TF and GPX8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TF	GPX8
Description		transferrin	glutathione peroxidase 8 (putative)
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endosome Early Endosome Late Endosome Endoplasmic Reticulum Lumen Plasma Membrane Clathrin-coated Pit Basal Plasma Membrane Cell Surface Endosome Membrane Membrane Apical Plasma Membrane Endocytic Vesicle Clathrin-coated Endocytic Vesicle Membrane Cytoplasmic Vesicle Vesicle Secretory Granule Lumen Basal Part Of Cell Perinuclear Region Of Cytoplasm Recycling Endosome Extracellular Exosome Blood Microparticle HFE-transferrin Receptor Complex	Endoplasmic Reticulum Lumen Membrane
	Molecular Function	Iron Ion Binding Protein Binding Ferrous Iron Binding Ferric Iron Binding Enzyme Binding Iron Chaperone Activity Transmembrane Transporter Binding Metal Ion Binding Transferrin Receptor Binding	Peroxidase Activity Glutathione Peroxidase Activity Protein Binding Oxidoreductase Activity
	Biological Process	Monoatomic Ion Transport Iron Ion Transport Intracellular Iron Ion Homeostasis Cell Surface Receptor Signaling Pathway Response To Bacterium Antibacterial Humoral Response Osteoclast Differentiation Regulation Of Protein Stability Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Receptor-mediated Endocytosis Multicellular Organismal-level Iron Ion Homeostasis Cellular Response To Iron Ion Iron Ion Export Across Plasma Membrane	Response To Oxidative Stress Cellular Response To Oxidative Stress Cellular Oxidant Detoxification
Pathways		Platelet degranulation Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Post-translational protein phosphorylation Iron uptake and transport Transferrin endocytosis and recycling	Detoxification of Reactive Oxygen Species
Drugs		Cisplatin Isoflurophate Aluminium Iron Zinc Manganese Copper Dichlorvos Zinc acetate Ferrous gluconate Ferrous succinate Ferrous ascorbate Ferrous fumarate Ferrous glycine sulfate Aluminium phosphate Aluminum acetate Zinc chloride Zinc sulfate, unspecified form	Glutathione Glutathione disulfide Benzoyl peroxide
Diseases
GWAS		Alcohol consumption (transferrin glycosylation) ( 21665994) HDL cholesterol levels ( 32203549) Hepcidin levels ( 21785125) Hereditary hemochromatosis-related traits (HFE mutation homozygotes) ( 25457201) Iron status biomarkers ( 21208937 21483845 25224454 19084217) Iron status biomarkers (iron levels) ( 28334935 33536631 25352340) Iron status biomarkers (total iron binding capacity) ( 33536631 28334935) Iron status biomarkers (transferrin levels) ( 25352340) Iron status biomarkers (transferrin saturation) ( 33536631 25352340 28334935) Mean corpuscular hemoglobin ( 29403010 32888494 27863252) Mean corpuscular hemoglobin concentration ( 29403010 32888494 27863252) Mean corpuscular volume ( 27863252 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Red blood cell count ( 32888494) Red cell distribution width ( 27863252 32888494)	Cocaine dependence ( 31212010)
Interacting Genes		47 interacting genes: AQP9 CALR CANX CLDN5 CPLX4 CUBN DRD2 ELOVL4 ERGIC3 FAM209A FAM210B FKBP7 GJB1 GOLM1 GPR42 GPX8 GRB2 HSD17B13 HSP90AA1 IGF1 IGF2 IGFBP1 IGFBP2 IGFBP3 IGFBP4 IGFBP5 IGFBP6 LAMC3 LCOR LEUTX PGRMC2 RMDN3 RSPH1 SH3BP2 SLC10A6 SLC26A6 SLC35H1 SMAD3 SORT1 SPINT1 SYT2 TFR2 TFRC TIMELESS TMEM52B TUBB3 VKORC1	170 interacting genes: AGTRAP AIG1 ALG8 ANKRD46 APOC3 APOD AQP1 AQP2 AQP3 ARLN ASGR1 ASPH BCL2L2 BET1 BIK BMP10 BNIP2 BTN2A2 C14orf180 C1GALT1 C3orf52 CACNG1 CCDC167 CD302 CD53 CD81 CDIPT CDS2 CFHR5 CHST1 CLDN19 CLDND2 CLEC1A CLEC2A CMTM5 CNIH1 CNIH3 COL4A5 COL8A2 CORIN CXCL16 CYB561 CYB561A3 CYB561D2 CYBC1 DNAJC30 DOLK EDDM3B ERG28 ERO1A FA2H FAM3C FAXDC2 GET3 GIMAP1 GOSR2 GPR151 GPR37L1 GRINA GYPA HHATL HMOX2 IGFBP5 INSIG2 ITGAM KIR2DL3 KLRG1 LAPTM4B LEPROTL1 LHFPL5 LNPEP LPAR3 MAN2B2 MARCHF2 MARCHF5 MFSD6 MGST2 MGST3 MIP MMD MYADML2 NEU1 NINJ1 NINJ2 NIPAL3 NKG7 NRM OCLN PAEP PAQR5 PAQR6 PGAP2 PLLP PLN PLP2 PLPP4 PLPP6 PMP22 PNLIPRP1 PRB1 RBFA RND1 RPRM RTP2 SCARB2 SCARF1 SCD SEC22B SELENOK SERINC1 SERINC2 SERP1 SERTM1 SFTPC SGMS2 SLC13A3 SLC30A3 SLC34A3 SLC35A1 SLC35B4 SLC38A7 SLC41A2 SLC61A1 SMAGP SNORC ST6GAL2 STX3 STX8 SYT15 SYT15B TF THBD TIMMDC1 TM4SF4 TMBIM6 TMEM107 TMEM109 TMEM11 TMEM120B TMEM128 TMEM14B TMEM14C TMEM19 TMEM203 TMEM218 TMEM229B TMEM243 TMEM254 TMEM42 TMEM50B TMEM60 TMEM86A TMEM86B TMEM97 TMPRSS4 TMUB2 TRAM1L1 TSPAN33 TSPO2 UNC50 UPK1B VAMP3 VAMP4 VAMP5 VKORC1L1 VSTM1 VTI1B YIF1A YIPF6 ZDHHC22
