CFH and CRP

Number of citations of the paper that reports this interaction (PubMedID 10490997)
0

Data Source:
HPRD (in vitro, in vivo)

		CFH	CRP
Description		complement factor H	C-reactive protein
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Exosome Blood Microparticle Symbiont Cell Surface Serine-type Endopeptidase Complex	Extracellular Region Extracellular Space
	Molecular Function	Complement Component C3b Binding Protein Binding Heparin Binding Identical Protein Binding Heparan Sulfate Proteoglycan Binding	Complement Component C1q Complex Binding Calcium Ion Binding Protein Binding Low-density Lipoprotein Particle Binding Choline Binding Identical Protein Binding Virion Binding Metal Ion Binding Low-density Lipoprotein Particle Receptor Binding
	Biological Process	Immune System Process Proteolysis Complement Activation Complement Activation, Alternative Pathway Regulation Of Complement Activation Regulation Of Complement Activation, Alternative Pathway Innate Immune Response Regulation Of Complement-dependent Cytotoxicity	Acute-phase Response Inflammatory Response Opsonization Positive Regulation Of Gene Expression Negative Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Lipid Storage Regulation Of Interleukin-8 Production Positive Regulation Of Superoxide Anion Generation Negative Regulation Of Mononuclear Cell Proliferation Vasoconstriction Innate Immune Response Defense Response To Gram-positive Bacterium
Pathways		Regulation of Complement cascade	Classical antibody-mediated complement activation
Drugs		Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form	N,N,N-Trimethyl-2-(phosphonooxy)ethanaminium CRx-139
Diseases		Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA) Alternative complement pathway component defects, including the following four diseases: Factor B deficiency; Factor D deficiency; Factor H deficiency; Properdin deficiency Familial flecked retina syndrome, including: Doyne honeycomb degeneration of retina (DHRD); Basal laminar drusen (BLD); Fundus albipunctatus (FA); Retinitis punctata albescens (RPA); Bietti crystalline corneoretinal dystrophy (BCD)	Systemic lupus erythematosus
GWAS		Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration ( 20385819 32741009 23577725 23536807 23455636 23326517 22694956 21665990 20861866 15761122 20385826) Age-related macular degeneration (choroidal neovascularisation) ( 22705344) Age-related macular degeneration (extreme sampling) ( 23577725) Age-related macular degeneration (geographic atrophy) ( 22705344) Age-related macular degeneration (MTAG) ( 32277175) Aspartate aminotransferase levels ( 33547301) Chronic central serous retinopathy ( 30073298 30480742) Circulating myeloperoxidase levels (serum) ( 23620142) Complement C3 and C4 levels ( 23028341) Complement C3 levels ( 33941608) Complement factor H binding to malondialdehyde ( 32321835) Complement factor H levels ( 34260947) Complement factor H-related protein 2 levels ( 34260947) Complement factor H-related protein 3 levels ( 34260947) Complement factor H-related protein 4A levels ( 34260947) Complement factor H-related protein 5 levels ( 34260947) Disease progression in age-related macular degeneration ( 29346644) Disease progression to choroidal neovascularization form in age-related macular degeneration ( 29346644) Disease progression to geographic atrophy form in age-related macular degeneration ( 29346644) Early age-related macular degeneration ( 32843070) Exudative age-related macular degeneration ( 25629512) Fuchs's corneal dystrophy ( 28358029) Liver enzyme levels (alanine transaminase) ( 33972514) Matrix metalloproteinase-8 levels ( 29212897) Meningococcal disease ( 20694013) Neovascular age-related macular degeneration ( 28703135) Nephropathy ( 21399633) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Rheumatic heart disease ( 34106200) Serum C3d:C3 ratio (systemic complement activation) ( 29398083) Sub-foveal choroidal thickness ( 29844195) Systemic lupus erythematosus ( 28714469) Waist-to-hip ratio adjusted for BMI ( 34021172)	Blood protein levels ( 30072576 23696881) C-reactive protein ( 18439548 18439552 23844046 19567438 21196492 21647738 22492993 22939635) C-reactive protein levels ( 28548082 24763700 29403010 29878111 30388399 33227023 33339817 21300955) C-reactive protein levels in ischemic stroke ( 26718567) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Erythropoietin levels ( 33227023) High-sensitivity C-reactive protein levels in HIV infection ( 33095540) Inflammatory biomarkers ( 22291609) Inflammatory biomarkers in Kawasaki disease ( 25266886) Lung cancer ( 18385676) Metabolic traits ( 19060910) Protein quantitative trait loci ( 18464913) Select biomarker traits ( 17903293) Serum C-reactive protein concentration ( 32928877) Serum C-reactive protein concentration in obesity ( 32928877) Serum C-reactive protein concentration in visceral obesity (waist circumference) ( 32928877)
