TF and TIMELESS

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		TF	TIMELESS
Gene Name		transferrin	timeless circadian clock
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Early Endosome Late Endosome Coated Pit Basal Plasma Membrane Cell Surface Endosome Membrane Cytoplasmic Membrane-bounded Vesicle Apical Plasma Membrane Endocytic Vesicle Vesicle Secretory Granule Lumen Basal Part Of Cell Perinuclear Region Of Cytoplasm Recycling Endosome Extracellular Vesicular Exosome Blood Microparticle	Nuclear Chromatin Nucleus Nucleolus Microtubule Cytoskeleton
	Molecular Function	Protein Binding Ferric Iron Binding Ubiquitin Protein Ligase Binding	Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity
	Biological Process	Retina Homeostasis Platelet Degranulation Cellular Iron Ion Homeostasis Blood Coagulation Platelet Activation Transferrin Transport Transmembrane Transport	Negative Regulation Of Transcription From RNA Polymerase II Promoter Morphogenesis Of An Epithelium Transcription, DNA-templated Cellular Response To DNA Damage Stimulus Mitotic Nuclear Division Circadian Rhythm Detection Of Abiotic Stimulus Response To Abiotic Stimulus Lung Development Regulation Of Cell Proliferation Regulation Of Circadian Rhythm Cell Cycle Phase Transition Negative Regulation Of Transcription, DNA-templated Branching Morphogenesis Of An Epithelial Tube Cell Division
Pathways		Response to elevated platelet cytosolic Ca2+ Iron uptake and transport Platelet degranulation Transferrin endocytosis and recycling Platelet activation, signaling and aggregation
Drugs		Aluminium
Diseases
GWAS		Alcohol consumption (transferrin glycosylation) ( 21665994) Hepcidin levels ( 21785125) Iron levels ( 21208937) Iron status biomarkers ( 21483845 19084217)	Immune reponse to smallpox (secreted IFN-alpha) ( 22610502)
Protein-Protein Interactions		20 interactors: CALR CANX CUBN GRB2 IGF1 IGF2 IGFBP1 IGFBP2 IGFBP3 IGFBP4 IGFBP5 IGFBP6 LAMC3 SH3BP2 SMAD3 TFR2 TFRC TIMELESS TUBB3 VKORC1	9 interactors: CHEK1 CRY1 CRY2 PCBD1 PER1 PER2 TF TIPIN ZSCAN1
Entrez ID		7018	8914
HPRD ID		01811	04864
Ensembl ID		ENSG00000091513	ENSG00000111602
Uniprot IDs		A0PJA6 J3KN47 P02787 Q06AH7	Q9UNS1
PDB IDs		1A8E 1A8F 1B3E 1BP5 1BTJ 1D3K 1D4N 1DTG 1FQE 1FQF 1JQF 1N7W 1N7X 1N84 1OQG 1OQH 1RYO 1SUV 2HAU 2HAV 2O7U 2O84 3FGS 3QYT 3S9L 3S9M 3S9N 3SKP 3V83 3V89 3V8X 3VE1 4H0W
Enriched GO Terms of Interacting Partners?		Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Cell Growth Regulation Of Growth Regulation Of Glucose Metabolic Process Regulation Of Cellular Component Organization Developmental Process Regulation Of Carbohydrate Metabolic Process Type B Pancreatic Cell Proliferation Receptor-mediated Endocytosis Regulation Of Signal Transduction Positive Regulation Of Cell Adhesion Positive Regulation Of Activated T Cell Proliferation Regulation Of Signaling Ossification Regulation Of Activated T Cell Proliferation Positive Regulation Of Signal Transduction Osteoblast Differentiation Regulation Of Phosphorylation Regulation Of Smooth Muscle Cell Migration Wound Healing Regulation Of Cell Adhesion Endocytosis Vesicle-mediated Transport Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Cell Proliferation Response To Wounding Anatomical Structure Development System Development Positive Regulation Of T Cell Activation Exocrine Pancreas Development Positive Regulation Of Homotypic Cell-cell Adhesion Striated Muscle Cell Differentiation Positive Regulation Of Protein Kinase B Signaling Cellular Protein Metabolic Process Tissue Development Positive Regulation Of Cell-cell Adhesion Positive Regulation Of T Cell Proliferation Morphogenesis Of An Epithelium Organ Development Positive Regulation Of Phosphorylation Positive Regulation Of Glycogen Biosynthetic Process Developmental Growth Skeletal System Development Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Smooth Muscle Cell Migration Multicellular Organismal Development Regulation Of T Cell Activation Positive Regulation Of Cell Activation	Negative Regulation Of Glucocorticoid Receptor Signaling Pathway Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Negative Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Response To Light Stimulus Photoperiodism Entrainment Of Circadian Clock Blue Light Signaling Pathway Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Response To Radiation Circadian Rhythm Response To Blue Light Circadian Regulation Of Translation Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Cellular Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Macromolecule Biosynthetic Process DNA Damage Induced Protein Phosphorylation Rhythmic Process Cellular Response To Light Stimulus Protein-chromophore Linkage Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Cellular Response To Radiation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Abiotic Stimulus Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Transcription, DNA-templated Nitrogen Compound Metabolic Process Histone H3 Deacetylation RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Gluconeogenesis Regulation Of RNA Metabolic Process Regulation Of Cell Cycle Histone Deacetylation Hexose Biosynthetic Process Protein Deacetylation Histone Modification RNA Metabolic Process Regulation Of Gene Expression Negative Regulation Of DNA-templated Transcription, Termination
Tagcloud ?		alleviated bhlh c2 c3h10t1 cip coactivator cofactor cognate cor corepressors coup crosstalk forced helix hinge interacted invitro myod myogenic orphan pluripotential repress repression rip13 silences smrt thatcoup transcriptionally waf	ancestral anthropogenic arthropod calanus californicus circadian clock clockwork copepod copepods crustacean cryptochrome daphnia doubletime finmarchicus inputs intertidal orange pacemaker publicly pulex rhythms shaggy stressor stressors suite supernumerary tigriopus vrille
Tagcloud (Difference) ?		alleviated bhlh c2 c3h10t1 cip coactivator cofactor cognate cor corepressors coup crosstalk forced helix hinge interacted invitro myod myogenic orphan pluripotential repress repression rip13 silences smrt thatcoup transcriptionally waf	ancestral anthropogenic arthropod calanus californicus circadian clock clockwork copepod copepods crustacean cryptochrome daphnia doubletime finmarchicus inputs intertidal orange pacemaker publicly pulex rhythms shaggy stressor stressors suite supernumerary tigriopus vrille
Tagcloud (Intersection) ?