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L3MBTL3 and THRA
Number of citations of the paper that reports this interaction (PMID
25416956
)
0
Data Source:
BioGRID
(two hybrid)
L3MBTL3
THRA
Gene Name
l(3)mbt-like 3 (Drosophila)
thyroid hormone receptor, alpha
Image
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleus
Nucleoplasm
Cytosol
Molecular Function
Molecular_function
Steroid Receptor RNA Activator RNA Binding
Sequence-specific DNA Binding Transcription Factor Activity
Steroid Hormone Receptor Activity
Thyroid Hormone Receptor Activity
Protein Binding
Transcription Factor Binding
Zinc Ion Binding
TBP-class Protein Binding
Protein Domain Specific Binding
Chromatin DNA Binding
Protein Complex Binding
Sequence-specific DNA Binding
Transcription Regulatory Region DNA Binding
Thyroid Hormone Binding
Biological Process
Transcription, DNA-templated
Regulation Of Transcription, DNA-templated
Chromatin Modification
Macrophage Differentiation
Granulocyte Differentiation
Erythrocyte Maturation
Cartilage Condensation
Ossification
Regulation Of Thyroid Hormone Mediated Signaling Pathway
Regulation Of Transcription From RNA Polymerase II Promoter
Transcription From RNA Polymerase II Promoter
Transcription Initiation From RNA Polymerase II Promoter
Learning Or Memory
Regulation Of Heart Contraction
Female Courtship Behavior
Response To Cold
Hormone-mediated Signaling Pathway
Gene Expression
Positive Regulation Of Myotube Differentiation
Negative Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly
Erythrocyte Differentiation
Intracellular Receptor Signaling Pathway
Thyroid Gland Development
Regulation Of Myeloid Cell Apoptotic Process
Cytoplasmic Sequestering Of Transcription Factor
Steroid Hormone Mediated Signaling Pathway
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Female Receptivity
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Lipid Catabolic Process
Type I Pneumocyte Differentiation
Negative Regulation Of DNA-templated Transcription, Initiation
Pathways
Generic Transcription Pathway
Nuclear Receptor transcription pathway
Drugs
Liothyronine
Levothyroxine
Dextrothyroxine
Liotrix
3,5-Dichloro-4-[(4-Hydroxy-3-Isopropylphenoxy)Phenylacetic Acid
Diseases
GWAS
Height (
20881960
23563607
18391951
)
White blood cell count (
21738480
)
Protein-Protein Interactions
26 interactors:
ASB6
BANP
BYSL
KDM1A
LRRK2
LSM4
LZTR1
MAPK3
MAPK9
MORF4L1
MORF4L2
NGB
OAZ3
PDE6G
PHC2
PIK3R3
PLEKHF1
PLEKHF2
POLR2L
PRKAA1
PRKAA2
SNRPB
SP100
SUMO1P1
THRA
TTC19
56 interactors:
AKAP13
AMOTL2
ARID5A
BTG1
BUB3
C1D
CCND1
CDK7
CLIC1
COPS2
CREB1
CREBBP
CUL1
DAP3
ESR1
FOXJ1
FUS
GRIP1
GTF2B
HDAC2
HDAC3
ITGB3BP
L3MBTL3
MED1
MED21
MED25
MEF2A
NCOA1
NCOA6
NCOR1
NCOR2
NR0B2
NR2F1
NRIP1
NSD1
OASL
PML
POU2F1
PRKDC
PTGES3
RANBP9
RGN
RXRA
RXRB
RXRG
SEPP1
SLC16A2
SRC
SUV39H1
TBL1X
TDG
TRIM24
TRIP11
YWHAH
YWHAQ
ZBTB3
Entrez ID
84456
7067
HPRD ID
11222
07185
Ensembl ID
ENSG00000198945
ENSG00000126351
Uniprot IDs
Q96JM7
P10827
Q6FH41
PDB IDs
1WJQ
1WJS
3UT1
4FL6
4L59
1NAV
2H77
2H79
3HZF
3ILZ
3JZB
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of Autophagy
Chromatin Modification
Positive Regulation Of Cellular Metabolic Process
Negative Regulation Of Binding
RNA Metabolic Process
Regulation Of Autophagy
Chromatin Organization
Transcription, DNA-templated
Positive Regulation Of Metabolic Process
RNA Biosynthetic Process
Regulation Of Lipid Metabolic Process
Cellular Response To Stress
Activation Of MAPK Activity
Insulin Receptor Signaling Pathway