Interacting Genes		19 interacting genes: ADM C3 CFHR1 CFI CRP DMP1 DYRK1A EP300 GRB2 ITGAM LCOR PTX3 RSPH1 SELL SMAD3 THBS1 VDR YTHDC1 ZBTB16	22 interacting genes: APCS C1QA CFH ESS2 FCGR1A FCGR2A FCGR2B FN1 GLUD1 GMPPA GP6 H1-1 H2AC16 H2AC20 LAMC3 LEP MAPK1 MAPK3 MAPK8IP2 RPL13A SNRNP70 UBE3A
Entrez ID		3075	1401
HPRD ID		00601	00422
Ensembl ID		ENSG00000000971	ENSG00000132693
Uniprot IDs		A0A0D9SG88 P08603	P02741 Q5VVP7
PDB IDs		1HAQ 1HCC 1HFH 1HFI 2BZM 2G7I 2IC4 2JGW 2JGX 2KMS 2QFG 2QFH 2RLP 2RLQ 2UWN 2V8E 2W80 2W81 2WII 2XQW 3GAU 3GAV 3GAW 3KXV 3KZJ 3OXU 3R62 3RJ3 3SW0 4AYD 4AYE 4AYI 4AYM 4B2R 4B2S 4J38 4K12 4ONT 4ZH1 5NBQ 5O32 5O35 5WTB 6ATG 6ZH1 7WKI 7ZJM 9F7I	1B09 1GNH 1LJ7 3L2Y 3PVN 3PVO 7PK9 7PKB 7PKD 7PKE 7PKF 7PKG 7PKH 7TBA 8WV4 8WV5
Enriched GO Terms of Interacting Partners?		Immune Response Immune System Process Defense Response Defense Response To Other Organism Defense Response To Symbiont Opsonization Positive Regulation Of Reactive Oxygen Species Metabolic Process Response To Other Organism Immune Effector Process Vertebrate Eye-specific Patterning Response To External Biotic Stimulus Activation Of Immune Response Positive Regulation Of Immune System Process Complement-mediated Synapse Pruning Regionalization Extracellular Space Regulation Of Reactive Oxygen Species Metabolic Process Response To Stress Regulation Of Immune System Process Transcription Corepressor Binding Complement Activation Positive Regulation Of Ossification Complement Component C1q Complex Binding Positive Regulation Of Metabolic Process Branching Involved In Labyrinthine Layer Morphogenesis Regulation Of Immune Response Innate Immune Response Synapse Pruning Virion Binding Pattern Specification Process Positive Regulation Of Immune Response Complement Component C3b Binding Regulation Of Multicellular Organismal Development Complement Receptor Mediated Signaling Pathway Response To Yeast Immune Response-activating Cell Surface Receptor Signaling Pathway Humoral Immune Response Low-density Lipoprotein Particle Binding Regulation Of Cell Adhesion Positive Regulation Of Cell Adhesion Positive Regulation Of Biosynthetic Process Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Gene Expression Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Chondrocyte Differentiation Inflammatory Response Regulation Of Superoxide Anion Generation	IgG Binding Acute Inflammatory Response IgG Receptor Activity Regulation Of Immune System Process Antibody-dependent Cellular Cytotoxicity Hypersensitivity Acute Inflammatory Response To Antigenic Stimulus Regulation Of Immune Response Interleukin-34-mediated Signaling Pathway Lung Morphogenesis Fc-gamma Receptor Signaling Pathway Endocytosis Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Positive Regulation Of Tumor Necrosis Factor Production Inflammatory Response To Antigenic Stimulus Regulation Of Stress-activated MAPK Cascade Caveolin-mediated Endocytosis Regulation Of Golgi Inheritance Positive Regulation Of Macrophage Proliferation Regulation Of Stress-activated Protein Kinase Signaling Cascade Immunoglobulin Mediated Immune Response Positive Regulation Of Immune System Process Regulation Of Leukocyte Proliferation Regulation Of Acute Inflammatory Response B Cell Mediated Immunity Cardiac Neural Crest Cell Development Involved In Heart Development Trachea Formation Positive Regulation Of Endocytosis Fc Receptor Signaling Pathway Regulation Of Vesicle-mediated Transport Regulation Of Defense Response Outer Ear Morphogenesis ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Positive Regulation Of Leukocyte Proliferation Regulation Of Tumor Necrosis Factor Production Bergmann Glial Cell Differentiation Glial Cell Development Import Into Cell Negative Regulation Of Acute Inflammatory Response Regulation Of Lymphocyte Mediated Immunity Immune Effector Process Positive Regulation Of Phagocytosis Leukocyte Mediated Cytotoxicity Regulation Of Cell Activation Response To External Biotic Stimulus Regulation Of MAPK Cascade Regulation Of Natural Killer Cell Proliferation Immune Response-regulating Signaling Pathway Regulation Of Inflammatory Response
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