CFH and CFI

Number of citations of the paper that reports this interaction (PubMedID 9291131)
41

Data Source:
HPRD (in vitro)

		CFH	CFI
Description		complement factor H	complement factor I
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Exosome Blood Microparticle Symbiont Cell Surface Serine-type Endopeptidase Complex	Extracellular Region Extracellular Space Membrane Extracellular Exosome
	Molecular Function	Complement Component C3b Binding Protein Binding Heparin Binding Identical Protein Binding Heparan Sulfate Proteoglycan Binding	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Metal Ion Binding
	Biological Process	Immune System Process Proteolysis Complement Activation Complement Activation, Alternative Pathway Regulation Of Complement Activation Regulation Of Complement Activation, Alternative Pathway Innate Immune Response Regulation Of Complement-dependent Cytotoxicity	Immune System Process Proteolysis Complement Activation Complement Activation, Classical Pathway Innate Immune Response
Pathways		Regulation of Complement cascade	Regulation of Complement cascade
Drugs		Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Zinc Copper Zinc acetate
Diseases		Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA) Alternative complement pathway component defects, including the following four diseases: Factor B deficiency; Factor D deficiency; Factor H deficiency; Properdin deficiency Familial flecked retina syndrome, including: Doyne honeycomb degeneration of retina (DHRD); Basal laminar drusen (BLD); Fundus albipunctatus (FA); Retinitis punctata albescens (RPA); Bietti crystalline corneoretinal dystrophy (BCD)	Complement regulatory protein defects, including the following six diseases: C1 inhibitor deficiency (hereditary angioedema); C4 binding protein alpha deficiency; C4 binding protein beta deficiency; Factor I deficiency; Decay-accelerating factor (CD55) deficiency; CD59 deficiency
GWAS		Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration ( 20385819 32741009 23577725 23536807 23455636 23326517 22694956 21665990 20861866 15761122 20385826) Age-related macular degeneration (choroidal neovascularisation) ( 22705344) Age-related macular degeneration (extreme sampling) ( 23577725) Age-related macular degeneration (geographic atrophy) ( 22705344) Age-related macular degeneration (MTAG) ( 32277175) Aspartate aminotransferase levels ( 33547301) Chronic central serous retinopathy ( 30073298 30480742) Circulating myeloperoxidase levels (serum) ( 23620142) Complement C3 and C4 levels ( 23028341) Complement C3 levels ( 33941608) Complement factor H binding to malondialdehyde ( 32321835) Complement factor H levels ( 34260947) Complement factor H-related protein 2 levels ( 34260947) Complement factor H-related protein 3 levels ( 34260947) Complement factor H-related protein 4A levels ( 34260947) Complement factor H-related protein 5 levels ( 34260947) Disease progression in age-related macular degeneration ( 29346644) Disease progression to choroidal neovascularization form in age-related macular degeneration ( 29346644) Disease progression to geographic atrophy form in age-related macular degeneration ( 29346644) Early age-related macular degeneration ( 32843070) Exudative age-related macular degeneration ( 25629512) Fuchs's corneal dystrophy ( 28358029) Liver enzyme levels (alanine transaminase) ( 33972514) Matrix metalloproteinase-8 levels ( 29212897) Meningococcal disease ( 20694013) Neovascular age-related macular degeneration ( 28703135) Nephropathy ( 21399633) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Rheumatic heart disease ( 34106200) Serum C3d:C3 ratio (systemic complement activation) ( 29398083) Sub-foveal choroidal thickness ( 29844195) Systemic lupus erythematosus ( 28714469) Waist-to-hip ratio adjusted for BMI ( 34021172)	Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration ( 20385819 20385826 21665990 23455636) Age-related macular degeneration (geographic atrophy) ( 22705344) Blood protein levels ( 30072576) Fasting insulin (dietary factor interaction) ( 24204828) Homeostasis model assessment of insulin resistance (dietary factor interaction) ( 24204828) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Serum alkaline phosphatase levels ( 33339817)
