cell Cycle Arrest Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Viral Process Protein Ubiquitination Hemopoiesis Negative Regulation Of Granulocyte Differentiation Somatic Stem Cell Maintenance Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Metabolic Process Intrinsic Apoptotic Signaling Pathway Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of DNA Damage Checkpoint Regulation Of Nucleotide-excision Repair	SCF Complex Assembly Protein Ubiquitination Cell Differentiation Negative Regulation Of Catalytic Activity Positive Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly
Pathways
Drugs
Diseases
GWAS			Hippocampal atrophy ( 19668339)
Protein-Protein Interactions		21 interactors: CAND1 CDKN1B CHEK1 COMMD1 COPS2 COPS5 DCUN1D1 DCUN1D3 DCUN1D4 DCUN1D5 DDB1 DDB2 HIST1H1C HIST1H3A HOXA9 RBX1 RNF7 SALL2 SENP8 SKP2 UBE2E3	10 interactors: CNOT3 CUL1 CUL2 CUL3 CUL4A CUL4B DCUN1D1 RBX1 SRPK2 UBE2M
Entrez ID		8451	55832
HPRD ID		07218	06983
Ensembl ID		ENSG00000139842
Uniprot IDs		B2RBV7 Q13619	Q86VP6
PDB IDs		2HYE 4A0K	1U6G 4A0C
Enriched GO Terms of Interacting Partners?		Protein Deneddylation Protein Ubiquitination Protein Modification By Small Protein Conjugation Response To UV Protein Monoubiquitination UV-damage Excision Repair Cellular Response To UV Cullin Deneddylation Cellular Protein Modification Process Protein Neddylation Histone H2A Monoubiquitination Cellular Response To Light Stimulus Histone H2A Ubiquitination Nucleotide-excision Repair, DNA Damage Removal Histone Monoubiquitination Protein Modification By Small Protein Removal Response To Light Stimulus Cellular Response To Radiation Response To Abiotic Stimulus Chromatin Organization Cellular Protein Metabolic Process Protein Polyubiquitination Histone Ubiquitination Response To Radiation Cellular Response To DNA Damage Stimulus Protein Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of DNA-templated Transcription In Response To Stress Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Mitotic Cell Cycle Phase Transition Proteasomal Protein Catabolic Process Cell Cycle Phase Transition Cellular Response To Stress Chromosome Organization DNA Repair Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription DNA Metabolic Process Cellular Response To Cell-matrix Adhesion Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage SCF Complex Assembly Histone H3-T11 Phosphorylation Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation By Virus Of Viral Protein Levels In Host Cell Nucleotide-excision Repair Positive Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly	Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Monoubiquitination Cellular Macromolecule Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Cell Cycle Arrest G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle Intrinsic Apoptotic Signaling Pathway Catabolic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Cellular Protein Modification Process Protein Neddylation Apoptotic Signaling Pathway Proteolysis Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Cellular Protein Metabolic Process Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Cell Cycle G1/S Phase Transition Trophectodermal Cell Differentiation Viral Process Positive Regulation Of Protein Catabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Cell Cycle Mitotic Cell Cycle Process Blastocyst Formation Mitotic Cell Cycle Regulation Of Cell Proliferation Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Protein Metabolic Process Regulation Of DNA-templated Transcription In Response To Stress Positive Regulation Of Neuron Apoptotic Process Nuclear Speck Organization Regulation Of Nucleotide-excision Repair Positive Regulation Of Neuron Death
Tagcloud ?		aldrich ambra1 arp2 associates autophagy becn1 ddb1 e3 elusive endosomal impairs impede interactor k48 k63 ligase linkage pik3c3 potentiates rnf2 scar sorting starvation suppresses ubiquitinate ubiquitination wash wasp wiskott	cdk2 character diagnomx diagnosticpathology differentially dysregulated enrichment eu failure hope http hub omnibus ontology pls powerful preventive rela representation shed signatures slide slides smurf1 squares srsf1 virtual www ywhae
Tagcloud (Difference) ?		aldrich ambra1 arp2 associates autophagy becn1 ddb1 e3 elusive endosomal impairs impede interactor k48 k63 ligase linkage pik3c3 potentiates rnf2 scar sorting starvation suppresses ubiquitinate ubiquitination wash wasp wiskott	cdk2 character diagnomx diagnosticpathology differentially dysregulated enrichment eu failure hope http hub omnibus ontology pls powerful preventive rela representation shed signatures slide slides smurf1 squares srsf1 virtual www ywhae
Tagcloud (Intersection) ?