Entrez ID		7018	493869
HPRD ID		01811	17416
Ensembl ID		ENSG00000091513	ENSG00000164294
Uniprot IDs		A0PJA6 P02787 Q06AH7	B4DPY0 E7ETY7 J3KNB5 Q8TED1
PDB IDs		1A8E 1A8F 1B3E 1BP5 1BTJ 1D3K 1D4N 1DTG 1FQE 1FQF 1JQF 1N7W 1N7X 1N84 1OQG 1OQH 1RYO 1SUV 2HAU 2HAV 2O7U 2O84 3FGS 3QYT 3S9L 3S9M 3S9N 3SKP 3V83 3V89 3V8X 3VE1 4H0W 4X1B 4X1D 5DYH 5H52 5WTD 5X5P 5Y6K 6CTC 6D03 6D04 6D05 6JAS 6SOY 6SOZ 6UJ6 7FFM 7FFU 7Q1L 8BRC 9H49 9H4V	3CYN 3KIJ
Enriched GO Terms of Interacting Partners?		Insulin-like Growth Factor II Binding Insulin-like Growth Factor Binding Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Insulin-like Growth Factor I Binding Growth Factor Binding Endoplasmic Reticulum Lumen Insulin-like Growth Factor Binding Protein Complex Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Insulin-like Growth Factor Ternary Complex Type B Pancreatic Cell Proliferation Striated Muscle Cell Differentiation Osteoblast Differentiation Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Growth Transferrin Receptor Activity Receptor-mediated Endocytosis Muscle Cell Differentiation Regulation Of Cell Growth Response To Estradiol Positive Regulation Of Activated T Cell Proliferation Insulin Receptor Signaling Pathway Fibronectin Binding Morphogenesis Of A Branching Structure Intracellular Chemical Homeostasis Response To Iron Ion Cellular Developmental Process Epithelial Cell Proliferation Regulation Of Glucose Metabolic Process Protein Binding Positive Regulation Of Cellular Component Organization Developmental Process Endocytosis Regulation Of Activated T Cell Proliferation Positive Regulation Of T Cell Proliferation HFE-transferrin Receptor Complex Carbohydrate Transmembrane Transport Polyol Transmembrane Transport Iron Ion Transport Carbohydrate Transport Cellular Homeostasis Branching Involved In Labyrinthine Layer Morphogenesis Exocrine Pancreas Development Positive Regulation Of Transport Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Cell Population Proliferation Positive Regulation Of Cell Adhesion Transferrin Transport Brush Border Membrane Chemical Homeostasis Protein Folding In Endoplasmic Reticulum	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Protein Binding Plasma Membrane SNAP Receptor Activity SNARE Complex Golgi Membrane Cholesterol Binding Water Channel Activity Glycerol Transmembrane Transport Transmembrane Transport Channel Activity Renal Water Transport Polyol Transmembrane Transport Glycerol Transmembrane Transporter Activity Vesicle-mediated Transport Lysosomal Membrane Presynaptic Endosome Membrane Alkenylglycerophosphocholine Hydrolase Activity Water Transport Golgi Apparatus Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Lipid Metabolic Process Cellular Response To Mercury Ion Ascorbate Homeostasis ER To Golgi Transport Vesicle Membrane Endomembrane System Lysosome Organelle Fusion Fluid Transport Vesicle Fusion SNARE Binding Carbohydrate Binding Transmembrane Monodehydroascorbate Reductase Activity Membrane Destabilizing Activity Compact Myelin Transmembrane Ascorbate Ferrireductase Activity Respiratory Burst After Phagocytosis Organelle Membrane Fusion Monoatomic Ion Transport Sterol Biosynthetic Process Renal Water Homeostasis Metal Ion Transport Negative Regulation Of Lipoprotein Metabolic Process Water Transmembrane Transporter Activity Late Endosome Membrane Leukotriene-C4 Synthase Activity Membrane Fusion
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