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L3MBTL3 and PRKAA2
Number of citations of the paper that reports this interaction (PMID
25416956
)
0
Data Source:
BioGRID
(two hybrid)
L3MBTL3
PRKAA2
Gene Name
l(3)mbt-like 3 (Drosophila)
protein kinase, AMP-activated, alpha 2 catalytic subunit
Image
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytosol
Molecular Function
Molecular_function
Chromatin Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
AMP-activated Protein Kinase Activity
Protein Serine/threonine/tyrosine Kinase Activity
Protein Binding
ATP Binding
Histone Serine Kinase Activity
Metal Ion Binding
[hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity
[acetyl-CoA Carboxylase] Kinase Activity
Biological Process
Transcription, DNA-templated
Regulation Of Transcription, DNA-templated
Chromatin Modification
Macrophage Differentiation
Granulocyte Differentiation
Erythrocyte Maturation
Energy Reserve Metabolic Process
Transcription, DNA-templated
Regulation Of Transcription, DNA-templated
Protein Phosphorylation
Fatty Acid Biosynthetic Process
Cholesterol Biosynthetic Process
Carnitine Shuttle
Autophagy
Response To Stress
Organelle Organization
Mitochondrion Organization
Cell Cycle Arrest
Signal Transduction
Insulin Receptor Signaling Pathway
Lipid Biosynthetic Process
Positive Regulation Of Autophagy
Wnt Signaling Pathway
Cellular Response To Nutrient Levels
Negative Regulation Of TOR Signaling
Histone-serine Phosphorylation
Cellular Response To Glucose Starvation
Regulation Of Fatty Acid Biosynthetic Process
Glucose Homeostasis
Regulation Of Circadian Rhythm
Negative Regulation Of Apoptotic Process
Cellular Lipid Metabolic Process
Small Molecule Metabolic Process
Positive Regulation Of Glycolytic Process
Rhythmic Process
Fatty Acid Homeostasis
Membrane Organization
Regulation Of Energy Homeostasis
Pathways
Organelle biogenesis and maintenance
Integration of energy metabolism
Metabolism of lipids and lipoproteins
Regulation of Rheb GTPase activity by AMPK
IRS-mediated signalling
mTOR signalling
Translocation of GLUT4 to the plasma membrane
Import of palmitoyl-CoA into the mitochondrial matrix
mTOR signalling
IGF1R signaling cascade
IRS-related events triggered by IGF1R
Energy dependent regulation of mTOR by LKB1-AMPK
PKB-mediated events
PI3K Cascade
Signaling by Insulin receptor
Fatty acid, triacylglycerol, and ketone body metabolism
Insulin receptor signalling cascade
Regulation of AMPK activity via LKB1
IRS-related events
Mitochondrial biogenesis
IRS-mediated signalling
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
AMPK inhibits chREBP transcriptional activation activity
PKB-mediated events
PI3K Cascade
Drugs
Diseases
GWAS
Height (
20881960
23563607
18391951
)
Lymphocyte counts (
22286170
)
Protein-Protein Interactions
26 interactors:
ASB6
BANP
BYSL
KDM1A
LRRK2
LSM4
LZTR1
MAPK3
MAPK9
MORF4L1
MORF4L2
NGB
OAZ3
PDE6G
PHC2
PIK3R3
PLEKHF1
PLEKHF2
POLR2L
PRKAA1
PRKAA2
SNRPB
SP100
SUMO1P1
THRA
TTC19
48 interactors:
ABI2
ACACA
ACACB
AES
AIMP2
APPBP2
C19orf47
CCNB1IP1
EEF2K
EPM2A
FOS
GLI1
HMBOX1
HNF4A
HOMEZ
KCTD1
KIF24
KIFC3
KRT31
KRTAP10-3
L3MBTL3
LEP
MYOZ1
NECAB2
NONO
NOTCH2NL
NRAP
NUTM1
PBXIP1
PFKFB2
PRKAB1
PRKAB2
PRKAG1
RBPMS
RFX6
RPTOR
SNW1
STK11
TCF4
TMOD1
TRIP6
TSC22D4
UBE2I
USHBP1
VPS52
WWP1
ZBTB8A
ZNF397
Entrez ID
84456
5563
HPRD ID
11222
02735
Ensembl ID
ENSG00000198945
ENSG00000162409
Uniprot IDs
Q96JM7
P54646
PDB IDs
1WJQ
1WJS
3UT1
4FL6
4L59
2H6D
2LTU
2YZA
3AQV
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of Autophagy
Chromatin Modification
Positive Regulation Of Cellular Metabolic Process
Negative Regulation Of Binding
RNA Metabolic Process
Regulation Of Autophagy
Chromatin Organization
Transcription, DNA-templated
Positive Regulation Of Metabolic Process
