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L3MBTL3 and MAPK3
Number of citations of the paper that reports this interaction (PubMedID
24722188
)
69
Data Source:
BioGRID
(two hybrid)
L3MBTL3
MAPK3
Description
L3MBTL histone methyl-lysine binding protein 3
mitogen-activated protein kinase 3
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Nucleolus
Nucleus
Nuclear Envelope
Nucleoplasm
Cytoplasm
Mitochondrion
Early Endosome
Late Endosome
Endoplasmic Reticulum Lumen
Golgi Apparatus
Cytosol
Cytoskeleton
Plasma Membrane
Caveola
Focal Adhesion
Cilium
Microtubule Cytoskeleton
Membrane
Pseudopodium
Ciliary Basal Body
Anchoring Junction
Glutamatergic Synapse
Molecular Function
Chromatin Binding
Protein Binding
Zinc Ion Binding
Histone Binding
Identical Protein Binding
Metal Ion Binding
Methylation-dependent Protein Binding
Nucleotide Binding
Phosphotyrosine Residue Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
MAP Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Phosphatase Binding
Identical Protein Binding
Protein Serine Kinase Activity
DNA-binding Transcription Factor Binding
Biological Process
Chromatin Organization
Regulation Of DNA-templated Transcription
Myeloid Cell Differentiation
Macrophage Differentiation
Granulocyte Differentiation
Erythrocyte Maturation
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Autophagosome Assembly
MAPK Cascade
Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell
DNA-templated Transcription
Protein Phosphorylation
Apoptotic Process
DNA Damage Response
Cell Surface Receptor Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
Insulin Receptor Signaling Pathway
Animal Organ Morphogenesis
Regulation Of Gene Expression
Negative Regulation Of Autophagy
Positive Regulation Of Autophagy
Positive Regulation Of Macrophage Chemotaxis
Neural Crest Cell Development
Schwann Cell Development
Phosphorylation
Sensory Perception Of Pain
Regulation Of Ossification
BMP Signaling Pathway
Regulation Of Cellular PH
Thyroid Gland Development
Positive Regulation Of Cyclase Activity
Lipopolysaccharide-mediated Signaling Pathway
Cellular Response To Nutrient Levels
Positive Regulation Of Telomere Maintenance
Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Response To Lipopolysaccharide
Regulation Of Stress-activated MAPK Cascade
Cellular Response To Amino Acid Starvation
Intracellular Signal Transduction
Peptidyl-tyrosine Autophosphorylation
ERBB2-ERBB3 Signaling Pathway
TORC1 Signaling
Outer Ear Morphogenesis
Myelination
Glucose Homeostasis
Signal Transduction In Response To DNA Damage
Response To Exogenous DsRNA
Positive Regulation Of Transcription By RNA Polymerase II
Insulin-like Growth Factor Receptor Signaling Pathway
Thymus Development
Modulation Of Chemical Synaptic Transmission
Protein Stabilization
Negative Regulation Of T Cell Activation
Cartilage Development
Stress-activated MAPK Cascade
Regulation Of Cytoskeleton Organization
Bergmann Glial Cell Differentiation
Face Development
Lung Morphogenesis
Trachea Formation
Cardiac Neural Crest Cell Development Involved In Heart Development
Interleukin-34-mediated Signaling Pathway
ERK1 And ERK2 Cascade
Positive Regulation Of ERK1 And ERK2 Cascade
Interleukin-1-mediated Signaling Pathway
Response To Epidermal Growth Factor
Cellular Response To Mechanical Stimulus
