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L3MBTL3 and LRRK2
Number of citations of the paper that reports this interaction (PMID
19001729
)
2
Data Source:
BioGRID
(two hybrid)
L3MBTL3
LRRK2
Gene Name
l(3)mbt-like 3 (Drosophila)
leucine-rich repeat kinase 2
Image
Gene Ontology Annotations
Cellular Component
Nucleus
Extracellular Space
Cytoplasm
Mitochondrion
Mitochondrial Outer Membrane
Mitochondrial Inner Membrane
Mitochondrial Matrix
Lysosome
Endosome
Endoplasmic Reticulum
Golgi Apparatus
Trans-Golgi Network
Cytosol
Plasma Membrane
Synaptic Vesicle
Inclusion Body
Axon
Dendrite
Cytoplasmic Vesicle
Mitochondrial Membrane
Cytoplasmic Side Of Mitochondrial Outer Membrane
Dendrite Cytoplasm
Neuron Projection
Neuronal Cell Body
Terminal Bouton
Perikaryon
Membrane Raft
Extracellular Vesicular Exosome
Molecular Function
Molecular_function
SNARE Binding
Glycoprotein Binding
Actin Binding
GTPase Activity
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
MAP Kinase Kinase Activity
GTPase Activator Activity
Protein Binding
ATP Binding
GTP Binding
Tubulin Binding
Kinase Activity
Rho GTPase Binding
Syntaxin-1 Binding
Clathrin Binding
GTP-dependent Protein Kinase Activity
Peroxidase Inhibitor Activity
Identical Protein Binding
Protein Homodimerization Activity
Ion Channel Binding
Protein Kinase A Binding
Biological Process
Transcription, DNA-templated
Regulation Of Transcription, DNA-templated
Chromatin Modification
Macrophage Differentiation
Granulocyte Differentiation
Erythrocyte Maturation
MAPK Cascade
Activation Of MAPKK Activity
Activation Of MAPK Activity
Negative Regulation Of Protein Phosphorylation
Positive Regulation Of Protein Phosphorylation
Protein Phosphorylation
Endocytosis
Autophagy
Response To Oxidative Stress
Small GTPase Mediated Signal Transduction
Neuromuscular Junction Development
Determination Of Adult Lifespan
Positive Regulation Of Autophagy
Regulation Of Protein Kinase A Signaling
Negative Regulation Of Protein Processing
Regulation Of Neuron Maturation
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Olfactory Bulb Development
Tangential Migration From The Subventricular Zone To The Olfactory Bulb
Positive Regulation Of Protein Ubiquitination
Negative Regulation Of Protein Binding
Positive Regulation Of Protein Binding
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of GTPase Activity
Cellular Response To Oxidative Stress
Cellular Protein Localization
Intracellular Signal Transduction
Regulation Of Kidney Size
Exploration Behavior
Locomotory Exploration Behavior
Regulation Of Locomotion
Regulation Of Membrane Potential
Positive Regulation Of Programmed Cell Death
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of GTPase Activity
Protein Autophosphorylation
Intracellular Distribution Of Mitochondria
Neuron Projection Morphogenesis
Regulation Of Mitochondrial Depolarization
Regulation Of Synaptic Transmission, Glutamatergic
Regulation Of Excitatory Postsynaptic Membrane Potential
Regulation Of Dopamine Receptor Signaling Pathway
Positive Regulation Of Dopamine Receptor Signaling Pathway
Regulation Of Dendritic Spine Morphogenesis
Protein Localization To Mitochondrion
Neuron Death
Cellular Response To Manganese Ion
Reactive Oxygen Species Metabolic Process
Regulation Of Mitochondrial Fission
Regulation Of Neuron Death
Negative Regulation Of Neuron Death
Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Protein Autoubiquitination
Regulation Of Neuroblast Proliferation
Regulation Of Synaptic Vesicle Transport
Negative Regulation Of Late Endosome To Lysosome Transport
Negative Regulation Of Thioredoxin Peroxidase Activity By Peptidyl-threonine Phosphorylation
Negative Regulation Of Hydrogen Peroxide-induced Cell Death
Negative Regulation Of Protein Targeting To Mitochondrion
Negative Regulation Of Protein Processing Involved In Protein Targeting To Mitochondrion
Cellular Response To Dopamine
Regulation Of Branching Morphogenesis Of A Nerve
Regulation Of Synaptic Vesicle Exocytosis
Negative Regulation Of Peroxidase Activity
Pathways
Drugs
Diseases
GWAS
Height (
20881960
23563607
18391951
)
Crohn's disease (
18587394
21102463
)
Inflammatory bowel disease (
23128233
)
Obesity-related traits (
23251661
)
Parkinson's disease (
21292315
19915576
22438815
21738487
)
Protein-Protein Interactions
26 interactors:
ASB6
BANP
BYSL
KDM1A
LRRK2
LSM4
LZTR1
MAPK3
MAPK9
MORF4L1
MORF4L2
NGB
OAZ3
PDE6G
PHC2
PIK3R3
PLEKHF1