Negative Regulation Of Protein Binding
Negative Regulation Of Transport
Chromosome Organization
Gene Expression
Positive Regulation Of MAP Kinase Activity
Cellular Response To Insulin Stimulus
Regulation Of Energy Homeostasis
Regulation Of Apoptotic Process
Positive Regulation Of Glycolytic Process
Negative Regulation Of Intracellular Protein Transport
Fatty Acid Homeostasis
Positive Regulation Of Gene Expression
Cellular Response To Organonitrogen Compound
Regulation Of Cell Death
Cellular Nitrogen Compound Metabolic Process
Regulation Of Binding
Regulation Of Circadian Rhythm
Organelle Organization
Response To Organonitrogen Compound
Regulation Of Metabolic Process
Activation Of Protein Kinase Activity
Positive Regulation Of G-protein Coupled Receptor Protein Signaling Pathway
Positive Regulation Of Protein Serine/threonine Kinase Activity
Nucleobase-containing Compound Metabolic Process
Regulation Of MAP Kinase Activity
Response To Insulin
Negative Regulation Of Intracellular Transport
Histone-serine Phosphorylation
Regulation Of Signal Transduction
Peptidyl-serine Phosphorylation
Regulation Of Intracellular Signal Transduction
Cellular Response To Peptide Hormone Stimulus
Cellular Response To Hormone Stimulus
Response To Stress
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Cellular Response To Glucose Starvation
Transcription, DNA-templated
RNA Biosynthetic Process
Negative Regulation Of Gene Expression
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Nucleic Acid-templated Transcription
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Negative Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
RNA Metabolic Process
Gene Expression
Regulation Of Transcription, DNA-templated
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Positive Regulation Of Transcription, DNA-templated
Negative Regulation Of Biosynthetic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Nitrogen Compound Metabolic Process
Positive Regulation Of Gene Expression
Transcription From RNA Polymerase II Promoter
Transcription Initiation From RNA Polymerase II Promoter
Regulation Of Gene Expression
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Cellular Biosynthetic Process
Intracellular Receptor Signaling Pathway
Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Cellular Metabolic Process
DNA-templated Transcription, Initiation
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Biosynthetic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Cellular Metabolic Process
Regulation Of Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Positive Regulation Of Metabolic Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Nitrogen Compound Metabolic Process
Intracellular Steroid Hormone Receptor Signaling Pathway
Rhythmic Process
Organ Development
Multicellular Organismal Development
Regulation Of Cellular Process
Anatomical Structure Development
Developmental Process
Cellular Response To Organic Substance
Signal Transduction
Chromosome Organization
Signaling
System Development
Tagcloud
?
accounts
averages
bimodality
bxd
bxh
chr
counted
encode
ganglion
heritable
hoxb
idea
inbred
krt1
lod
mapped
neuregulin
nnc1
opposed
qtl
qtls
retina
retinal
striking
subsidiary
surprisingly
thyroxine
trait
vertebrate
Tagcloud (Difference)
?
accounts
averages
bimodality
bxd
bxh
chr
counted
encode
ganglion
heritable
hoxb
idea
inbred
krt1
lod
mapped
neuregulin
nnc1
opposed
qtl
qtls
retina
retinal
striking
subsidiary
surprisingly
thyroxine
trait
vertebrate
Tagcloud (Intersection)
?