Cellular Response To Tumor Necrosis Factor
Caveolin-mediated Endocytosis
Regulation Of Golgi Inheritance
Negative Regulation Of Cholesterol Efflux
Xenophagy
Positive Regulation Of Macrophage Proliferation
Positive Regulation Of Neuroinflammatory Response
Negative Regulation Of TORC1 Signaling
Positive Regulation Of Xenophagy
Regulation Of Early Endosome To Late Endosome Transport
Pathways
MAPK3 (ERK1) activation
RAF-independent MAPK1/3 activation
ISG15 antiviral mechanism
Signaling by NODAL
Spry regulation of FGF signaling
Signaling by Activin
Frs2-mediated activation
ERK/MAPK targets
ERK/MAPK targets
ERKs are inactivated
Regulation of actin dynamics for phagocytic cup formation
Downregulation of SMAD2/3:SMAD4 transcriptional activity
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
Oncogene Induced Senescence
Oncogene Induced Senescence
FCERI mediated MAPK activation
Regulation of HSF1-mediated heat shock response
NCAM signaling for neurite out-growth
RSK activation
Signal transduction by L1
Activation of the AP-1 family of transcription factors
Thrombin signalling through proteinase activated receptors (PARs)
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
RHO GTPases Activate WASPs and WAVEs
RHO GTPases Activate NADPH Oxidases
RAF/MAP kinase cascade
MAP2K and MAPK activation
Negative feedback regulation of MAPK pathway
Negative regulation of MAPK pathway
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF1 fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
RNA Polymerase I Promoter Opening
Signal attenuation
Interferon gamma signaling
Advanced glycosylation endproduct receptor signaling
Gastrin-CREB signalling pathway via PKC and MAPK
ESR-mediated signaling
RUNX2 regulates osteoblast differentiation
Regulation of PTEN gene transcription
Regulation of the apoptosome activity
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Suppression of apoptosis
Signaling downstream of RAS mutants
Signaling by MAP2K mutants
Signaling by RAF1 mutants
FCGR3A-mediated phagocytosis
Nuclear events stimulated by ALK signaling in cancer
IFNG signaling activates MAPKs
Negative Regulation of CDH1 Gene Transcription
NPAS4 regulates expression of target genes
NPAS4 regulates expression of target genes
Growth hormone receptor signaling
Signaling by LTK in cancer
Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs
Sulindac
Acetylsalicylic acid
Minocycline
Arsenic trioxide
Colforsin
Purvalanol
5-iodotubercidin
Seliciclib
Cholecystokinin
Ulixertinib
Diseases
GWAS
A body shape index (
34021172
)
Alanine aminotransferase levels (
34315874
33547301
)
Apolipoprotein B levels (
32203549
)
Appendicular lean mass (
33097823
)
Aspartate aminotransferase levels (
34315874
33547301
)
Basophil count (
32888494
)
Basophil percentage of white cells (
32888494
)
Birth weight (
27680694
31043758
)
Body mass index (
25673413
)
Breast cancer (
29058716
29059683
)
Breast cancer (estrogen-receptor negative) (
29058716
)
C-reactive protein levels (
30388399
)
Chronic kidney disease (
31152163
)
Estimated glomerular filtration rate (
31152163
)
Heel bone mineral density (
30598549
28869591
)
Height (
20881960
31562340
18391951
23563607
25282103
28552196
25429064
)
Hematocrit (
27863252
32888494
)
Hemoglobin (
32888494
)
Hemoglobin levels (
32327693
)
