FOLH1

Description		folate hydrolase 1
Image
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Cell Surface Membrane Extracellular Exosome
	Molecular Function	Catalytic Activity Carboxypeptidase Activity Metallocarboxypeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Hydrolase Activity Dipeptidase Activity Metal Ion Binding Ac-Asp-Glu Binding Tetrahydrofolyl-poly(glutamate) Polymer Binding
	Biological Process	Proteolysis Glutamate Biosynthetic Process Folic Acid-containing Compound Metabolic Process Intestinal Folate Absorption Positive Regulation Of Glutamate Receptor Signaling Pathway
Pathways		Aspartate and asparagine metabolism
Drugs		Capromab pendetide Glutamic acid (2S)-2-{[HYDROXY(4-IODOBENZYL)PHOSPHORYL]METHYL}PENTANEDIOIC ACID DCFBC Spaglumic acid Piflufolastat F 18
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Blood protein levels ( 30072576) Body size at age 10 ( 32376654) Fasting glucose ( 34059833) Feeling fed-up ( 29500382) HDL cholesterol ( 19060911) HDL cholesterol levels ( 32203549) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Height ( 20881960) Intraocular pressure ( 29617998) Serum metabolite concentrations in chronic kidney disease ( 33838163) Serum metabolite levels ( 33031748) Systolic blood pressure ( 30578418) Systolic blood pressure x dichotomous lifestyle risk score interaction (2df test) ( 32227373) Urinary metabolite levels in chronic kidney disease ( 31959995)
Interacting Genes		4 interacting genes: C3orf52 LCOR MTAP RPS3
Entrez ID		2346
HPRD ID		02961
Ensembl ID		ENSG00000086205
Uniprot IDs		Q04609
PDB IDs		1Z8L 2C6C 2C6G 2C6P 2CIJ 2JBJ 2JBK 2OOT 2OR4 2PVV 2PVW 2XEF 2XEG 2XEI 2XEJ 3BHX 3BI0 3BI1 3BXM 3D7D 3D7F 3D7G 3D7H 3IWW 3RBU 3SJE 3SJF 3SJG 3SJX 4JYW 4JZ0 4LQG 4MCP 4MCQ 4MCR 4MCS 4NGM 4NGN 4NGP 4NGQ 4NGR 4NGS 4NGT 4OC0 4OC1 4OC2 4OC3 4OC4 4OC5 4OME 4P44 4P45 4P4B 4P4D 4P4E 4P4F 4P4I 4P4J 4W9Y 4X3R 5D29 5ELY 5F09 5O5R 5O5T 5O5U 5OF0 6ETY 6EZ9 6F5L 6FE5 6H7Y 6H7Z 6HKJ 6HKZ 6RBC 6RTI 6S1X 6SGP 6SKH 7BFZ 8BO8 8BOL 8BOW
Enriched GO Terms of Interacting Partners?		Nicotinamide Riboside Catabolic Process S-methyl-5-thioadenosine Phosphorylase Activity Positive Regulation Of Base-excision Repair Response To TNF Agonist Oxidized Pyrimidine DNA Binding Purine Ribonucleoside Salvage L-methionine Salvage From Methylthioadenosine L-methionine Salvage Pentosyltransferase Activity 1,4-alpha-oligoglucan Phosphorylase Activity Oxidized Purine DNA Binding Regulation Of Endodeoxyribonuclease Activity Positive Regulation Of Deoxyribonuclease Activity Ubiquitin-like Protein Conjugating Enzyme Binding Supercoiled DNA Binding Class I DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Positive Regulation Of Endodeoxyribonuclease Activity Small Ribosomal Subunit RRNA Binding NF-kappaB Complex Regulation Of Base-excision Repair DNA N-glycosylase Activity Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Methionine Biosynthetic Process Nucleoside Salvage DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Nucleobase-containing Small Molecule Catabolic Process Methionine Metabolic Process Histone Methyltransferase Binding Sulfur Amino Acid Biosynthetic Process Positive Regulation Of T Cell Receptor Signaling Pathway Ubiquitin-specific Protease Binding DNA Endonuclease Activity Protein Kinase A Binding Purine Nucleoside Metabolic Process Small Ribosomal Subunit Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of Antigen Receptor-mediated Signaling Pathway Purine-containing Compound Salvage Positive Regulation Of Microtubule Polymerization Sulfur Amino Acid Metabolic Process Base-excision Repair Cellular Response To Estradiol Stimulus Response To Testosterone Cytosolic Small Ribosomal Subunit Positive Regulation Of Interleukin-2 Production Hsp90 Protein Binding Nuclear Estrogen Receptor Binding Aspartate Family Amino Acid Metabolic Process Regulation Of Activated T Cell Proliferation Negative Regulation Of DNA Repair
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