PLEKHF2
POLR2L
PRKAA1
PRKAA2
SNRPB
SP100
SUMO1P1
THRA
TTC19
33 interactors:
ACTB
AKT1
ARFGAP1
ARHGEF7
BAG5
DVL1
DVL2
DVL3
EIF4EBP1
HSPD1
L3MBTL3
LRP6
MAP1B
MAP2K3
MAP2K4
MAP2K6
MAP2K7
MAPT
MBP
PRKCZ
PTPN23
RALYL
RIPK2
SH3GL1
SH3GL2
SH3GL3
STK24
STK25
STK3
STRBP
TAOK3
TRAF2
TUBA1A
Entrez ID
84456
120892
HPRD ID
11222
10613
Ensembl ID
ENSG00000198945
ENSG00000188906
Uniprot IDs
Q96JM7
Q17RV3
Q5S007
PDB IDs
1WJQ
1WJS
3UT1
4FL6
4L59
2ZEJ
3D6T
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of Autophagy
Chromatin Modification
Positive Regulation Of Cellular Metabolic Process
Negative Regulation Of Binding
RNA Metabolic Process
Regulation Of Autophagy
Chromatin Organization
Transcription, DNA-templated
Positive Regulation Of Metabolic Process
RNA Biosynthetic Process
Regulation Of Lipid Metabolic Process
Cellular Response To Stress
Activation Of MAPK Activity
Insulin Receptor Signaling Pathway
Negative Regulation Of Protein Binding
Negative Regulation Of Transport
Chromosome Organization
Gene Expression
Positive Regulation Of MAP Kinase Activity
Cellular Response To Insulin Stimulus
Regulation Of Energy Homeostasis
Regulation Of Apoptotic Process
Positive Regulation Of Glycolytic Process
Negative Regulation Of Intracellular Protein Transport
Fatty Acid Homeostasis
Positive Regulation Of Gene Expression
Cellular Response To Organonitrogen Compound
Regulation Of Cell Death
Cellular Nitrogen Compound Metabolic Process
Regulation Of Binding
Regulation Of Circadian Rhythm
Organelle Organization
Response To Organonitrogen Compound
Regulation Of Metabolic Process
Activation Of Protein Kinase Activity
Positive Regulation Of G-protein Coupled Receptor Protein Signaling Pathway
Positive Regulation Of Protein Serine/threonine Kinase Activity
Nucleobase-containing Compound Metabolic Process
Regulation Of MAP Kinase Activity
Response To Insulin
Negative Regulation Of Intracellular Transport
Histone-serine Phosphorylation
Regulation Of Signal Transduction
Peptidyl-serine Phosphorylation
Regulation Of Intracellular Signal Transduction
Cellular Response To Peptide Hormone Stimulus
Cellular Response To Hormone Stimulus
Response To Stress
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Cellular Response To Glucose Starvation
Regulation Of Protein Kinase Activity
Positive Regulation Of Protein Kinase Activity
Regulation Of Kinase Activity
Positive Regulation Of Kinase Activity
Regulation Of Stress-activated MAPK Cascade
Positive Regulation Of Protein Serine/threonine Kinase Activity
Positive Regulation Of Transferase Activity
Positive Regulation Of Stress-activated MAPK Cascade
Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade
Positive Regulation Of MAPK Cascade
Regulation Of MAPK Cascade
Regulation Of JNK Cascade
Regulation Of Protein Phosphorylation
Positive Regulation Of Phosphorylation
Regulation Of Phosphorylation
Positive Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of JNK Cascade
Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of MAP Kinase Activity
Regulation Of Phosphorus Metabolic Process
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Signal Transduction
Intracellular Signal Transduction
Regulation Of Protein Metabolic Process
Positive Regulation Of Protein Modification Process
Anatomical Structure Development
Signal Transduction By Phosphorylation
Regulation Of Catalytic Activity
Regulation Of MAP Kinase Activity
Regulation Of Signal Transduction
Toll-like Receptor Signaling Pathway
Signaling
Regulation Of Intracellular Signal Transduction
Cell Communication
Positive Regulation Of Catalytic Activity
Positive Regulation Of Intracellular Signal Transduction
TRIF-dependent Toll-like Receptor Signaling Pathway
Signal Transduction
Cell Death
Death
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
MyD88-dependent Toll-like Receptor Signaling Pathway
Positive Regulation Of JUN Kinase Activity
Developmental Process
Regulation Of Signaling
Activation Of Innate Immune Response
Tagcloud
?
autosomal
decline
difficulty
dj1
england
g2019s
gait
gu
hoehn
idiopathic
leucine
motor
movement
parkinson
pd
pigd
pink1
postural
prkn
rating
schwab
snca
society
staging
udrs
undefined
unified
updrs
yahr
Tagcloud (Difference)
?
autosomal
decline
difficulty
dj1
england
g2019s
gait
gu
hoehn
idiopathic
leucine
motor
movement
parkinson
pd
pigd
pink1
postural
prkn
rating
schwab
snca
society
staging
udrs
undefined
unified
updrs
yahr
Tagcloud (Intersection)
?