FOLH1 and MTAP

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		FOLH1	MTAP
Gene Name		folate hydrolase (prostate-specific membrane antigen) 1	methylthioadenosine phosphorylase
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Integral Component Of Plasma Membrane Membrane Extracellular Vesicular Exosome	Nucleus Cytoplasm Cytosol Extracellular Vesicular Exosome
	Molecular Function	Carboxypeptidase Activity Peptidase Activity Metallopeptidase Activity Dipeptidase Activity Metal Ion Binding	Phosphorylase Activity S-methyl-5-thioadenosine Phosphorylase Activity
	Biological Process	Proteolysis Folic Acid-containing Compound Metabolic Process	Sulfur Amino Acid Metabolic Process Nucleobase-containing Compound Metabolic Process Purine Ribonucleoside Salvage Polyamine Metabolic Process Nicotinamide Riboside Catabolic Process L-methionine Biosynthetic Process From Methylthioadenosine Methylation Response To Testosterone Cellular Nitrogen Compound Metabolic Process Small Molecule Metabolic Process
Pathways			Metabolism of polyamines Sulfur amino acid metabolism Methionine salvage pathway Metabolism of amino acids and derivatives
Drugs		Capromab L-Glutamic Acid (2S)-2-{[HYDROXY(4-IODOBENZYL)PHOSPHORYL]METHYL}PENTANEDIOIC ACID N-({(1R)-1-carboxy-2-[(4-fluorobenzyl)sulfanyl]ethyl}carbamoyl)-L-glutamic acid	Adenine (1s)-1-(9-Deazaadenin-9-Yl)-1,4,5-Trideoxy-1,4-Imino-5-Methylthio-D-Ribitol Formycin 5\'-Deoxy-5\'-Methylthioadenosine 5\'-Deoxy-5\'-(Methylthio)-Tubercidin
Diseases
GWAS		HDL cholesterol ( 19060911) Height ( 20881960)	Coronary heart disease ( 21606135) Cutaneous nevi ( 19578365) Melanoma ( 21983787)
Protein-Protein Interactions		2 interactors: MTAP RPS3	6 interactors: CDC25A CENPH FOLH1 LYRM1 MYLIP RELB
Entrez ID		2346	4507
HPRD ID		02961	01134
Ensembl ID		ENSG00000086205	ENSG00000099810
Uniprot IDs		Q04609	B4DUC8 Q13126
PDB IDs		1Z8L 2C6C 2C6G 2C6P 2CIJ 2JBJ 2JBK 2OOT 2OR4 2PVV 2PVW 2XEF 2XEG 2XEI 2XEJ 3BHX 3BI0 3BI1 3BXM 3D7D 3D7F 3D7G 3D7H 3IWW 3RBU 3SJE 3SJF 3SJG 3SJX	1CB0 1CG6 1K27 1SD1 1SD2 3LN5 3OZC 3OZD 3OZE
Enriched GO Terms of Interacting Partners?		Positive Regulation Of DNA N-glycosylase Activity Purine Ribonucleoside Salvage Negative Regulation Of DNA Repair L-methionine Biosynthetic Process From Methylthioadenosine L-methionine Salvage Cytoplasmic Translation Methionine Biosynthetic Process Methionine Metabolic Process Sulfur Amino Acid Biosynthetic Process Purine-containing Compound Salvage Polyamine Metabolic Process Response To Testosterone Sulfur Amino Acid Metabolic Process Regulation Of DNA Repair
Tagcloud ?		adam adam17 basing cav1 cav2 cdc42 coexpressed dusp dusp6 fgfr3 flt4 her3 kdr krt18 krt8 lck macroglobulin mmp9 neoangiogenesis pdgfb psm ptk ptp ptpns1 ptprs top2 top2a vav1 vim	9p 9p21 abilities accounts aggressiveness alanosine anchorage attributable confers hemizygous homozygous immunoexpression inactivated losses methylthioadenosine myxofibrosarcoma myxofibrosarcomas pathogenically phosphorylase portended preserved recurrently reexpressing reexpression reverted spanning umbilical unfavorable xenografts
Tagcloud (Difference) ?		adam adam17 basing cav1 cav2 cdc42 coexpressed dusp dusp6 fgfr3 flt4 her3 kdr krt18 krt8 lck macroglobulin mmp9 neoangiogenesis pdgfb psm ptk ptp ptpns1 ptprs top2 top2a vav1 vim	9p 9p21 abilities accounts aggressiveness alanosine anchorage attributable confers hemizygous homozygous immunoexpression inactivated losses methylthioadenosine myxofibrosarcoma myxofibrosarcomas pathogenically phosphorylase portended preserved recurrently reexpressing reexpression reverted spanning umbilical unfavorable xenografts
Tagcloud (Intersection) ?