CUL4A and SKP2

Number of citations of the paper that reports this interaction (PMID 16537899)
33

Data Source:
HPRD (in vitro)

		CUL4A	SKP2
Gene Name		cullin 4A	S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
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Gene Ontology Annotations	Cellular Component	Cul4A-RING E3 Ubiquitin Ligase Complex Cul4-RING E3 Ubiquitin Ligase Complex	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Aggresome SCF Ubiquitin Ligase Complex
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding	Ubiquitin-protein Transferase Activity Protein Binding Identical Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle DNA Repair Cell Cycle Arrest Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Viral Process Protein Ubiquitination Hemopoiesis Negative Regulation Of Granulocyte Differentiation Somatic Stem Cell Maintenance Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Metabolic Process Intrinsic Apoptotic Signaling Pathway Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of DNA Damage Checkpoint Regulation Of Nucleotide-excision Repair	G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Protein Polyubiquitination Mitotic Cell Cycle Cell Proliferation Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of Smooth Muscle Cell Proliferation Regulation Of Cell Cycle Cellular Response To Cell-matrix Adhesion
Pathways			APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Antigen processing: Ubiquitination & Proteasome degradation G1 Phase S Phase Cyclin E associated events during G1/S transition APC/C-mediated degradation of cell cycle proteins Cell Cycle, Mitotic SCF(Skp2)-mediated degradation of p27/p21 Cyclin D associated events in G1 G1/S Transition Regulation of mitotic cell cycle Class I MHC mediated antigen processing & presentation Cyclin A:Cdk2-associated events at S phase entry SCF(Skp2)-mediated degradation of p27/p21 Mitotic G1-G1/S phases Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		21 interactors: CAND1 CDKN1B CHEK1 COMMD1 COPS2 COPS5 DCUN1D1 DCUN1D3 DCUN1D4 DCUN1D5 DDB1 DDB2 HIST1H1C HIST1H3A HOXA9 RBX1 RNF7 SALL2 SENP8 SKP2 UBE2E3	54 interactors: AKT1 BTG1 BTG2 CCNA2 CCNE1 CCNT1 CDC14B CDC34 CDH1 CDK2 CDK9 CDKN1A CDKN1B CDKN1C CDT1 CEBPA CHKA CKS1B CKS1BP7 CUL1 CUL4A DDB1 DUSP1 E2F1 ELF4 ESR1 FZR1 GPS1 KPNA1 KPNA6 MYB MYBL2 MYC NLK ORC1 PFDN1 PIM1 PSMD9 RAG2 RB1 RBL2 RND3 SIRT4 SIRT6 SKP1 SMAD4 TAL1 TCF3 TRIM21 UBB VHL WEE1 YWHAB YY1
Entrez ID		8451	6502
HPRD ID		07218	03256
Ensembl ID		ENSG00000139842	ENSG00000145604
Uniprot IDs		B2RBV7 Q13619	Q13309
PDB IDs		2HYE 4A0K	1FQV 1FS1 1FS2 1LDK 2ASS 2AST
Enriched GO Terms of Interacting Partners?		Protein Deneddylation Protein Ubiquitination Protein Modification By Small Protein Conjugation Response To UV Protein Monoubiquitination UV-damage Excision Repair Cellular Response To UV Cullin Deneddylation Cellular Protein Modification Process Protein Neddylation Histone H2A Monoubiquitination Cellular Response To Light Stimulus Histone H2A Ubiquitination Nucleotide-excision Repair, DNA Damage Removal Histone Monoubiquitination Protein Modification By Small Protein Removal Response To Light Stimulus Cellular Response To Radiation Response To Abiotic Stimulus Chromatin Organization Cellular Protein Metabolic Process Protein Polyubiquitination Histone Ubiquitination Response To Radiation Cellular Response To DNA Damage Stimulus Protein Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of DNA-templated Transcription In Response To Stress Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Mitotic Cell Cycle Phase Transition Proteasomal Protein Catabolic Process Cell Cycle Phase Transition Cellular Response To Stress Chromosome Organization DNA Repair Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription DNA Metabolic Process Cellular Response To Cell-matrix Adhesion Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage SCF Complex Assembly Histone H3-T11 Phosphorylation Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation By Virus Of Viral Protein Levels In Host Cell Nucleotide-excision Repair Positive Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Cell Cycle Cell Cycle Cell Cycle Process Mitotic Cell Cycle Mitotic Cell Cycle Process Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Metabolic Process Positive Regulation Of Gene Expression Regulation Of Cell Cycle Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Cellular Process Regulation Of Mitotic Cell Cycle Cell Cycle Checkpoint Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Cellular Metabolic Process Positive Regulation Of Cell Cycle Regulation Of Cell Proliferation DNA Damage Checkpoint Cellular Response To DNA Damage Stimulus Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Cell Cycle Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Gene Expression Regulation Of Ubiquitin-protein Transferase Activity Cellular Response To Stress Negative Regulation Of Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Catalytic Activity Negative Regulation Of Transferase Activity DNA Metabolic Process Cellular Protein Modification Process
Tagcloud ?		aldrich ambra1 arp2 associates autophagy becn1 ddb1 e3 elusive endosomal impairs impede interactor k48 k63 ligase linkage pik3c3 potentiates rnf2 scar sorting starvation suppresses ubiquitinate ubiquitination wash wasp wiskott	antisense box cdc53 cdk2 cip1 complex cul cullin deregulation e3 g1 hallmark kip1 ligase lived member oligodeoxynucleotides oligonucleotides p19 p21 p27 p45 proteolysis raises scf skp1 transformed ubiquitin waf1
Tagcloud (Difference) ?		aldrich ambra1 arp2 associates autophagy becn1 ddb1 elusive endosomal impairs impede interactor k48 k63 linkage pik3c3 potentiates rnf2 scar sorting starvation suppresses ubiquitinate ubiquitination wash wasp wiskott	antisense box cdc53 cdk2 cip1 complex cul cullin deregulation g1 hallmark kip1 lived member oligodeoxynucleotides oligonucleotides p19 p21 p27 p45 proteolysis raises scf skp1 transformed ubiquitin waf1
Tagcloud (Intersection) ?		e3 ligase