RNA Biosynthetic Process
Regulation Of Lipid Metabolic Process
Cellular Response To Stress
Activation Of MAPK Activity
Insulin Receptor Signaling Pathway
Negative Regulation Of Protein Binding
Negative Regulation Of Transport
Chromosome Organization
Gene Expression
Positive Regulation Of MAP Kinase Activity
Cellular Response To Insulin Stimulus
Regulation Of Energy Homeostasis
Regulation Of Apoptotic Process
Positive Regulation Of Glycolytic Process
Negative Regulation Of Intracellular Protein Transport
Fatty Acid Homeostasis
Positive Regulation Of Gene Expression
Cellular Response To Organonitrogen Compound
Regulation Of Cell Death
Cellular Nitrogen Compound Metabolic Process
Regulation Of Binding
Regulation Of Circadian Rhythm
Organelle Organization
Response To Organonitrogen Compound
Regulation Of Metabolic Process
Activation Of Protein Kinase Activity
Positive Regulation Of G-protein Coupled Receptor Protein Signaling Pathway
Positive Regulation Of Protein Serine/threonine Kinase Activity
Nucleobase-containing Compound Metabolic Process
Regulation Of MAP Kinase Activity
Response To Insulin
Negative Regulation Of Intracellular Transport
Histone-serine Phosphorylation
Regulation Of Signal Transduction
Peptidyl-serine Phosphorylation
Regulation Of Intracellular Signal Transduction
Cellular Response To Peptide Hormone Stimulus
Cellular Response To Hormone Stimulus
Response To Stress
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Cellular Response To Glucose Starvation
Energy Reserve Metabolic Process
Biosynthetic Process
Regulation Of Metabolic Process
Transcription, DNA-templated
Cell Cycle Arrest
Negative Regulation Of Transcription, DNA-templated
RNA Biosynthetic Process
Insulin Receptor Signaling Pathway
Regulation Of Gene Expression
Negative Regulation Of Nucleic Acid-templated Transcription
Carnitine Shuttle
Negative Regulation Of RNA Biosynthetic Process
Regulation Of Transcription, DNA-templated
Generation Of Precursor Metabolites And Energy
Cellular Response To Hormone Stimulus
Regulation Of Nucleic Acid-templated Transcription
Response To Insulin
Regulation Of RNA Biosynthetic Process
Cellular Macromolecule Biosynthetic Process
Carnitine Transmembrane Transport
Energy Derivation By Oxidation Of Organic Compounds
Macromolecule Biosynthetic Process
Carnitine Transport
Regulation Of RNA Metabolic Process
Regulation Of Nitrogen Compound Metabolic Process
Negative Regulation Of Gene Expression
Gene Expression
Cellular Response To Insulin Stimulus
Negative Regulation Of Biosynthetic Process
RNA Metabolic Process
Malonyl-CoA Biosynthetic Process
Fatty Acid Biosynthetic Process
Positive Regulation Of Cellular Metabolic Process
Quaternary Ammonium Group Transport
Regulation Of Carbohydrate Metabolic Process
Positive Regulation Of Metabolic Process
Nucleobase-containing Compound Metabolic Process
Regulation Of Lipid Metabolic Process
Response To Peptide Hormone
Heterocycle Metabolic Process
Cellular Response To Peptide Hormone Stimulus
Cellular Aromatic Compound Metabolic Process
Cellular Metabolic Process
Fatty Acid Metabolic Process
Response To Peptide
Cellular Response To Peptide
Regulation Of Insulin Secretion
Glucose Homeostasis
Response To Hormone
Cellular Nitrogen Compound Metabolic Process
Tagcloud
?
amyloidogenesis
apmk
appswe
arc
biogenesis
functionality
igf1
igf2
igfbp2
igfr
impairments
insoluble
insr
intolerant
irs1
irs2
nrf1
oxphos
pampk
pgc
pgc1
plaque
precede
ps1
ps1de9
reinforce
sensors
tfam
thr172
Tagcloud (Difference)
?
amyloidogenesis
apmk
appswe
arc
biogenesis
functionality
igf1
igf2
igfbp2
igfr
impairments
insoluble
insr
intolerant
irs1
irs2
nrf1
oxphos
pampk
pgc
pgc1
plaque
precede
ps1
ps1de9
reinforce
sensors
tfam
thr172
Tagcloud (Intersection)
?