High light scatter reticulocyte count (
32888494
)
High light scatter reticulocyte percentage of red cells (
32888494
)
Hip circumference (
25673412
)
Hip circumference adjusted for BMI (
34021172
25673412
28552196
)
Immature fraction of reticulocytes (
32888494
)
Influenza A (H1N1) infection (
26379185
)
LDL cholesterol levels (
32203549
)
Liver enzyme levels (alanine transaminase) (
33972514
)
Liver enzyme levels (alkaline phosphatase) (
33972514
)
Liver enzyme levels (gamma-glutamyl transferase) (
33972514
)
Low density lipoprotein cholesterol levels (
32154731
)
Lymphocyte count (
32888494
27863252
)
Mild influenza (H1N1) infection (
26379185
)
Multiple sclerosis (
31604244
27386562
)
Offspring birth weight (
31043758
)
Red blood cell count (
32888494
)
Reticulocyte count (
32888494
)
Spherical equivalent or myopia (age of diagnosis) (
29808027
)
Spleen volume (
34128465
)
Triglyceride levels (
32203549
32154731
)
Triglyceride levels in HIV infection (
33109212
)
Waist-hip index (
34021172
)
Waist-to-hip ratio adjusted for BMI (
34021172
)
Weight (
28552196
)
White blood cell count (
32888494
)
Autism spectrum disorder or schizophrenia (
28540026
)
Blood protein levels (
30072576
)
Brain morphology (MOSTest) (
32665545
)
Childhood body mass index (
33045005
)
Hodgkin's lymphoma (
30194254
)
Multiple sclerosis (
24076602
31604244
)
Pubertal anthropometrics (
23449627
)
Schizophrenia (
25056061
28991256
29483656
)
Tonsillectomy (
27182965
28928442
)
Waist circumference (
28552196
)
Weight (
28552196
)
Interacting Genes
58 interacting genes:
ASB6
BANP
BYSL
C1QTNF4
CRLF3
DEF6
DNMT1
DRC4
FLAD1
FNDC3B
FXR2
H3C1
HIF1A
HSF2BP
IL16
KANK2
KDM1A
LIG1
LMO4
LRRK2
LSM4
LZTR1
MAPK3
MAPK9
MFAP1
MORF4L1
MORF4L2
NGB
NRF1
NTAQ1
OAZ3
PDE6G
PHC2
PHF21A
PIK3R3
PLEKHF1
PLEKHF2
PLOD3
POLR2L
PPP2CA
PRKAA1
PRKAA2
RHOBTB3
SFMBT2
SNRPB
SOX2
SP100
SPANXN2
SUFU
SUMO1P1
TBC1D1
TCEANC
THRA
TRAF3IP3
TSTD2
TTC19
ZCWPW1
ZNF76
194 interacting genes:
AKR1C1
AMOT
ARRB1
ATP1A1
AURKA
BCL2
BCL3
BRAF
BTBD10
BTG2
BUB1
C1QBP
CALD1
CASP8
CASP9
CAV1
CCDC6
CDC23
CDC25C
CDC45
CDH1
CDKN2A
CEBPB
CPXM1
CREBBP
CREM
CRP
CTNND1
CUEDC2
CYLD
DAPK1
DCC
DCP1A
DEPTOR
DLC1
DUSP1
DUSP10
DUSP3
DUSP4
DUSP5
DUSP6
DUSP9
EGFR
ELK1
ELK4
EPOR
ESR1
ETS1
ETV1
FBXW7
FCGR2B
FKBP2
FOS
FOXP2
FRS2
GAB1
GAB2
GATA1
GATA4
GJA1
GMFB
GRK2
GTF2I
HDAC4
HDAC6
HES6
HIF1A
HMMR
HNF4A
HSF1
HSF4
HSPB8
HTRA2
ID2
IER3
INSR
IRS1
ITGAV
ITGB3
JUN
JUND
KRT8
KSR2
L3MBTL3
LAMTOR3
LCK
LIPE
LRPAP1
LRRC4
LYN
MAFG
MAGEA11
MAGED1
MAP2K1
MAP2K2
MAP2K3
MAP3K14
MAPK14
MAPK8
MAPKAPK2
MAPT
MBP
MED1
METAP2
MKNK1
MYC
MYLK
MYOG
NAB2
NCKIPSD
NGFR
NRAS
NTRK1
NTRK3
NUP153
NUP58
PAK2
PDCD1
PDE6G
PDGFRL
PEA15
PFKM
PLAT
PLCB1
PPARA
PPP1CA
PPP2CA
PRKCD
PRKCE
PRKCZ
PTPN11
PTPN5
PTPN7
PTPRE
PTPRR
PXN
RAB4A
RAF1
RALGDS
RB1
RCAN1
RET
RNF114
RPS6KA1
RPS6KA2
RPS6KA3
RPS6KA4
RPS6KB1
RPTOR
RXRA
SCAND1
SCRIB
SMAD2
SNCG
SORBS3
SOS1
SOX2
SP1
SPIB
SRC
SREBF1
SREBF2
STAR
STAT3
STAT5A
STK11
STMN1
STMN2
STUB1
SULT4A1
SYK
SYN1
SYNE2
TAL1
TAL2
TCF3
TGIF1
TH
TNFSF11
TOP2B
TP53
TPD52
TRIM15
TRIM54
TSC2
TTYH3
UBE4B
UBTF
USP21
VDR
VPS52
ZC3HC1
ZNF219
ZNF7
Entrez ID
84456
5595
HPRD ID
11222
03479
Ensembl ID
ENSG00000198945
ENSG00000102882
Uniprot IDs
Q96JM7
L7RXH5
P27361
Q9BWJ1
PDB IDs
1WJQ
1WJS
3UT1
4FL6
4L59
7RTE
7RTI
8Y76
8Y77
2ZOQ
4QTB
6GES
Enriched GO Terms of Interacting Partners
?
