L3MBTL3 and NGB

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		L3MBTL3	NGB
Description		L3MBTL histone methyl-lysine binding protein 3	neuroglobin
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus	Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol
	Molecular Function	Chromatin Binding Protein Binding Zinc Ion Binding Histone Binding Identical Protein Binding Metal Ion Binding Methylation-dependent Protein Binding	GDP-dissociation Inhibitor Activity Oxygen Carrier Activity Protein Binding Oxidoreductase Activity Oxygen Binding Heme Binding Metal Ion Binding Nitrite Reductase Activity
	Biological Process	Chromatin Organization Regulation Of DNA-templated Transcription Myeloid Cell Differentiation Macrophage Differentiation Granulocyte Differentiation Erythrocyte Maturation Negative Regulation Of DNA-templated Transcription Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process	Response To Hypoxia Oxygen Transport Cellular Response To Hypoxia
Pathways			Intracellular oxygen transport
Drugs
Diseases
GWAS		A body shape index ( 34021172) Alanine aminotransferase levels ( 34315874 33547301) Apolipoprotein B levels ( 32203549) Appendicular lean mass ( 33097823) Aspartate aminotransferase levels ( 34315874 33547301) Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Birth weight ( 27680694 31043758) Body mass index ( 25673413) Breast cancer ( 29058716 29059683) Breast cancer (estrogen-receptor negative) ( 29058716) C-reactive protein levels ( 30388399) Chronic kidney disease ( 31152163) Estimated glomerular filtration rate ( 31152163) Heel bone mineral density ( 30598549 28869591) Height ( 20881960 31562340 18391951 23563607 25282103 28552196 25429064) Hematocrit ( 27863252 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 34021172 25673412 28552196) Immature fraction of reticulocytes ( 32888494) Influenza A (H1N1) infection ( 26379185) LDL cholesterol levels ( 32203549) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (alkaline phosphatase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Low density lipoprotein cholesterol levels ( 32154731) Lymphocyte count ( 32888494 27863252) Mild influenza (H1N1) infection ( 26379185) Multiple sclerosis ( 31604244 27386562) Offspring birth weight ( 31043758) Red blood cell count ( 32888494) Reticulocyte count ( 32888494) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Spleen volume ( 34128465) Triglyceride levels ( 32203549 32154731) Triglyceride levels in HIV infection ( 33109212) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Weight ( 28552196) White blood cell count ( 32888494)
Interacting Genes		58 interacting genes: ASB6 BANP BYSL C1QTNF4 CRLF3 DEF6 DNMT1 DRC4 FLAD1 FNDC3B FXR2 H3C1 HIF1A HSF2BP IL16 KANK2 KDM1A LIG1 LMO4 LRRK2 LSM4 LZTR1 MAPK3 MAPK9 MFAP1 MORF4L1 MORF4L2 NGB NRF1 NTAQ1 OAZ3 PDE6G PHC2 PHF21A PIK3R3 PLEKHF1 PLEKHF2 PLOD3 POLR2L PPP2CA PRKAA1 PRKAA2 RHOBTB3 SFMBT2 SNRPB SOX2 SP100 SPANXN2 SUFU SUMO1P1 TBC1D1 TCEANC THRA TRAF3IP3 TSTD2 TTC19 ZCWPW1 ZNF76	23 interacting genes: AKT1 ATP1B2 BTBD2 C1orf94 DDIT4L FLOT1 GATAD2B GNAI1 GNAI2 GNAI3 GNAO1 IHO1 L3MBTL3 MAPK14 MEI4 NIF3L1 OTOS PTEN REL TDO2 TEPSIN VAC14 ZNF655
Entrez ID		84456	58157
HPRD ID		11222	05602
Ensembl ID		ENSG00000198945	ENSG00000165553
Uniprot IDs		Q96JM7	A0M8W9 Q9NPG2
PDB IDs		1WJQ 1WJS 3UT1 4FL6 4L59 7RTE 7RTI 8Y76 8Y77	1OJ6 4MPM 7VQG 8GRZ 8WUB
Enriched GO Terms of Interacting Partners?		Protein Binding Nucleus Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Nucleoplasm Regulation Of Macromolecule Metabolic Process Histone H2BS36 Kinase Activity [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Nuclear Speck Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Glycolytic Process Positive Regulation Of Autophagy Positive Regulation Of Metabolic Process Positive Regulation Of Glycolytic Process Protein Localization To Lipid Droplet Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Carbohydrate Catabolic Process Chromatin Organization Positive Regulation Of Catabolic Process Regulation Of ATP Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Tubulin Deacetylation Negative Regulation Of Hepatocyte Apoptotic Process AMP-activated Protein Kinase Activity Regulation Of Purine Nucleotide Metabolic Process Chromatin Binding TOR Signaling Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Tubulin Deacetylation Lipid Droplet Disassembly Negative Regulation Of TOR Signaling Macromolecule Biosynthetic Process Positive Regulation Of ATP Metabolic Process Regulation Of Programmed Cell Death Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process Regulation Of RNA Biosynthetic Process Macromolecule Metabolic Process Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Neuroblast Proliferation Regulation Of Primary Metabolic Process Negative Regulation Of Metabolic Process Phosphatidylethanolamine Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process DNA-templated Transcription Cellular Response To Stress	Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Heterotrimeric G-protein Complex Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway G Protein-coupled Serotonin Receptor Binding Adenylate Cyclase Regulator Activity Meiotic DNA Double-strand Break Formation Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity G Protein-coupled Receptor Binding Regulation Of Transport Myelin Maintenance Positive Regulation Of Myoblast Fusion Regulation Of Organ Growth Negative Regulation Of Transport Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle Process Regulation Of Myoblast Fusion G Protein-coupled Serotonin Receptor Signaling Pathway Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion Regulation Of Peptidyl-serine Phosphorylation Osteoblast Differentiation Response To Prostaglandin E Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Cholesterol Metabolic Process Cellular Response To Vascular Endothelial Growth Factor Stimulus Ciliary Basal Body Regulation Of Cholesterol Biosynthetic Process Centriolar Satellite Homologous Chromosome Pairing At Meiosis Positive Regulation Of Sodium Ion Transport GTPase Activity Positive Regulation Of D-glucose Import Regulation Of Smooth Muscle Cell Proliferation Regulation Of TRNA Methylation Positive Regulation Of Steroid Biosynthetic Process Lipopolysaccharide-mediated Signaling Pathway Neuronal-glial Interaction Involved In Hindbrain Glial-mediated Radial Cell Migration Negative Regulation Of Secretion By Cell Biotin--[biotin Carboxyl-carrier Protein] Ligase Activity Negative Regulation Of Synaptic Vesicle Clustering L-tryptophan Catabolic Process To Acetyl-CoA PAS Complex Coated Vesicle Membrane Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Insulin Secretion GTP Binding Positive Regulation Of Steroid Metabolic Process
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