PRADC1 and DBH

Number of citations of the paper that reports this interaction (PubMedID 15498570)
0

Data Source:
HPRD (in vitro)

		PRADC1	DBH
Description		protease associated domain containing 1	dopamine beta-hydroxylase
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Membrane Transport Vesicle Membrane Secretory Granule Membrane Cytoplasmic Vesicle Centriolar Satellite Chromaffin Granule Lumen Secretory Granule Lumen Chromaffin Granule Membrane Synapse
	Molecular Function	Protein Binding	Catalytic Activity Monooxygenase Activity Dopamine Beta-monooxygenase Activity Copper Ion Binding Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Ascorbate As One Donor, And Incorporation Of One Atom Of Oxygen L-ascorbic Acid Binding Metal Ion Binding
	Biological Process		Blood Vessel Remodeling Response To Amphetamine Leukocyte Mediated Immunity Octopamine Biosynthetic Process Chemical Synaptic Transmission Memory Locomotory Behavior Associative Learning Visual Learning Homoiothermy Vasoconstriction Dopamine Catabolic Process Norepinephrine Biosynthetic Process Catecholamine Biosynthetic Process Glucose Homeostasis Fear Response Maternal Behavior Positive Regulation Of Vasoconstriction Behavioral Response To Ethanol Response To Pain Leukocyte Migration Positive Regulation Of Cold-induced Thermogenesis Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Regulation Of Vascular Endothelial Cell Proliferation Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways			Catecholamine biosynthesis
Drugs			Ascorbic acid Disulfiram Dopamine
Diseases			Dopamine beta-hydroxylase deficiency; Norepinephrine deficiency; Noradrenaline deficiency
GWAS			Diastolic blood pressure ( 27618452 28739976) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Mean arterial pressure ( 27618448) Nicotine dependence ( 33144568 28972577) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Smoking behavior ( 20418890) Smoking behaviour (cigarette pack-years) ( 30679032) Smoking behaviour (cigarettes smoked per day) ( 30679032) Smoking cessation ( 30617275 33082346) Smoking status (current vs mixed) ( 33082346) Smoking status (current vs never) ( 33082346) Squamous cell lung carcinoma ( 28604730) Systolic blood pressure ( 27618452 30578418)
Interacting Genes		3 interacting genes: DBH VAC14 XRN1	5 interacting genes: CYSRT1 NBPF19 NOTCH2NLA PRADC1 SNCA
Entrez ID		84279	1621
HPRD ID		12815	01963
Ensembl ID		ENSG00000135617	ENSG00000123454
Uniprot IDs		Q9BSG0	P09172
PDB IDs			4ZEL
Enriched GO Terms of Interacting Partners?		Dopamine Beta-monooxygenase Activity Octopamine Biosynthetic Process Chromaffin Granule Lumen Homoiothermy Cellular Response To Puromycin Cellular Response To Cycloheximide PAS Complex Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Ascorbate As One Donor, And Incorporation Of One Atom Of Oxygen 5'-3' RNA Exonuclease Activity Response To Cycloheximide Catecholamine Catabolic Process Chromaffin Granule Membrane Norepinephrine Biosynthetic Process Dopamine Catabolic Process G-quadruplex RNA Binding G-quadruplex DNA Binding Presynaptic Endosome Behavioral Response To Ethanol 5'-3' Exonuclease Activity Nuclear MRNA Surveillance Maternal Behavior L-ascorbic Acid Binding Response To Pain Catecholamine Biosynthetic Process Norepinephrine Metabolic Process Parental Behavior RRNA Catabolic Process Histone MRNA Catabolic Process Negative Regulation Of Telomere Maintenance Via Telomerase Telomerase RNA Binding Histone MRNA Metabolic Process Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Vasoconstriction Amine Biosynthetic Process Temperature Homeostasis Response To Amphetamine Positive Regulation Of Vasoconstriction Biogenic Amine Biosynthetic Process Reproductive Behavior Regulation Of Vascular Endothelial Cell Proliferation Dopamine Metabolic Process Nuclear RNA Surveillance Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Fear Response Catecholamine Metabolic Process Blood Vessel Remodeling Regulation Of Telomere Maintenance Via Telomerase RNA Surveillance	Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Negative Regulation Of Chaperone-mediated Autophagy Negative Regulation Of Dopamine Metabolic Process Regulation Of Serotonin Uptake Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Negative Regulation Of Catecholamine Metabolic Process Dopamine Uptake Involved In Synaptic Transmission Mitochondrial ATP Synthesis Coupled Electron Transport Cuprous Ion Binding Regulation Of Chaperone-mediated Autophagy Response To Iron(II) Ion Dopamine Biosynthetic Process Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Cellular Respiration Negative Regulation Of Oxidative Phosphorylation Regulation Of Acyl-CoA Biosynthetic Process Supramolecular Fiber Catecholamine Uptake Dopamine Uptake Positive Regulation Of Inositol Phosphate Biosynthetic Process SNARE Complex Assembly Cellular Response To Epinephrine Stimulus Regulation Of SNARE Complex Assembly Negative Regulation Of Microtubule Polymerization Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway ATP Synthesis Coupled Electron Transport Positive Regulation Of Receptor Recycling Synaptic Transmission, Dopaminergic Response To Epinephrine Positive Regulation Of Neurotransmitter Secretion Regulation Of Hydrogen Peroxide Metabolic Process Platelet Alpha Granule Membrane Dynein Complex Binding Synaptic Vesicle Priming Dopamine Transport Inclusion Body Neurotransmitter Reuptake Catecholamine Biosynthetic Process Response To Magnesium Ion Behavioral Response To Cocaine Phospholipase Binding
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