Protein Binding
Nucleus
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Gene Expression
Nucleoplasm
Regulation Of Macromolecule Metabolic Process
Histone H2BS36 Kinase Activity
[hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity
Nuclear Speck
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Metabolic Process
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Glycolytic Process
Positive Regulation Of Autophagy
Positive Regulation Of Metabolic Process
Positive Regulation Of Glycolytic Process
Protein Localization To Lipid Droplet
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Carbohydrate Catabolic Process
Chromatin Organization
Positive Regulation Of Catabolic Process
Regulation Of ATP Metabolic Process
Regulation Of RNA Metabolic Process
Negative Regulation Of Tubulin Deacetylation
Negative Regulation Of Hepatocyte Apoptotic Process
AMP-activated Protein Kinase Activity
Regulation Of Purine Nucleotide Metabolic Process
Chromatin Binding
TOR Signaling
Negative Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Tubulin Deacetylation
Lipid Droplet Disassembly
Negative Regulation Of TOR Signaling
Macromolecule Biosynthetic Process
Positive Regulation Of ATP Metabolic Process
Regulation Of Programmed Cell Death
Regulation Of DNA-templated Transcription
Negative Regulation Of Biosynthetic Process
Regulation Of RNA Biosynthetic Process
Macromolecule Metabolic Process
Positive Regulation Of G Protein-coupled Receptor Signaling Pathway
Regulation Of Neuroblast Proliferation
Regulation Of Primary Metabolic Process
Negative Regulation Of Metabolic Process
Phosphatidylethanolamine Biosynthetic Process
Negative Regulation Of Macromolecule Metabolic Process
DNA-templated Transcription
Cellular Response To Stress
Intracellular Signal Transduction
Regulation Of Signaling
Regulation Of Cell Communication
Regulation Of Multicellular Organismal Process
Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
Signal Transduction
Positive Regulation Of Metabolic Process
Regulation Of Developmental Process
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Macromolecule Metabolic Process
Intracellular Signaling Cassette
Regulation Of Apoptotic Process
Regulation Of Primary Metabolic Process
MAPK Cascade
Regulation Of Cell Differentiation
Regulation Of Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Programmed Cell Death
Regulation Of Macromolecule Metabolic Process
Developmental Process
Cellular Developmental Process
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of RNA Biosynthetic Process
Regulation Of Gene Expression
Negative Regulation Of Metabolic Process
Positive Regulation Of Signal Transduction
Positive Regulation Of Developmental Process
Positive Regulation Of DNA-templated Transcription
Cellular Response To Oxygen-containing Compound
Regulation Of MAPK Cascade
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Cell Differentiation
Enzyme-linked Receptor Protein Signaling Pathway
Positive Regulation Of Signaling
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Regulation Of Multicellular Organismal Development
Positive Regulation Of Multicellular Organismal Process
Positive Regulation Of Cell Communication
Negative Regulation Of Signal Transduction
Regulation Of RNA Biosynthetic Process
Protein Kinase Activity
Regulation Of RNA Metabolic Process
Response To Lipid
Negative Regulation Of Multicellular Organismal Process
Regulation Of DNA-templated Transcription
Regulation Of Cell Population Proliferation
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Tagcloud (Difference)
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Tagcloud (Intersection)
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