PRADC1 and VAC14

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		PRADC1	VAC14
Description		protease associated domain containing 1	VAC14 component of PIKFYVE complex
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region	Golgi Membrane Endosome Endoplasmic Reticulum Cytosol Endosome Membrane Membrane Early Endosome Membrane Late Endosome Membrane PAS Complex Presynaptic Endosome
	Molecular Function	Protein Binding	Protein Binding Signaling Receptor Activity Identical Protein Binding
	Biological Process		Phosphatidylinositol Biosynthetic Process Signal Transduction Regulation Of Postsynaptic Neurotransmitter Receptor Internalization
Pathways			Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the late endosome membrane Synthesis of PIPs at the late endosome membrane
Drugs
Diseases
GWAS			Diffuse cutaneous systemic sclerosis ( 29293537) Docetaxel-induced peripheral neuropathy in metastatic castrate-resistant prostate cancer ( 27143689) High density lipoprotein cholesterol levels ( 28548082) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Malaria ( 31844061) Pulse pressure ( 28135244)
Interacting Genes		3 interacting genes: DBH VAC14 XRN1	107 interacting genes: ABHD11 ACSS1 ACTMAP AMT APP ARID5A ASB13 ATM BCL2L1 BHLHE40 BKGD C4orf33 CASP1 CATSPERT CD209 CDRT4 CNTN2 COL8A1 CRK CRYBA1 CRYBA2 DDAH2 DNAAF19 EEF1AKMT3 EHHADH EIF2S1 EIF6 FAM50B FNDC3B GABPB2 GALT GINS3 GLIS2 GNB1 GTF3C2 HDHD3 HNF1B HNRNPLL INTS11 JMJD7 KHDC1 KRABD5 KRT82 KRTAP15-1 KRTAP19-3 KRTAP19-5 KRTAP19-7 KRTAP6-1 KRTAP6-2 KYAT1 LASP1 LINC00518 LPAL2 MBLAC1 MEOX2 METTL15 MGAT5B MPPED2 MTMR9 MVP MYOZ1 NDUFAB1 NGB NOS1 NTAQ1 OIT3 OTOS PBLD PCMTD2 PDE4DIP PELI1 PHF1 PHYKPL PIKFYVE PPP2CA PPP6C PRADC1 PRR13 PRR20A PRR20B PRR20C PRR20D PRR20E RBFOX2 RHBDL1 RHOXF2 RIPPLY1 RNASEH2C RSKR SIGLEC5 SMUG1 SNF8 SPMIP9 SPRYD7 SRPK2 TCEANC TP53BP1 TRIM55 TRIM63 UFSP1 VENTX VHLL WDR83 WRAP53 ZBTB49 ZCWPW1 ZNF34
Entrez ID		84279	55697
HPRD ID		12815	07660
Ensembl ID		ENSG00000135617	ENSG00000103043
Uniprot IDs		Q9BSG0	Q08AM6
PDB IDs			7K1Y
Enriched GO Terms of Interacting Partners?		Dopamine Beta-monooxygenase Activity Octopamine Biosynthetic Process Chromaffin Granule Lumen Homoiothermy Cellular Response To Puromycin Cellular Response To Cycloheximide PAS Complex Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Ascorbate As One Donor, And Incorporation Of One Atom Of Oxygen 5'-3' RNA Exonuclease Activity Response To Cycloheximide Catecholamine Catabolic Process Chromaffin Granule Membrane Norepinephrine Biosynthetic Process Dopamine Catabolic Process G-quadruplex RNA Binding G-quadruplex DNA Binding Presynaptic Endosome Behavioral Response To Ethanol 5'-3' Exonuclease Activity Nuclear MRNA Surveillance Maternal Behavior L-ascorbic Acid Binding Response To Pain Catecholamine Biosynthetic Process Norepinephrine Metabolic Process Parental Behavior RRNA Catabolic Process Histone MRNA Catabolic Process Negative Regulation Of Telomere Maintenance Via Telomerase Telomerase RNA Binding Histone MRNA Metabolic Process Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Vasoconstriction Amine Biosynthetic Process Temperature Homeostasis Response To Amphetamine Positive Regulation Of Vasoconstriction Biogenic Amine Biosynthetic Process Reproductive Behavior Regulation Of Vascular Endothelial Cell Proliferation Dopamine Metabolic Process Nuclear RNA Surveillance Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Fear Response Catecholamine Metabolic Process Blood Vessel Remodeling Regulation Of Telomere Maintenance Via Telomerase RNA Surveillance	Protein Binding Intermediate Filament
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