Interacting Genes		19 interacting genes: ADM C3 CFHR1 CFI CRP DMP1 DYRK1A EP300 GRB2 ITGAM LCOR PTX3 RSPH1 SELL SMAD3 THBS1 VDR YTHDC1 ZBTB16	3 interacting genes: C3 CFH GLP1R
Entrez ID		3075	3426
HPRD ID		00601	01955
Ensembl ID		ENSG00000000971	ENSG00000205403
Uniprot IDs		A0A0D9SG88 P08603	A8K3L0 B4DRF2 E7ETH0 G3XAM2 P05156 Q8WW88
PDB IDs		1HAQ 1HCC 1HFH 1HFI 2BZM 2G7I 2IC4 2JGW 2JGX 2KMS 2QFG 2QFH 2RLP 2RLQ 2UWN 2V8E 2W80 2W81 2WII 2XQW 3GAU 3GAV 3GAW 3KXV 3KZJ 3OXU 3R62 3RJ3 3SW0 4AYD 4AYE 4AYI 4AYM 4B2R 4B2S 4J38 4K12 4ONT 4ZH1 5NBQ 5O32 5O35 5WTB 6ATG 6ZH1 7WKI 7ZJM 9F7I	2XRC 5O32
Enriched GO Terms of Interacting Partners?		Immune Response Immune System Process Defense Response Defense Response To Other Organism Defense Response To Symbiont Opsonization Positive Regulation Of Reactive Oxygen Species Metabolic Process Response To Other Organism Immune Effector Process Vertebrate Eye-specific Patterning Response To External Biotic Stimulus Activation Of Immune Response Positive Regulation Of Immune System Process Complement-mediated Synapse Pruning Regionalization Extracellular Space Regulation Of Reactive Oxygen Species Metabolic Process Response To Stress Regulation Of Immune System Process Transcription Corepressor Binding Complement Activation Positive Regulation Of Ossification Complement Component C1q Complex Binding Positive Regulation Of Metabolic Process Branching Involved In Labyrinthine Layer Morphogenesis Regulation Of Immune Response Innate Immune Response Synapse Pruning Virion Binding Pattern Specification Process Positive Regulation Of Immune Response Complement Component C3b Binding Regulation Of Multicellular Organismal Development Complement Receptor Mediated Signaling Pathway Response To Yeast Immune Response-activating Cell Surface Receptor Signaling Pathway Humoral Immune Response Low-density Lipoprotein Particle Binding Regulation Of Cell Adhesion Positive Regulation Of Cell Adhesion Positive Regulation Of Biosynthetic Process Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Gene Expression Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Chondrocyte Differentiation Inflammatory Response Regulation Of Superoxide Anion Generation	Complement Activation, Alternative Pathway Regulation Of Complement Activation Symbiont Cell Surface Regulation Of Humoral Immune Response Complement Activation C5L2 Anaphylatoxin Chemotactic Receptor Binding Blood Microparticle Glucagon-like Peptide 1 Receptor Activity Positive Regulation Of Activation Of Membrane Attack Complex Complement-dependent Cytotoxicity Oviduct Epithelium Development Classical-complement-pathway C3/C5 Convertase Complex Positive Regulation Of Type IIa Hypersensitivity Humoral Immune Response Complement-mediated Synapse Pruning Vertebrate Eye-specific Patterning Glucagon Receptor Activity Response To Psychosocial Stress Regulation Of Complement Activation, Alternative Pathway Positive Regulation Of Complement Activation Complement Activation, Lectin Pathway Positive Regulation Of Hypersensitivity Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Complement Activation, GZMK Pathway Activation Of Membrane Attack Complex Regulation Of Apoptotic Cell Clearance Immune Effector Process Neuron Remodeling Positive Regulation Of Inflammatory Response To Antigenic Stimulus Synapse Pruning Activation Of Immune Response Positive Regulation Of Apoptotic Cell Clearance Positive Regulation Of Phagocytosis, Engulfment Complement Receptor Mediated Signaling Pathway Post-translational Protein Targeting To Membrane, Translocation Cellular Response To Glucagon Stimulus Activation Of Adenylate Cyclase Activity Serine-type Endopeptidase Complex Regulation Of Complement-dependent Cytotoxicity Complement Component C3b Binding Regulation Of Acute Inflammatory Response To Antigenic Stimulus Opsonization Positive Regulation Of Adenylate Cyclase Activity Heparan Sulfate Proteoglycan Binding Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Lyase Activity Response To Glucagon Positive Regulation Of Humoral Immune Response Positive Regulation Of Lipid Storage Positive Regulation Of Cyclase Activity
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